Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres

Journal of Physiology

Volumn 588, Issue 3, 2010, Pages 511-525

  Hamdi, M M ^a   Mutungi, G ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANDROSTANOLONE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN LIGHT CHAIN; SEX HORMONE; TESTOSTERONE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANDROGEN RECEPTOR ANTAGONIST; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FAST MUSCLE FIBER; FEMALE; HORMONE ACTION; MALE; MAMMAL; MOUSE; MUSCLE FORCE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE TETANIC CONTRACTION; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SLOW MUSCLE FIBER; ADULT; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; ISOMETRICS; PROTEIN FUNCTION;

ANIMALS; DIHYDROTESTOSTERONE; FEMALE; ISOMETRIC CONTRACTION; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUSCLE CONTRACTION; MUSCLE FIBERS, FAST-TWITCH; MUSCLE FIBERS, SKELETAL; MUSCLE FIBERS, SLOW-TWITCH; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 75649099769     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.182162     Document Type: Article

References (47)

1. Adelstein RS. Regulation of contractile proteins by phosphorylation. J Clin Invest 1983, 72:1863-1866.
2. Basaria S, Wahlstrom JT, Dobs AS. Anabolic-androgenic steroid therapy in the treatment of chronic diseases. J Clin Endocrinol Metab 2001, 86:5108-5117.
3. Beato M. Gene regulation by steroid hormones. Cell 1989, 56:335-344.
4. Beato M, Chávez S, Truss M. Transcriptional regulation by steroid hormones. Steroids 1996, 61:240-251.
5. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 2001, 281:E1172-E1181.
6. Blanco CE, Popper P, Micevych P. Anabolic-androgenic steroid induced alterations in choline acetyltransferase messenger RNA levels of spinal cord motoneurons in the male rat. Neuroscience 1997, 78:873-882.
7. Bresnick AR. Molecular mechanisms of nonmuscle myosin-II regulation. Curr Opin Cell Biol 1999, 11:26-33.
8. Bruchovsky N, Wilson JD. The conversion of testosterone to 5α-androstan-17β-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 1968, 243:2012-2021.
9. Chen Y, Zajac J, MacLean HE. Androgen regulation of satellite cell function. J Endocrinol 2005, 186:21-31.
10. Cheng J, Zhang C, Shapiro DJ. A functional serine 118 phosphorylation site in estrogen receptor-α is required for down-regulation of gene expression by 17β estradiol and 4-hydroxytamoxifen. Endocrinology 2007, 148:4634-4641.
11. Close R, Hoh JFY. After-effects of repetitive stimulation on isometric twitch contraction of rat fast skeletal muscle. J Physiol 1968, 197:461-477.
12. Close R, Hoh JFY. Post-tetanic potentiation of twitch contractions of cross-innervated rat fast and slow muscles. Nature 1969, 221:179-181.
13. Drummond GB. Reporting ethical matters in The Journal of Physiology: standards and advice. J Physiol 2009, 587:713-719.
14. Egginton S. Effects of an anabolic hormone on striated muscle growth and performance. Pflugers Arch 1987, 410:349-355.
15. Estrada M, Espinosa A, Muller M, Jaimovich E. Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells. Endocrinology 2003, 144:3586-3597.
16. Estrada M, Liberona JL, Miranda M, Jaimovich E. Aldosterone- and testosterone-mediated intracellular calcium response in skeletal muscle cell cultures. Am J Physiol Endocrinol Metab 2000, 279:E132-E139.
17. Evans NA. Current concepts in anabolic-androgenic steroids. Am J Sports Med 2004, 32:534-542.
18. Exner GU, Staudte HW, Pette D. Isometric training of rats - effects upon fast and slow muscle and modification by an anabolic hormone (nandrolone decanoate). I. Female rats. Pflugers Arch 1973a, 345:1-14.
19. Exner GU, Staudte HW, Pette D. Isometric training of rats - effects upon fast and slow muscle and modification by an anabolic hormone (nandrolone decanoate). II. Male rats. Pflugers Arch 1973b, 345:15-22.
20. Falkenstein E, Tillmann H-C, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones - A focus on rapid, nongenomic effects. Pharmacol Rev 2000, 52:513-556.
21. Florini JR. Effects of testosterone on qualitative pattern of protein synthesis in skeletal muscle. Biochemistry 1970, 9:909-912.
22. Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol 2002, 20:3001-3015.
23. Gordon AM, Homsher E, Regnier M. Regulation of contraction in striated muscle. Physiol Rev 2000, 80:853-924.
24. Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev 2002a, 23:175-200.
25. Heinlein CA, Chang C. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 2002b, 16:2181-2187.
26. Houston ME, Green HJ, Stull JT. Myosin light chain phosphorylation and isometric twitch potentiation in intact human muscle. Pflugers Arch 1985, 403:348-352.
27. Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C δ-dependent pathway. J Biol Chem 2004, 279:14551-14560.
28. Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA. Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997, 137:481-492.
29. Klug GA, Botterman BR, Stull JT. The effect of low frequency stimulation on myosin light chain phosphorylation in skeletal muscle. J Biol Chem 1982, 257:4688-4690.
30. Losel RM, Falkenstein E, Feuring M, Schultz A, Tillmann H-C, Rossol-Haseroth K, Wehling M. Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 2003, 83:965-1016.
31. Manning DR, Stull JT. Myosin light chain phosphorylation and phosphorylase-A activity in rat extensor digitorum longus muscle. Biochem Biophys Res Commun 1979, 90:164-170.
32. Marshall MS. Ras target proteins in eukaryotic cells. FASEB J 1995, 9:1311-1318.
33. Metzger JM, Greaser ML, Moss R. Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibres. Implications for twitch potentiation in intact muscle. J Gen Physiol 1989, 93:855-883.
34. Moore RL, Stull JT. Myosin light chain phosphorylation in fast and slow skeletal-muscles in situ. Am J Physiol Cell Physiol 1984, 247:C462-C471.
35. Mutungi G. The expression of NFATc1 in adult rat skeletal muscle fibres. Exp Physiol 2008, 93:399-406.
36. Mutungi G, Ranatunga KW. Sarcomere length changes during end-held (isometric) contractions in intact mammalian (rat) fast and slow muscle fibres. J Muscle Res Cell Motil 2000, 21:565-575.
37. Nguyen TH, Lee GS, Ji YK, Choi KC, Lee CK, Jeung EB. A calcium binding protein, calbindin-D9k, is mainly regulated by estrogen in the pituitary gland of rats during estrous cycle. Mol Brain Res 2005, 141:166-173.
38. Pardridge WM. Serum bioavailability of sex steroid hormones. Clin Endocrinol Metab 1986, 15:259-278.
39. Rahman F, Christian HC. Non-classical actions of testosterone: an update. Trends Endocrinol Metab 2007, 18:371-378.
40. Saartok T, Dahlberg E, Gustafsson JA. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology 1984, 114:2100-2106.
41. Salmons S. Myotrophic effects of an anabolic steroid in rabbit limb muscles. Muscle Nerve 1992, 15:806-812.
42. Simental JA, Sar M, Lane MV, French FS, Wilson EM. Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 1991, 266:510-518.
43. Simoncini T, Genazzani AR. Non-genomic actions of sex steroid hormones. Eur J Endocrinol 2003, 148:281-292.
44. Sweeny HL, Bowman BF, Stull JT. Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. Am J Physiol Cell Physiol 1993, 264:C1085-C1095.
45. Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW. Tissue distribution and ontogeny of steroid 5-α-reductase isozyme expression. J Clin Invest 1993, 92:903-910.
46. van der Vies J. Model studies with long-acting hormonal preparations. Acta Endocrinol 1970, 64:656-669.
47. Wilson CM, McPhaul MJ. A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol Cell Endocrinol 1996, 120:51-57.