Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallel in vitro bioassays

Biotechnology Journal

Volumn 5, Issue 1, 2010, Pages 62-74

  Zimmermann, Hanne ^a   Gerhard, Daniel ^b   Dingermann, Theo ^c   Hothorn, Ludwig A ^b  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Assay validation; Linear parallel line assay; Mixed model approach; Non linear parallel line assay; Variance component analysis

Indexed keywords

LINEAR PARALLEL-LINE ASSAY; MIXED MODEL APPROACH; MIXED MODELS; NON-LINEAR; VARIANCE COMPONENT ANALYSIS;

FUNCTION EVALUATION;

ASSAYS;

ARTICLE; BIOASSAY; CELL ASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VALIDATION PROCESS; VARIANCE;

BIOLOGICAL ASSAY; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; IMMUNOASSAY; LINEAR MODELS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NONLINEAR DYNAMICS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 75649098212     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200900146     Document Type: Article

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