Abnormal blood pressure response to exercise occurs more frequently in hypertrophic cardiomyopathy patients with the R92W troponin T mutation than in those with myosin mutations

Heart Rhythm

Volumn 6, Issue 11 SUPPL., 2009, Pages

  Heradien, Marshall ^a   Revera, Miriam ^b   Van Der Merwe, Lize ^c   Goosen, Althea ^a   Corfield, Valerie A ^a   Brink, Paul A ^c   Mayosi, Bongani M ^d   Moolman Smook, Johanna C ^a,d  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Abnormal blood pressure response; Beta myosin; Genetic mutation; Hypertrophic cardiomyopathy; Survival; Troponin T

Indexed keywords

CARDIAC MYOSIN; TNNT2 PROTEIN, HUMAN; TROPONIN T;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD PRESSURE; ECHOCARDIOGRAPHY; EXERCISE TEST; FEMALE; GENETICS; HEART RATE; HETEROZYGOTE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MALE; MIDDLE AGED; MUTATION; PATHOPHYSIOLOGY; RISK FACTOR; SUDDEN DEATH;

ADOLESCENT; ADULT; AGED; BLOOD PRESSURE; CARDIAC MYOSINS; CARDIOMYOPATHY, HYPERTROPHIC; DEATH, SUDDEN, CARDIAC; ECHOCARDIOGRAPHY; EXERCISE TEST; FEMALE; HEART RATE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; RISK FACTORS; TROPONIN T; YOUNG ADULT;

EID: 75549089152     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.07.020     Document Type: Conference Paper

References (33)

1. Maron BJ, Gardin JM, Flack JM, et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 1995;92:785-789.
2. Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet 2004;363:1881-1891.
3. Watkins H, McKenna WJ, Thierfelder L, et al. Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. N Engl J Med 1995;332:1058-1064.
4. Varnava AM, Elliott PM, Baboonian C, et al. Hypertrophic cardiomyopathy: histopathological features of sudden death in cardiac troponin T disease. Circulation 2001;104:1380-1384.
5. Tardiff JC, Hewett TE, Palmer BM, et al. Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest 1999;104:469-481.
6. Ertz-Berger BR, He H, Dowell C, et al. Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proc Natl Acad Sci U S A 2005;102:18219-18224.
7. Moolman JC, Corfield VA, Posen B, et al. Sudden death due to troponin T mutations. J Am Coll Cardiol 1997;29:549-555.
8. Olivotto I, Maron BJ, Montereggi A, et al. Prognostic value of systemic blood pressure response during exercise in a community-based patient population with hypertrophic cardiomyopathy. J Am Coll Cardiol 1999;33:2044-2051.
9. Frenneaux MP, Counihan PJ, Caforio AL, et al. Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy. Circulation 1990;82: 1995-2002.
10. Kawasaki T, Azuma A, Kuribayashi T, et al. Vagal enhancement due to subendocardial ischemia as a cause of abnormal blood pressure response in hypertrophic cardiomyopathy. Int J Cardiol 2008;129:59-64.
11. Sadoul N, Prasad K, Elliott PM, et al. Prospective prognostic assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy. Circulation 1997;96:2987-2991.
12. Moolman-Smook JC, De Lange WJ, Bruwer EC, et al. The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: a unique profile of both independent and founder events. Am J Hum Genet 1999;65:1308-1320.
13. Revera M, Van Der ML, Heradien M, et al. Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy. Cardiovasc Res 2008;77:687-694.
14. Bruce RA, McDonough JR. Stress testing in screening for cardiovascular disease. Bull N Y Acad Med 1969;45:1288-1305.
15. Nanas S, Nastasiou-Nana M, Dimopoulos S, et al. Early heart rate recovery after exercise predicts mortality in patients with chronic heart failure. Int J Cardiol 2006;110:393-400.
16. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367.
17. Maron MS, Olivotto I, Betocchi S, et al. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003;348:295-303.
18. Sobel E, Sengul H, Weeks DE. Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum Hered 2001;52:121-131.
19. Pilia G, Chen WM, Scuteri A, et al. Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2006;2:e132.
20. Sakata K, Ino H, Scuteri N, et al. Exercise-induced systolic dysfunction in patients with non-obstructive hypertrophic cardiomyopathy and mutations in the cardiac troponin genes. Heart 2008;94:1282-1287.
21. Counihan PJ, Frenneaux MP, Webb DJ, et al. Abnormal vascular responses to supine exercise in hypertrophic cardiomyopathy. Circulation 1991;84:686-696.
22. Ciampi Q, Betocchi S, Lombardi R, et al. Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy. J Am Coll Cardiol 2002;40:278-284.
23. Ciampi Q, Betocchi S, Losi MA, et al. Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy. J Nucl Cardiol 2007;14:869-875.
24. Lim PO, Morris-Thurgood JA, Frenneaux MP. Vascular mechanisms of sudden death in hypertrophic cardiomyopathy, including blood pressure responses to exercise. Cardiol Rev 2002;10:15-23.
25. Omodani H, Kinugawa T, Ogino K, et al. Augmented exercise plasma noradrenaline with impaired chronotropic responsiveness in patients with hypertrophic cardiomyopathy. Clin Exp Pharmacol Physiol 1998;25: 1018-1023.
26. Carl I, Ong H, Donnelly R, et al. Exercise in hypertrophic cardiomyopathy is associated with sympatho-adrenal imbalance. Int J Cardiol 2007;116:124-125.
27. Knollmann BC, Blatt SA, Horton K, et al. Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy. J Biol Chem 2001;276:10039- 10048.
28. Okeie K, Shimizu M, Yoshio H, et al. Left ventricular systolic dysfunction during exercise and dobutamine stress in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2000;36:856-863.
29. Kuo TB, Lin T, Yang CC, et al. Effect of aging on gender differences in neural control of heart rate. Am J Physiol 1999;277:H2233-H2239.
30. Watson G, Mechling E, Ewy GA. Clinical significance of early vs late hypotensive blood pressure response to treadmill exercise. Arch Intern Med 1992; 152:1005-1008.
31. Comess KA, Fenster PE. Clinical implications of the blood pressure response to exercise. Cardiology 1981;68:233-244.
32. Irace C, Scavelli F, Carallo C, et al. Body mass index, metabolic syndrome and carotid atherosclerosis. Coron Artery Dis 2009;20:94-99.
33. Zoghbi WA, Enriquez-Sarano M, Foster E, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr 2003;16:777-802.