Prevalence of factor V Leiden mutation in patients with thrombosis in Tunisia

Eastern Mediterranean Health Journal

Volumn 15, Issue 6, 2009, Pages 1483-1488

  Ajem, A ^a   Slama, A ^b   Slama, F B H ^a   Mehjoub, T ^b  

^a UNIVERSITY OF SOUSSE   (Tunisia)

^b FARHAT HACHED HOSPITAL   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ADOLESCENT; ADULT; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MUTATION; POLYMERASE CHAIN REACTION; PREVALENCE; TUNISIA; VEIN THROMBOSIS;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FACTOR V; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; INFANT; INPATIENTS; MIDDLE AGED; PEDIGREE; POLYMERASE CHAIN REACTION; PREVALENCE; RISK FACTORS; THROMBOSIS; TUNISIA;

EID: 75449115153     PISSN: 10203397     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet, 1999, 353:1167-73.
2. Kalafatis M et al. Characterization of the molecular defect in factor V R506Q. Journal of biological chemistry, 1995, 270:4053-7.
3. Orban T, Kalafatis M, Gogonea V. Completed three-dimensional model of human coagulation factor Va. Molecular dynamics simulations and structural analysis. Biochemistry, 2005, 44:13082-90.
4. Taymaz H et al. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thrombosis research, 2007, 119:55-62.
5. Irani-Hakime N et al. Factor V R506Q mutation-Leiden: an independent risk factor for venous thrombosis but not coronary artery disease. Journal of thrombosis and thrombolysis, 2001, 11:111-6.
6. Aleksic M et al. Comparison of the prevalence of APC-resistance in vascular patients and in a normal population cohort in Western Germany. European journal of vascular and endovascular surgery, 2005, 30:160-3.
7. Alonso A et al. Acquired and inherited thrombophilia in women with unexplained fetal losses. American journal of obstetrics and gynaecology, 2002, 187:1337-42.
8. Onderoglu L et al. High frequency of thrombophilic disorders in women with recurrent fetal miscarriage. Clinical and experimental obstetrics & gynecology, 2006, 33:50-4.
9. Lucotte G, Mercier G. Population genetics of factor V Leiden in Europe. Blood cells, molecules and diseases, 2001, 27:362-7.
10. Bauduer F, Lacombe D. Factor V Leiden, prothrombin 20210, methylenetetrahydrofolate reductase 677T, and population genetics. Molecular genetics and metabolism, 2005, 86:91-9.
11. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic acids research, 1988, 16:1215.
12. Hezard N et al. Factor V Leiden: detection in whole blood by ASA PCR using an additional mismatch in antepenultimate position. Thrombosis research, 1997, 88:59-66.
13. Reitsma PH et al. The putative factor IX gene promoter in hemophilia B Leyden. Blood, 1988, 72:1074-6.
14. Cushman M et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. American journal of medicine, 2004, 117:516-22.
15. Colaizzo D et al. Gain-of-function gene mutations and venous thromboembolism: distinct roles in different clinical settings. Journal of medical genetics, 2007, 44:412-6.
16. Juul K et al. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Annals of internal medicine, 2004, 140:330-7.
17. Pathare A et al. Hereditary thrombophilia in ethnic Omani patients. American journal of haematology, 2006, 81:101-6.
18. Angchaisuksiri P et al. Prevalence of the G1691A mutation in the factor V gene (factor V Leiden) and the G20210A prothrombin gene mutation in the Thai population. American journal of haematology, 2000, 65:119-22.
19. Bouaziz L et al. Allelic frequency of the factor V Leiden mutation and of the prothrombin gene 20210A mutation in healthy Tunisian population. Thrombosis and haemostasis, 2004, 91:824-5.
20. Almawi WY et al. Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs. Journal of thrombosis and thrombolysis, 2005, 20:163-8.
21. Caprini JA et al. Laboratory markers in the diagnosis of venous thromboembolism. Circulation, 2004, 109:14-8.
22. Gallus AS. Management options for thrombophilias. Seminars in thrombosis and hemostasis, 2005, 31:118-26.
23. Zee RY et al. Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis. Journal of thrombosis and haemostasis, 2006, 4:341-8.
24. Page C et al. Arterial thrombosis associated with heterozygous factor V Leiden disorder, hyperhomocysteinemia, and peripheral arterial disease: importance of synergistic factors. Journal of vascular surgery, 2005, 42:1014-8.