Deferoxamine, the newly developed iron chelator LK-614 and N-α-acetyl-histidine in myocardial protection

Interactive Cardiovascular and Thoracic Surgery

Volumn 10, Issue 2, 2010, Pages 181-184

  Koch, Achim ^a   Loganathan, Sivakkanan ^a   Radovits, Tamas ^a   Sack, Falk Udo ^a   Karck, Matthias ^a   Szabó, Gabor B ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cold ischemic injury; Iron chelators; N acetyl L histidine; Rat heart transplantation

Indexed keywords

ARGININE; DEFEROXAMINE; HTK SOLUTION; IRON CHELATING AGENT; LK 614; N ACETYLHISTIDINE; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANASTOMOSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CAVA VEIN; COLD INJURY; CONTROLLED STUDY; DONOR; HEART; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HEART MUSCLE RELAXATION; HEART PROTECTION; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECIPIENT; REPERFUSION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; COLD ISCHEMIA; DEFEROXAMINE; GLUCOSE; HEART TRANSPLANTATION; HISTIDINE; HYDROXAMIC ACIDS; IRON CHELATING AGENTS; MALE; MANNITOL; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; POTASSIUM CHLORIDE; PROCAINE; RATS; RATS, INBRED LEW; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 75449113687     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2009.213280     Document Type: Article

References (15)

1. Oosterlee A, Rahmel A. Annual report - Eurotransplant International Foundation. Leiden/NL 2007:33-35.
2. Hachida M, Ookado A, Nonoyama M, Koyanagi H. Effect of HTK solution for myocardial preservation. J Cardiovasc Surg (Torino) 1996;37:269-274.
3. Perrault LP, Carrier M. The central role of the endothelium in graft coronary vasculopathy and heart transplantation. Can J Cardiol 2005; 21:1077-1083.
4. [4 Vanhoutte PM. Endothelial dysfunction and arterosclerosis. Eur Heart J 1997;18(Suppl E):E19-E29.
5. Podesser BK, Hallström S. Nitric oxide homeostasis as a target for drug additives to cardioplegia. Br J Pharmacol 2007;151:930-940.
6. Graf E, Mahoney JR, Bryant RG, Eaton JW. Iron-catalysed hydroxyl radical formation. Stringent requirement for free iron coordination site. J Biol Chem 1984;259:3620-3624.
7. Rauen U, de Groot H. New insights into the cellular and molecular mechanisms of cold storage injury. J Invest Med 2004;52:299-309.
8. Rauen U, Klempt S, de Groot H. Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators. Cell Mol Life Sci 2007;64:192-205.
9. Szabó G, Bährle S, Stumpf N, Sonnenberg K, Szabó EE, Pacher P, Csont T, Schulz R, Dengler TJ, Liaudet L, Jagtap PG, Southan GJ, Vahl CF, Hagl S, Szabó C. Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res 2002;90:100-106.
10. Yang Q, Zhang RZ, Yim APC, He GW. Histidine-tryptophan-ketoglutarate solution maximally preserves endothelium-derived hyperpolarizing factor-mediated function during heart preservation: comparison with University of Wisconsin solution. J Heart Lung Transplant 2004;23:352-359.
11. Schröder C, Heintz A, Pexa A, Rauen U, Deussen A. Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additives. Eur J Cardiothorac Surg 2007;31:821-826.
12. Salahudeen AK. Cold ischemic injury of transplanted kidneys: new insights from experimental studies. Am J Physiol Renal Physiol 2004; 287:F181-F187.
13. Rauen U, Kerkweg U, de Groot H. Iron-dependent vs. iron-independent cold induced injury to cultured rat hepatocytes: a comparative study in physiological media and organ preservation solutions. Cryobiology 2007;54:77-86.
14. Radovits T, Lin L, Zotkina J, Koch A, Rauen U, Köhler G, Karck M, Szabó GB. Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-α-acetyk- Lhistidine. J Heart Lung Transplant 2008;27:208-216.
15. Szabó G, Bährle S, Bátkai S, Stumpf N, Dengler TJ, Zimmermann R, Vahl CF, Hagl S. L-Arginine: effect on reperfusion injury after heart transplantation. World J Surg 1998;22:791-798.