Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction

Cytokine

Volumn 49, Issue 3, 2010, Pages 264-268

  Matsumoto, Mika ^a   Tsujino, Takeshi ^a   Lee Kawabata, Masaaki ^a   Naito, Yoshiro ^a   Sakoda, Tsuyoshi ^a   Ohyanagi, Mitsumasa ^a   Masuyama, Tohru ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Acute decompensated heart failure; Highly sensitive C reactive protein; Interleukin 6

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTERLEUKIN 18; INTERLEUKIN 6; LOOP DIURETIC AGENT; SPIRONOLACTONE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEART FAILURE; ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SENSITIVITY AND SPECIFICITY; SYSTOLIC DYSFUNCTION; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; CYTOKINES; FEMALE; HEART FAILURE; HUMANS; INTERLEUKIN-18; INTERLEUKIN-6; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 75449106953     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2009.11.006     Document Type: Article

References (21)

1. Torre-Amione G. Immune activation in chronic heart failure. Am J Cardiol 95 (2005) 3C-8C
2. Torre-Amione G., Kapadia S., Benedict C., Oral H., Young J.B., and Mann D.L. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 27 (1996) 1201-1206
3. Levine B., Kalman J., Mayer L., Fillit H.M., and Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323 (1990) 236-241
4. Naito Y., Tsujino T., Fujioka Y., Ohyanagi M., Okamura H., and Iwasaki T. Increased circulating interleukin-18 in patients with congestive heart failure. Heart 88 (2002) 296-297
5. Yu X., Kennedy R.H., and Liu S. JJAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. J Biol Chem 278 (2003) 16304-16309
6. Fischer P., and Hilfiker-Kleiner D. Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis. Basic Res Cardiol 102 (2007) 279-297
7. Alonso-Martínez J.L., Llorente-Diez B., Echegaray-Agara M., Olaz-Preciado F., Urbieta-Echezarreta M., and González-Arencibia C. C-reactive protein as a predictor of improvement and readmission in heart failure. Eur J Heart Fail 4 (2002) 331-336
8. Finkel M.S., Oddis C.V., Jacob T.D., Watkins S.C., Hattler B.G., and Simmons R.L. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257 (1992) 387-389
9. i and cell contraction in cultured chick ventricular myocytes. Circ Res 75 (1994) 285-295
10. Ikeda U., Maeda Y., Yamamoto K., and Shimada K. C-reactive protein augments inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes. Cardiovasc Res 56 (2002) 86-92
11. Tsutamoto T., Hisanaga T., Wada A., Maeda K., Ohnishi M., Fukai D., et al. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31 (1998) 391-398
12. Munger M.A., Johnson B., Amber I.J., Callahan K.S., and Gilbert E.M. Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 77 (1996) 723-727
13. Zhang Y., Lin J.X., and Vilcek J. Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. J Biol Chem 263 (1988) 6177-6182
14. Ohkawa F., Ikeda U., Kanbe T., Kawasaki K., and Shimada K. Effects of inflammatory cytokines on vascular tone. Cardiovasc Res 30 (1995) 711-715
15. Nozaki N., Yamaguchi S., Shirakabe M., Nakamura H., and Tomoike H. Soluble tumor necrosis factor receptors are elevated in relation to severity of congestive heart failure. Jpn Circ J 61 (1997) 657-664
16. Gullestad L., Aukrust P., Ueland T., Espevik T., Yee G., Vagelos R., et al. Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. J Am Coll Cardiol 34 (1999) 2061-2067
17. Ancey C., Menet E., Corbi P., Fredj S., Garcia M., Rücker-Martin C., et al. Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation. Cardiovasc Res 59 (2003) 78-85
18. Matsushita K., Iwanaga S., Oda T., Kimura K., Shimada M., Sano M., et al. Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Lab Invest 85 (2005) 1210-1223
19. Hamid T., Gu Y., Ortines R.V., Bhattacharya C., Wang G., Xuan Y.T., et al. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation 119 (2009) 1386-1397
20. Chandrasekar B., Vemula K., Surabhi R.M., Li-Weber M., Owen-Schaub L.B., Jensen L.E., et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem 279 (2004) 20221-20233
21. Vasan R.S., and Levy D. Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation 101 (2000) 2118-2121