-
1
-
-
31944452253
-
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
-
King BM. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav 2006, 87:221-244.
-
(2006)
Physiol Behav
, vol.87
, pp. 221-244
-
-
King, B.M.1
-
2
-
-
0028296222
-
Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia
-
Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 1994, 93:1677-1682.
-
(1994)
J Clin Invest
, vol.93
, pp. 1677-1682
-
-
Borg, W.P.1
During, M.J.2
Sherwin, R.S.3
Borg, M.A.4
Brines, M.L.5
Shulman, G.I.6
-
3
-
-
0035650534
-
Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus
-
Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH. Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2001, 50:2673-2681.
-
(2001)
Diabetes
, vol.50
, pp. 2673-2681
-
-
Song, Z.1
Levin, B.E.2
McArdle, J.J.3
Bakhos, N.4
Routh, V.H.5
-
4
-
-
0014683812
-
Glucose and osmosensitive neurons of the rat hypothalamus
-
Oomura Y, Ono H, Ooyama H, Wayner MJ. Glucose and osmosensitive neurons of the rat hypothalamus. Nature 1969, 222:282-284.
-
(1969)
Nature
, vol.222
, pp. 282-284
-
-
Oomura, Y.1
Ono, H.2
Ooyama, H.3
Wayner, M.J.4
-
5
-
-
3242765290
-
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides
-
Wang R, Liu X, Hentges ST, Dunn-Meynell AA, Levin BE, Wang W, Routh VH. The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 2004, 53:1959-1965.
-
(2004)
Diabetes
, vol.53
, pp. 1959-1965
-
-
Wang, R.1
Liu, X.2
Hentges, S.T.3
Dunn-Meynell, A.A.4
Levin, B.E.5
Wang, W.6
Routh, V.H.7
-
6
-
-
34147139847
-
Glucose, insulin and leptin signaling pathways modulate nitric oxide (NO) synthesis in glucose-inhibited (GI) neurons in the ventromedial hypothalamus (VMH)
-
Canabal DD, Song Z, Potian JG, Beuve A, McArdle JJ, Routh VH. Glucose, insulin and leptin signaling pathways modulate nitric oxide (NO) synthesis in glucose-inhibited (GI) neurons in the ventromedial hypothalamus (VMH). Am J Physiol Regul Integr Comp Physiol 2006, 292:R1418-R1428.
-
(2006)
Am J Physiol Regul Integr Comp Physiol
, vol.292
-
-
Canabal, D.D.1
Song, Z.2
Potian, J.G.3
Beuve, A.4
McArdle, J.J.5
Routh, V.H.6
-
7
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
8
-
-
17844391064
-
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
-
Fisher SJ, Bruning JC, Lannon S, Kahn CR. Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 2005, 54:1447-1451.
-
(2005)
Diabetes
, vol.54
, pp. 1447-1451
-
-
Fisher, S.J.1
Bruning, J.C.2
Lannon, S.3
Kahn, C.R.4
-
9
-
-
33745208032
-
Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia- induced hormonal counterregulation
-
McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS. Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia- induced hormonal counterregulation. J Clin Invest 2006, 116:1723-1730.
-
(2006)
J Clin Invest
, vol.116
, pp. 1723-1730
-
-
McCrimmon, R.J.1
Song, Z.2
Cheng, H.3
McNay, E.C.4
Weikart-Yeckel, C.5
Fan, X.6
Routh, V.H.7
Sherwin, R.S.8
-
10
-
-
33751192694
-
Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus (VMN)
-
Song Z, Routh VH. Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus (VMN). Am J Physiol Regul Integr Comp Physiol 2006, 291:R1283-R1287.
-
(2006)
Am J Physiol Regul Integr Comp Physiol
, vol.291
-
-
Song, Z.1
Routh, V.H.2
-
11
-
-
0033944152
-
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
-
Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford MLJ. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000, 3:757-758.
-
(2000)
Nat Neurosci
, vol.3
, pp. 757-758
-
-
Spanswick, D.1
Smith, M.A.2
Mirshamsi, S.3
Routh, V.H.4
Ashford, M.L.J.5
-
12
-
-
66149083518
-
Insulin blunts the response of glucose-excited (GE) neurons in the ventrolateral-ventromedial hypothalamic nucleus (VL-VMN) to decreased glucose
-
Cotero VE, Routh VH. Insulin blunts the response of glucose-excited (GE) neurons in the ventrolateral-ventromedial hypothalamic nucleus (VL-VMN) to decreased glucose. Am J Physiol Endocrinol Metab 2009, 296:E1101-E1109.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Cotero, V.E.1
Routh, V.H.2
-
13
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG, Seeley RJ, Schwartz MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2003, 52:227-231.
-
(2003)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
Olson, R.4
Baskin, D.G.5
Myers, M.G.6
Seeley, R.J.7
Schwartz, M.W.8
-
14
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999, 104:447-457.
-
(1999)
J Clin Invest
, vol.104
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.W.2
Clemont, A.3
Feener, E.P.4
Hein, K.D.5
Igarashi, M.6
Yamauchi, T.7
White, M.F.8
King, G.L.9
-
15
-
-
0037288941
-
Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities
-
Niswender KD, Schwartz MW. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 2003, 24:1-10.
-
(2003)
Front Neuroendocrinol
, vol.24
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
16
-
-
0036797873
-
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
-
Ding VD, Qureshi SA, Szalkowski D, Li Z, Biazzo-Ashnault DE, Xie D, Liu K, Jones AB, Moller DE, Zhang BB. Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator. Biochem J 2002, 367:301-306.
-
(2002)
Biochem J
, vol.367
, pp. 301-306
-
-
Ding, V.D.1
Qureshi, S.A.2
Szalkowski, D.3
Li, Z.4
Biazzo-Ashnault, D.E.5
Xie, D.6
Liu, K.7
Jones, A.B.8
Moller, D.E.9
Zhang, B.B.10
-
17
-
-
0034711277
-
Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators
-
Qureshi SA, Ding V, Li Z, Szalkowski D, Biazzo-Ashnault DE, Xie D, Saperstein R, Brady E, Huskey S, Shen X, Liu K, Xu L, Salituro GM, Heck JV, Moller DE, Jones AB, Zhang BB. Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. J Biol Chem 2000, 275:36590-36595.
-
(2000)
J Biol Chem
, vol.275
, pp. 36590-36595
-
-
Qureshi, S.A.1
Ding, V.2
Li, Z.3
Szalkowski, D.4
Biazzo-Ashnault, D.E.5
Xie, D.6
Saperstein, R.7
Brady, E.8
Huskey, S.9
Shen, X.10
Liu, K.11
Xu, L.12
Salituro, G.M.13
Heck, J.V.14
Moller, D.E.15
Jones, A.B.16
Zhang, B.B.17
-
18
-
-
0036174499
-
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
-
Air EL, Strowski MZ, Benoit SC, Conarello SL, Salituro GM, Guan XM, Liu K, Woods SC, Zhang BB. Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med 2002, 8:179-183.
-
(2002)
Nat Med
, vol.8
, pp. 179-183
-
-
Air, E.L.1
Strowski, M.Z.2
Benoit, S.C.3
Conarello, S.L.4
Salituro, G.M.5
Guan, X.M.6
Liu, K.7
Woods, S.C.8
Zhang, B.B.9
-
19
-
-
9244225116
-
Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes
-
Strowski MZ, Li Z, Szalkowski D, Shen X, Guan XM, Juttner S, Moller DE, Zhang BB. Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes. Endocrinology 2004, 145:5259-5268.
-
(2004)
Endocrinology
, vol.145
, pp. 5259-5268
-
-
Strowski, M.Z.1
Li, Z.2
Szalkowski, D.3
Shen, X.4
Guan, X.M.5
Juttner, S.6
Moller, D.E.7
Zhang, B.B.8
-
20
-
-
0028101988
-
Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals
-
Silver IA, Erecinska M. Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 1994, 14:5068-5076.
-
(1994)
J Neurosci
, vol.14
, pp. 5068-5076
-
-
Silver, I.A.1
Erecinska, M.2
-
21
-
-
2642641299
-
Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons
-
Silver IA, Erecinska M. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophysiol 1998, 79:1733-1745.
-
(1998)
J Neurophysiol
, vol.79
, pp. 1733-1745
-
-
Silver, I.A.1
Erecinska, M.2
-
22
-
-
12144275681
-
Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
-
Song Z, Routh VH. Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2005, 54:15-22.
-
(2005)
Diabetes
, vol.54
, pp. 15-22
-
-
Song, Z.1
Routh, V.H.2
-
23
-
-
33646012618
-
The effects of oleic-acid (OA) on distinct populations of neurons in the hypothalamic arcuate nucleus (ARC) are dependent on extracellular glucose levels
-
Wang R, Cruciani-Guglielmacci C, Migrenne S, Magnan C, Cotero VE, Routh VH. The effects of oleic-acid (OA) on distinct populations of neurons in the hypothalamic arcuate nucleus (ARC) are dependent on extracellular glucose levels. J Neurophysiol 2005, 55:1491-1498.
-
(2005)
J Neurophysiol
, vol.55
, pp. 1491-1498
-
-
Wang, R.1
Cruciani-Guglielmacci, C.2
Migrenne, S.3
Magnan, C.4
Cotero, V.E.5
Routh, V.H.6
-
24
-
-
0003518480
-
-
New York, NY, J. Wiley & Sons
-
Segel IH. Enzyme Kinetics 1975, New York, NY, J. Wiley & Sons
-
(1975)
Enzyme Kinetics
-
-
Segel, I.H.1
-
25
-
-
0035950093
-
Intracellular signalling key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW. Intracellular signalling key enzyme in leptin-induced anorexia. Nature 2001, 413:794-795.
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers, M.G.5
Schwartz, M.W.6
-
26
-
-
0033786596
-
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
-
Shao J, Yamashita H, Qiao L, Friedman JE. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. J Endocrinol 2000, 167:107-115.
-
(2000)
J Endocrinol
, vol.167
, pp. 107-115
-
-
Shao, J.1
Yamashita, H.2
Qiao, L.3
Friedman, J.E.4
-
27
-
-
0031440266
-
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
-
Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997, 390:521-525.
-
(1997)
Nature
, vol.390
, pp. 521-525
-
-
Spanswick, D.1
Smith, M.A.2
Groppi, V.E.3
Logan, S.D.4
Ashford, M.L.J.5
-
28
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996, 379:632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
29
-
-
0023691211
-
Reproductive tract and pancreatic norepinephrine levels in pre- and overt-diabetic C57BL/KsJ mice: relationship to body weight, blood glucose, serum insulin, and reproductive dysfunction
-
Garris DR. Reproductive tract and pancreatic norepinephrine levels in pre- and overt-diabetic C57BL/KsJ mice: relationship to body weight, blood glucose, serum insulin, and reproductive dysfunction. Proc Soc Exp Biol Med 1988, 189:79-83.
-
(1988)
Proc Soc Exp Biol Med
, vol.189
, pp. 79-83
-
-
Garris, D.R.1
-
30
-
-
0028597457
-
The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic gluconeogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice
-
Kodama H, Fujita M, Yamazaki M, Yamaguchi I. The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic gluconeogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice. Jpn J Physiol 1994, 66:281-287.
-
(1994)
Jpn J Physiol
, vol.66
, pp. 281-287
-
-
Kodama, H.1
Fujita, M.2
Yamazaki, M.3
Yamaguchi, I.4
-
31
-
-
48249087344
-
Brain-derived neurotrophic factor (BDNF) prevents the development of diabetes in prediabetic mice
-
Yamanaka M, Itakura Y, Tsuchida A, Nakagawa T, Taiji M. Brain-derived neurotrophic factor (BDNF) prevents the development of diabetes in prediabetic mice. Biomed Res 2008, 29:147-153.
-
(2008)
Biomed Res
, vol.29
, pp. 147-153
-
-
Yamanaka, M.1
Itakura, Y.2
Tsuchida, A.3
Nakagawa, T.4
Taiji, M.5
-
32
-
-
27844457564
-
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
-
Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 2005, 146:5341-5349.
-
(2005)
Endocrinology
, vol.146
, pp. 5341-5349
-
-
Buchanan, J.1
Mazumder, P.K.2
Hu, P.3
Chakrabarti, G.4
Roberts, M.W.5
Yun, U.J.6
Cooksey, R.C.7
Litwin, S.E.8
Abel, E.D.9
-
33
-
-
0029131574
-
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
-
Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995, 96:1658-1663.
-
(1995)
J Clin Invest
, vol.96
, pp. 1658-1663
-
-
Frederich, R.C.1
Lollmann, B.2
Hamann, A.3
Napolitano-Rosen, A.4
Kahn, B.B.5
Lowell, B.B.6
Flier, J.S.7
-
34
-
-
0242268888
-
Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia
-
De Vries MG, Arseneau LM, Lawson ME, Beverly JL. Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia. Diabetes 2003, 52:2767-2773.
-
(2003)
Diabetes
, vol.52
, pp. 2767-2773
-
-
De Vries, M.G.1
Arseneau, L.M.2
Lawson, M.E.3
Beverly, J.L.4
-
35
-
-
0035042796
-
ATP-sensitive potassium channels in hypothalamic neurons play an essential role in the maintenance of glucose homeostasis by controlling glucagon release and food intake
-
Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft FM, Minokoshi Y, Roeper J, Seino S. ATP-sensitive potassium channels in hypothalamic neurons play an essential role in the maintenance of glucose homeostasis by controlling glucagon release and food intake. Nat Neurosci 2001, 5:507-512.
-
(2001)
Nat Neurosci
, vol.5
, pp. 507-512
-
-
Miki, T.1
Liss, B.2
Minami, K.3
Shiuchi, T.4
Saraya, A.5
Kashima, Y.6
Horiuchi, M.7
Ashcroft, F.M.8
Minokoshi, Y.9
Roeper, J.10
Seino, S.11
|