Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission

Journal of Cellular Physiology

Volumn 201, Issue 3, 2004, Pages 470-482

  Tonachini, Laura ^a   Monticone, Massimiliano ^a,b   Puri, Claudia ^b   Tacchetti, Carlo ^b   Pinton, Paolo ^c   Rizzuto, Rosario ^c   Cancedda, Ranieri ^a,b   Tavella, Sara ^b   Castagnola, Patrizio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PROLINE; PROTEIN CHPPR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DAMAGE; CELL DIFFERENTIATION; CELL STRUCTURE; CHICK EMBRYO; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; IMMUNOELECTRON MICROSCOPY; MITOCHONDRION; MUSCLE MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SUBMITOCHONDRIAL PARTICLE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHICKENS; CHONDROCYTES; COMPUTER SIMULATION; HUMANS; HYPERTROPHY; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDES; PROTEIN TRANSPORT; PROTON-MOTIVE FORCE; RNA, MESSENGER; SEQUENCE ALIGNMENT;

EID: 7544242337     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20126     Document Type: Article

References (20)

1. Altschul SF, Gish W, et al. 1990. Basic local alignment search tool. J Mol Biol 215:403-410.
2. Castagnola P, Dozin B, et al. 1988. Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro. J Cell Biol 106:461-467.
3. Chiesa A, Rapizzi E, et al. 2001. Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signaling. Biochem J 355:1-12.
4. Claros MG, Vincens P. 1996. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem 241:779-786.
5. Evan GI, Lewis GK, et al. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol 5:3610-3616.
6. Griparic L, van der Bliek AM. 2001. The many shapes of mitochondrial membranes. Traffic 2:235-244.
7. Iiizumi M, Hirofumi A, et al. 2002. Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Cancer Res 62:1246-1250.
8. Kay BK, Williamson MP, et al. 2000. The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains. Faseb J 14:231-241.
9. Lawrie AM, Rizzuto R, et al. 1996. A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J Biol Chem 271:10753-10759.
10. 2+ transients that modulate secretion. Nat Cell Biol 2:57-61.
11. Nomura N, Miyajima N, et al. 1994. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res 1:27-35.
12. Nunnari J, Marshall WF, et al. 1997. Mitochondrial transmission during mating in Saccaromyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol Biol Cell 8:1233-1242.
13. Quarto R, Campanile G, et al. 1997. Modulation of commitment, proliferation, and differentiation of chondrogenic cells in defined culture medium. Endocrinology 138:4966-4976.
14. Rizzuto R, Brini M, et al. 1995. Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells. Curr Biol 5:635-642.
15. 2+ responses. Science 280:1763-1766.
16. Schiaffino MV, d'Addio M, et al. 1999. Ocular albinism: Evidence for a defect in an intracellular signal transduction system. Nat Genet 23:108-112.
17. Slot JW, Geuze HJ. 1984. Gold markers for single and double immunolabeling of ultrathin cryosections. In: Polak JM, Varndell IM, editors. Immunolabeling for electron microscopy. Amsterdam, NL: Elsevier. pp 129-142.
18. Tonachini L, Monticone M, et al. 2002. Chondrocyte protein with a poly-proline region (CHPPR) is a novel protein expressed by chondrocytes in vitro and in vivo. Biochim Biophys Acta 1577:421-429.
19. Westermann B. 2002. Merging mitochondria matters: Cellular role and molecular machinery of mitochondral fusion. EMBO Rep 3:527-531.
20. Williamson MP. 1994. The structure and function of proline-rich regions in proteins. Biochem J 297:249-260.