An overview of divalent cation and citrate handling by the kidney

Nephron - Physiology

Volumn 98, Issue 2, 2004, Pages

  Unwina, R J ^a   Capasso, G ^b   Shirley, D G ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Calcium; Citrate; Magnesium; Renal stones

Indexed keywords

ACETAZOLAMIDE; CALCIUM ION; CARRIER PROTEIN; CITRIC ACID; DIVALENT CATION; MAGNESIUM ION; PARATHYROID HORMONE; PEPTIDE HORMONE; SODIUM DICARBOXYLATE COTRANSPORTER; UNCLASSIFIED DRUG; VITAMIN D;

ACID BASE BALANCE; AEROBIC METABOLISM; BASOLATERAL MEMBRANE; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; DIETARY INTAKE; GLOMERULUS FILTRATION; HENLE LOOP; HORMONAL REGULATION; HUMAN; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE CELL; KIDNEY TUBULE EXCRETION; MAGNESIUM EXCRETION; POTASSIUM DEPLETION; PRIORITY JOURNAL; REVIEW; URINARY EXCRETION;

CATIONS, DIVALENT; CITRATES; HUMANS; KIDNEY;

EID: 7544236577     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080259     Document Type: Review

References (23)

1. Friedman PA: Renal calcium metabolism; in Seldin DW, Giebisch G (eds): The Kidney: Physiology and Pathophysiology, ed 3. Philadelphia, Lippincott Williams & Wilkins, 2000, pp 1749-1789.
2. Hebert SC: Extracellular calcium-sensing receptor: Implications for calcium and magnesium handling in the kidney. Kidney Int 1996;50:2129-2139.
3. 2+-ATPase pump in rat kidney. Am J Physiol 1992;263:F7-F14.
4. 2+ reabsorption in the distal nephron. Annu Rev Physiol 2002;64:529-549.
5. 2+ transport proteins in kidney. Kidney Int 2003;64:555-564.
6. Costanzo LS: Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport. Am J Physiol 1985;248:F527-F535.
7. Rizzo M, Capasso G, Bleich M, Pica A, Grimaldi D, Bindels RJM, Greger R: Effect of chronic metabolic acidosis on calbindin expression along the rat distal tubule. J Am Soc Nephrol 2000;11:203-210.
8. Quamme GA, de Rouffignac C: Renal magnesium handling; in Seldin DW, Giebisch G (eds): The Kidney: Physiology and Pathophysiology, ed 3. Philadelphia, Lippincott Williams & Wilkins, 2000, pp 1711-1729.
9. 2+ resorption. Science 1999;285:103-106.
10. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, Sheffield VC: Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 2002;31:171-174.
11. Dai L-J, Ritchie G, Kerstan D, Kang HS, Cole DEC, Quamme GA: Magnesium transport in the renal distal convoluted tubule. Physiol Rev 2001;81:51-84.
12. Hamm LL: Renal handling of citrate. Kidney Int 1990;38:728-735.
13. Brennan TS, Klahr S, Hamm LL: Citrate transport in rabbit nephron. Am J Physiol 1986;251:F683-F689.
14. Pajor AM: Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol 1999;61:663-682.
15. Chen X, Tsukaguchi H, Chen X-Z, Berger UV, Hediger MA: Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter. J Clin Invest 1999;103:1159-1168.
16. Dedmon RE, Wrong O: The excretion of organic anion in renal tubular acidosis with particular reference to citrate. Clin Sci 1962;22:19-32.
17. Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA, Pajor AM, Alpern RJ: Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int 2000;58:206-215.
18. Simpson DP: Citrate excretion: A window on renal metabolism. Am J Physiol 1983;244:F223-F234.
19. Hamm LL, Hering-Smith KS: Pathophysiology of hypocitraturic nephrolithiasis. Endocrinol Metab Clins N Am 2002;31:885-893.
20. Levi M, McDonald LA, Preisig PA, Alpern RJ: Chronic K depletion stimulates rat renal brushborder membrane Na-citrate cotransporter. Am J Physiol 1991;261:F767-F773.
21. - co-transport in rat renal cortex. J Clin Invest 1990;86:1076-1083.
22. Rudman D, Kutner MH, Redd SC, Waters WC, Gerron GG, Bleier J: Hypocitraturia in calcium nephrolithiasis. J Clin Endocrinol Metab 1982;55:1052-1057.
23. Mossetti G, Vuotto P, Rendina D, Numis FG, Viceconti R, Giordano F, Cioffi M, Scopacasa F, Nunziata V: Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis. J Intern Med 2003;253:194-200.