Genetics of obesity;Aspectos genéticos da obesidade

Revista de Nutricao

Volumn 17, Issue 3, 2004, Pages 327-338

  Marques Lopes, Iva ^a   Marti, Amelia ^a   Moreno Aliaga, María Jesús ^a   Martínez, Alfredo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Association and linkage studies; Genes; Mutation; Obesity; Obesity genetic models; Polymorphism

Indexed keywords

CALORIC INTAKE; CHRONIC DISEASE; DIET; ENERGY EXPENDITURE; ENVIRONMENTAL FACTOR; FEEDING BEHAVIOR; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; HUMAN; LIFESTYLE; OBESITY; PHYSICAL ACTIVITY; REVIEW; RISK FACTOR;

ANIMALIA;

EID: 7544236528     PISSN: 14155273     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1415-52732004000300006     Document Type: Review

References (36)

1. Martínez JA, Frühbeck G. Regulation of energy balance and adiposity: a model with new approaches. J Physiol Biochem 1996; 52:255-8.
2. Marques-Lopes I, Ansorena D, Astiasaran I, Forga L, Martínez JA. Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men. Am J Clin Nutr 2001; 73:253-61.
3. Corbalan MS, Marti A, Forga L, Martinez-Gonzalez MA, Martinez JA. Beta(2)-Adrenergic receptor mutation and abdominal obesity risk: effect modification by gender and HDL-cholesterol. Eur J Nutr 2002; 41:114-8.
4. Bouchard C, Pérusse L, Rice T, Rao DC. The genetics of human obesity. In: Bray GA, Bouchard C, James WPT. Handbook of obesity. New York: Marcel Dekker; 1998. p. 157-85.
5. Hirsch J, Leibel RL. The genetics of obesity. Hosp Pract 1998; 33(3):55-9.
6. Bray G, Bouchard C. Genetics of human obesity: research directions. FASEB J 1997; 11:937-45.
7. Orera M. Aspectos genéticos de la obesidade. In: Moreno B, Monereo S, Álvarez J. Obesidad: presente y futuro. Madrid: Biblioteca Aula Médica; 1997. p.51-69.
8. Macho-Azcarate T, Marti A, Gonzalez A, Martinez JA, Ibañez J. Gln27Glu polymorphism in the beta2 adrenergic gene and lipid metabolism during exercise in obese women. Int J Obes Relat Metab Disord 2002; 26:1434-41.
9. Snyder EE, Walts B. Perusse L, Chagnon YC, Weisnagel SJ, Rankinen T, et al. The human obesity gene map: the 2003 update. Obes Res 2004; 12:369-439.
10. Comuzzie AG, Allison DB. The search for human obesity genes. Science 1998; 280:1374-7.
11. Chagnon Y, Pérusse L, Bouchard C. Familial aggregation of obesity, candidate genes and quantitative trait loci. Curr Opin Lipid 1997; 8:205-11.
12. Inui A. Transgenic approach to the study of body weight regulation. Pharmacol Rev 2000; 52:35-61.
13. Bouchard C, Tremblay A. Genetic influences on the response of body fat distribution to positive and negative energy balances in human identical twins. J Nutr 1997; 127:943S-7S.
14. Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab 2002; 87:4442-6.
15. Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, et al. Harrison's principles of internal medicine. New York: McGraw Hill; 1998.
16. Romeo CM. Genética humana. Bilbao: Universal Deusto; 1995.
17. Macho-Azcarate T, Marti del Moral A, Martinez Hernandez JA. Genetic studies of obesity in humans. Med Clin (Barc) 2000; 115:103-10.
18. Daniel H. Genomics and proteomics: importance for the future of nutrition research. Br J Nutr 2002; 87(Suppl 2):S305-11.
19. Edvardsson U, Alexandersson M, Brockenhuus von Lowenhielm H, Nystrom AC, Ljung B, Nilsson F, et al. A proteome analysis of livers from obese (ob/ob) mice treated with the peroxisome proliferator WY14,643. Electrophoresis 1999; 20(4-5):935-42.
20. Sanchez JC, Chiappe D, Converset V, Hoogland C, Binz PA, Paesano S, et al. The mouse SWISS-2D PAGE database: a tool for proteomics study of diabetes and obesity. Proteomics 2001; 1:36-63.
21. Moreno MJ, Martí A, García-Foncillas J, Martínez JA. DNA hybridization arrays: a powerful technology for nutritional and obesity research. Br J Nutr 2001; 86:119-22.
22. GDB™ Genome Database database [online] 2002 [cited 2003]. Baltimore (Maryland, USA): Johns Hopkins University, 1190. Available from: http://gdbwww.gdb.org/-2002
23. Online Mendelian Inheritance in Man, OMIM™. Center for Medical Genetics, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information. Bethesda: National Library of Medicine; 2002.
24. Beales PL, Kopelman PG. Obesity genes. Clin Endocrinol 1996; 45:373-8.
25. Leibel RL, Chung WK, Chua SC. The molecular genetics of rodent single gene obesities. J Biol Chem 1997; 272:31937-40.
26. Naggert J, Harris T, North M. The genetics of obesity. Curr Op Gene Dev 1997; 7:398-404.
27. Kulkarmi RN, Bruning JC, Winay JN, Postc C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999; 96:329-39.
28. Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol 2002; 57:1-9.
29. Marti A, Larrarte E, Novo FJ, Garcia M, Martinez JA. UCP2 muscle gene transfer modifies mitochondrial membrane potential. Int J Obes Relat Metab Disord 2001; 25(1):68-74.
30. Lopes IM, Forga L, Martínez JA. Effects of leptin resistance on acute fuel metabolism after a high carbohydrate load in lean and overweight young men. J Am Coll Nutr 2001; 20(6):643-8.
31. Wauters M, Considine RV, Chagnon M, Mertens I, Rankinen T, Bouchard C, et al. Leptin levels, leptin receptor gene polymorphism, and energy metabolism in women. Obes Res 2002; 10:394-400.
32. Hasstedt SJ, Hoffman M, Leppert MF, Elbein SC. Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet 1997; 61:668-77.
33. Farooqi S, Rau H, Whitehead J, O'Rahilly S. ob gene mutations and human obesity. Proc Nutr Soc 1998; 57:471-5.
34. Ristow M, Müller-Wieland M, Pfeiffer A, Krone W, Kahn R. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 1998; 339:953-9.
35. García F, Margareto J, Marti A, Martínez JA, De Miguel C. Expresión diferencial de genes en la obesidad inducida por la dieta en ratas. Proc SEB 1998; p.169.
36. Clément K, Dina CH, Basdevant A, Chastang N, Pelloux V, Lahlou N, et al. A Sib-Pair Analysis Study of 15 Candidate Genes in French Families With Morbib Obesity. Diabetes 1999; 48:398-02.