Photon-timing detector module for single-molecule spectroscopy with 60-ps resolution

IEEE Journal on Selected Topics in Quantum Electronics

Volumn 10, Issue 4, 2004, Pages 788-795

  Rech, Ivan ^a   Luo, Guobin ^b   Ghioni, Massimo ^a   Yang, Haw ^b   Xie, Xiaoliang Sunney ^b   Cova, Sergio ^a  

^a POLITECNICO DI MILANO   (Italy)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Avalanche photodiode; Picosecond timing; Single molecule; Single photon; Single photon timing module (SPTM)

Indexed keywords

AVALANCHE DIODES; ELECTRIC BREAKDOWN; ELECTRON TRANSITIONS; FLUORESCENCE; PELTIER EFFECT; PHOTOMULTIPLIERS; PROTEINS; QUANTUM THEORY; SIGNAL TO NOISE RATIO;

PHOTON-TIMING DETECTORS; PICOSECOND TIMING; SINGLE MOLECULES; SINGLE PHOTONS; SINGLE-PHOTON TIMING MODULE (SPTM);

PHOTONS;

EID: 7544229364     PISSN: 1077260X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSTQE.2004.833975     Document Type: Article

References (25)

1. L. Edman, U. Mets, and R. Rigler, "Conformational transitions monitored for single molecules in solution," in Proc. Nat. Acad. Sci. USA, vol. 93, 1996, pp. 6710-6715.
2. Phe molecule under physiological conditions," in Proc. Nat. Acad. Sci. USA, vol. 94, 1997, pp. 7932-7936.
3. H Yang, G. Luo, P. Karnchanaphanurach, T.-M. Louie, I. Rech, S. Cova, L. Xun, and X. S. Xie, "Protein conformational dynamics probed by single-molecule electron transfer," Science, vol. 302, pp. 262-266, 2003.
4. C. Eggeling, J. R. Fries, L. Brand, R. Gunther, and C. A. Seidel, "Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy," in Proc. Nat. Acad. Sci. USA. vol. 95. 1998, pp. 1556-1561.
5. F. Kohn, J. Hoftens, R. Granheid, M. Cotlet, K. Mullen, M. Van der Aaweraer, and F. C. De Schryver, "Excitation energy transfer in dendritic host-guest donor-acceptor systems." F. C. Chem. Phys. Chem., vol. 3, pp. 1005-1013, 2002.
6. M. Sauer, J. Arden-Jacoh, K. H. Drexhage, F. Göbel, U. Lieberwirth, K. Mühlegger, R. Müller, and J. Wolfram, "Time-resolved identification of individual mononucleotide molecules in aqueous solution with pulsed semiconductor lasers," C. Bioimaging, vol. 6, pp. 14-24, 1998.
7. C. Eggeling, S. Berger, L. Brand, J. R. Fries, J. Schaffer, A. Volkmer, and C. A. Seidel, "Data registration and selective analysis for single-molecule fluorescence spectroscopy using BIFI," J. Biotechnol., vol. 86, pp. 163-180, 2001.
8. M. Cotlet J. Hofkens, S. Habuchi, G. Dirix, M. Van Guyse, J. Michiels, J. Vanderleyden, and F. C. De Schryver, "Identification of different emitting species in the red fluorescent protein DsRed by means of ensemble and single-molecule spectroscopy." in Proc. Nat. Acad. Sci. USA, vol. 98, 2001, pp. 14398-14403.
9. H. Yang and X. S. Xie, "Probing singler-molecule dynamics photon by photon," J. Chem. Phys., vol. 117, pp. 10965-10979, 2002.
10. H. Dautet, P. Deschamps, B. Dion, A. D. MacGregor, D. MacSween, R. J. Mclntyre, C. Trottier, and P. P. Webb, "Photon counting techniques with silicon avalanche photodiodes," Appl. Opt., vol. 32, pp. 3894-3900, 1993.
11. L. Q. Li and L. M. Davis, "Single photon avalanche diode for single molecule detection," Rev. Sci. Instrum., vol. 64, pp. 1524-1529, 1993.
12. S. Cova, M. Ghioni, A. Lacaita, C. Samori, and F. Zappa, "Avalanche photodiodes and quenching circuits for single photon detection," Appl. Opt., vol. 35, pp. 1956-1976, 1996.
13. A. Lacaita, M. Ghioni, and S. Cova, "Double epitaxy improves single-photon avalanche diode performance," Electron. Lett., vol. 25, pp. 841-843, 1989.
14. S. Cova, M. Ghioni, A. Lotito, I. Rech, and F. Zappa, Evolution and prospect of single-photon avalanche diodes and quenching circuits, in NIST-ARDA Workshop Single-Photon Detectors, Gaithersburg, MD, Mar. 31-Apr. 1 2003.
15. P. Antognetti, S. Cova, and A Longoni, "A study of the operation and performances of an avalanche diode as a single photon detector," in Proc. 2nd Ispra Nuclear Electronics Symp. Stresa, Italy, May 20-23, 1975. Euratom EUR 537e, 453-456.
16. [161 S. Cova, A. Longoni, and A. Andreoni, "Toward picosecond resolution with single-photon avalanche diodes," Rev. Sci. Instrum., vol. 52, pp. 408-412, 1981.
17. F. Zappa, M. Ghioni, S. Cova, L. Varisco, B. Sinnis, A. Morrison, and A Mathewson, "Integrated array of avalanche photodiodes for single photon counting," in Proc. Eur. Solid State Device Res. Conf., Stuttgart, Germany, Sept. 22-24, 1997. ESSDERC97, 600-603.
18. E. Sciacca, A Giudice, D. Sanfilippo, F. Zappa, S. Lombarde, R. Consentino, C. Di Franco, M. Ghioni, G. Fallica, G. Bonanno, S. Cova, and E. Rimini, "Silicon planar technology for single-photon optical detectors," IEEE Trans. Electron Devices, vol. 50, pp. 918-925, 2003.
19. S. Cova, A. Lacaita, and G. Ripamonti, "Trapping phenomena in avalanche photodiodes on nanosecond scale," IEEE Trans. Electron. Device Lett., vol. 12, pp. 685-687, 1991.
20. A. Lacaita and M. Mastrapasqua, "Strong dependence of time resolution on detector diameter in single photon avalanche diodes," Electron. Lett., vol. 26, pp. 2053-2054, 1990.
21. G. Ripamonti and S. Cova, "Carrier diffusion effects in the time-response of a fast photodiode," Solid State Electron., vol. 28, pp. 925-931, 1985.
22. F. Zappa, A. Lotito, A. C. Giudice, S. Cova, and M. Ghioni, "Monolithic active-quenching and active-reset circuit for single-photon avalanche detectors," IEEE J. Solid-State Circuits, vol. 38, pp. 1298-1301, 2003.
23. F. Zappa, S. Cova, and M. Ghioni, "Monolithic circuit of active quenching and active reset for avalanche photodiodes,". Eur. Pat. Appl. n. 01200852.2-2217, Mar. 6. 2001.
24. T. A. Louis, G. H. Schatz, P. Klein-Bolting, A. R. Holzwarth, G. Ripamonti, and S. Cova, "Performance comparison of a single-photon avalanche diode with a microchannel-plate photomultiplier in time-correlated single-photon counting," Rev. Sci. Instrum., vol. 59, pp. 1148-1152, 1988.
25. S. A. Soper, L. M. Davis, and E. B. Shera, "Detection and identification of single molecules in solution," J. Opt. Soc. Amer. B, vol. 9, pp. 1761-1769, 1992.