Diagnostic utility of a low-dose gonadotropin-releasing hormone test in the context of puberty disorders

Hormone Research

Volumn 62, Issue 4, 2004, Pages 168-176

  Zevenhuijzen, H ^a   Kelnar, C J H ^a   Crofton, P M ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

Author keywords

Follicle stimulating hormone; Gonadotropin releasing hormone test; Hypogonadotropic hypogonadism; Luteinizing hormone; Precocious puberty; Premature thelarche; Puberty, constitutional delay

Indexed keywords

GONADOTROPIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENDOCRINE FUNCTION TEST; FEMALE; GONADOTROPIN RELEASE; GONADOTROPIN RELEASING HORMONE TEST; HORMONE RESPONSE; HUMAN; HYPOGONADISM; HYPOPHYSIS FUNCTION; MALE; PRECOCIOUS PUBERTY; PREPUBERTY; PRIORITY JOURNAL; PUBERTY DISORDERS; RETROSPECTIVE STUDY; SCREENING TEST;

ADOLESCENT; ADOLESCENT DEVELOPMENT; BREAST; CHILD; CHILD, PRESCHOOL; DEVELOPMENTAL DISABILITIES; DIAGNOSIS, DIFFERENTIAL; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOGONADISM; MALE; PUBERTY, DELAYED; PUBERTY, PRECOCIOUS; RETROSPECTIVE STUDIES;

EID: 7544228927     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080324     Document Type: Article

References (43)

1. Roger M, Lahlou N, Chaussain J-L: Gonadotropin-releasing hormone testing in pediatrics; in Ranke MB (ed): Diagnostics of Endocrine Function in Children and Adolescents. Heidelberg, J & J Verlag, 1996, pp 346-369.
2. Wu FCW, Butler GE, Kelnar CJH, Stirling HF, Huhtaniemi I: Patterns of pulsatile luteinizing hormone and follicle-stimulating hormone secretion in prepubertal (midchildhood) boys and girls and patients with idiopathic hypogonadotropic hypogonadism (Kallmann's syndrome): A study using an ultrasensitive timeresolved immunofluorometric assay. J Clin Endocrinol Metab 1991;72:1229-1237.
3. Wu FCW, Brown DC, Butler GE, Stirling HF, Kelnar CJH: Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys. J Clin Endocrinol Metab 1993;76:26-31.
4. Degros V, Cortet-Rudelli C, Soudan B, Dewailly D: The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty. Eur J Endocrinol 2003;149:23-29.
5. Dunkel L, Perheentupa J, Virtanen M, Mäenpää J: Gonadotropin-releasing hormone test and human chorionic gonadotropin test in the diagnosis of gonadotropin deficiency in prepubertal boys. J Pediatr 1985;107:388-392.
6. Dunkel L, Perheentupa J, Virtanen M, Mäenpää J: GnRH and HCG tests are both necessary in differential diagnosis of male delayed puberty. Am J Dis Child 1985;139:494-498.
7. Ehrmann DA, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky LL: A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty: Pilot studies. J Clin Endocrinol Metab 1989;69:963-967.
8. Ibanez L, Potau N, Zampolli M, Virdis R, Gussinye M, Carrascosa A, Saenger P, Vicens-Calvet E: Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: Comparison with the gonadotropin- releasing hormone test. J Clin Endocrinol Metab 1994;78:30-35.
9. Dickerman Z, Prager-Lewin R, Laron Z: Response of plasma LH and FSH to synthetic LHRH in children at various pubertal stages. Am J Dis Child 1976;130:634-638.
10. Job J-C, Chaussain J-L, Garnier PE: The use of luteinizing hormone-releasing hormone in pediatric patients. Horm Res 1977;8:171-187.
11. Vourtsis K, Illig R: The use of a low-dose LHRH test for the distinction of delayed adolescence and isolated gonadotropin deficiency. Helv Paediatr Acta 1982;37:437-447.
12. Oerter KE, Uriarte MM, Rose SR, Barnes KM, Cutler GB: Gonadotropin secretory dynamics during puberty in normal girls and boys. J Clin Endocrinol Metab 1990;71:1251-1258.
13. Wu FCW, Borrow SM, Nicol K, Elton R, Hunter WM: Ontogeny of pulsatile gonadotrophin secretion and pituitary responsiveness in male puberty in man: A mixed longitudinal and cross-sectional study. J Endocrinol 1989;123:347-359.
14. Cavallo A, Zhou XH: LHRH test in the assessment of puberty in normal children. Horm Res 1994;41:10-15.
15. Hoff JD, Lasley BL, Yen SSC: The functional relationship between priming and releasing actions of luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 1979;49:8-11.
16. Dunaif D, Mandeli J, Fluhr H, Dobrjansky A: The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. J Clin Endocrinol Metab 1988;66:131-139.
17. Bergendahl M, Aloi JA, Iranmanesh A, Mulligan TM, Veldhuis JD: Fasting suppresses pulsatile luteinizing hormone (LH) secretion and enhances orderliness of LH release in young but not older men. J Clin Endocrinol Metab 1998;83:1967-1975.
18. Wu FCW, Butler GE, Kelnar CJH, Sellar RE: Patterns of pulsatile luteinizing hormone secretion before and during the onset of puberty in boys: A study using an immunoradiometric assay. J Clin Endocrinol Metab 1990;70:629-637.
19. Wu FCW, Butler GE, Kelnar CJH, Huhtaniemi I, Veldhuis JD: Ontogeny of pulsatile gonadotropin releasing hormone secretion from midchildhood, through puberty, to adulthood in the human male: A study using deconvolution analysis and an ultrasensitive immunofluorometric assay. J Clin Endocrinol Metab 1996;81:1798-1805.
20. Kaufman JM, Giri M, Deslypere JM, Thomas G, Vermeulen A: Influence of age on the responsiveness of the gonadotrophs to luteinizing hormone-releasing hormone in males. J Clin Endocrinol Metab 1991;72:1255-1260.
21. Tanner JM: Growth at Adolescence, ed 2. Oxford, Blackwell, 1962.
22. Beck JR, Shultz EK: The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 1986;110:13-20.
23. Snyder PJ, Reitano JF, Utiger RD: Serum LH and FSH responses to synthetic gonadotropinreleasing hormone in normal men. J Clin Endocrinol Metab 1975;41:938-945.
24. Zwart AD, Urban RJ, Odell WD, Veldhuis JD: Contrasts in the gonadotropin-releasing hormone dose-response relationships for luteinizing hormone, follicle-stimulating hormone and •-subunit release in young versus older men: Appraisal with high-specificity immunoradiometric assay and deconvolution analysis. Eur J Endocrinol 1996;135:399-406.
25. Andersson A-M, Juul A, Petersen JH, Müller J, Groome NP, Skakkebaek NE: Serum inhibin B in healthy pubertal and adolescent boys: Relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. J Clin Endocrinol Metab 1997;82:3976-3981.
26. Crofton PM, Evans AEM, Groome NP, Taylor MRH, Holland CV, Kelnar CJH: Inhibin B in boys from birth to adulthood: Relationship with age, pubertal stage, FSH and testosterone. Clin Endocrinol (Oxf) 2002;56:215-221.
27. Albanese A, Stanhope R: Investigation of delayed puberty. Clin Endocrinol (Oxf) 1995;43:105-110.
28. Smals AGH, Hermus ARM, Boers GHJ, Pieters GFF, Benraad THJ, Kloppenborg PW: Predictive value of luteinizing hormone releasing hormone (LHRH) bolus testing before and after 36-hour pulsatile LHRH administration in the differential diagnosis of constitutional delay of puberty and male hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1994;78:602-608.
29. Jungman E, Trautermann C: The status of the gonadotropin releasing hormone test in differential diagnosis of delayed puberty in adolescents over 14 years of age. Med Klin (Munich) 1994;89:529-533.
30. Ghai K, Cara JF, Rosenfield RL: Gonadotropin releasing hormone agonist (nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teen-age boys - A clinical research center study. J Clin Endocrinol Metab 1995;80:2980-2986.
31. Kletter GB, Rolfes-Curl A, Goodpasture JC, Solish SB, Scott L, Henzl MR, Beitins IZ: Gonadotropin-releasing hormone agonist analog (nafarelin): A useful diagnostic agent for the distinction of constitutional growth delay from hypogonadotropic hypogonadism. J Pediatr Endocrinol Metab 1996;9:9-19.
32. Lanes R, Gunczler P, Osuna JA, Palacios A, Carrillo E, Ramirez X, Garcia C, Paoli M, Villaroel O: Effectiveness and limitations of the use of the gonadotropin-releasing hormone agonist leuprolide acetate in the diagnosis of delayed puberty in males. Horm Res 1997;48:1-4.
33. Kauschansky A, Dickerman Z, Phillip M, Weintrob N, Strich D: Use of GnRH agonist and human chorionic gonadotrophin tests for differentiating constitutional delayed puberty from gonadotrophin deficiency in boys. Clin Endocrinol (Oxf) 2002;56:603-607.
34. Manieri C, Marolda AR, Musso M, Pastorino R, Messina M: The GnRH 10 Ìg test promotes a maximal gonadotropic response in normal women. Gynecol Endocrinol 1992;6:167-170.
35. Dickerman Z, Prager-Lewin R, Laron Z: The plasma FSH and LH response to synthetic LHRH in normal pre-pubertal and early pubertal girls - A re-evaluation. Acta Endocrinol 1979;91:14-18.
36. Pescovitz OH, Hench KD, Barnes KM, Loriaux DL, Cutler GB: Premature thelarche and central precocious puberty: The relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 1988;67:474-479.
37. Rosenfield RL: Normal and almost normal precocious variations in pubertal development. Premature pubarche and premature thelarche revisited. Horm Res 1994;41(suppl 2):7-13.
38. Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, Municchi G: Progression of premature thelarche to central precocious puberty. J Pediatr 1995;126:11-14.
39. Stanhope R, Abdulwahid NA, Adams J, Brook CGD: Studies of gonadotrophin pulsatility and pelvic ultrasound examinations distinguish between isolated premature thelarche and central precocious puberty. Eur J Pediatr 1986;145:190-194.
40. Zipf WB, Kelch RP, Hopwood NJ, Spencer ML, Bacon GE: Suppressed responsiveness to gonadotropin-releasing hormone in girls with unsustained isosexual precocity. J Pediatr 1979;95:38-43.
41. Pasquino AM, Piccolo F, Scalamandre A, Malvaso M, Ortolani R, Boscherini B: Hypothalamic-pituitary-gonadotropic function in girls with premature thelarche. Arch Dis Child 1980;55:941-944.
42. Partsch CJ, Hummelink R, Lorenzen F, Sippell WG: The significance and characteristics of the LHRH test in diagnosing precocious puberty development in girls: The stimulated LH/FSH quotient differentiates between central precocious puberty and premature thelarche. Monatsschr Kinderheilkd 1989;137:284-288.
43. Pohlenz J, Habermehl P, Wemme H, Grimm W, Schonberger W: The differentiation between premature thelarche and pubertas praecox on the basis of clinical, hormonal and radiological findings. Dtsch Med Wochenschr 1994;119:1301-1306.