Statistical experimental design for bioprocess modeling and optimization analysis: Repeated-measures method for dynamic biotechnology process

Applied Biochemistry and Biotechnology

Volumn 135, Issue 2, 2006, Pages 101-115

  Lee, Kwang Min ^a   Gilmore, David F ^a  

^a ARKANSAS STATE UNIVERSITY   (United States)

Author keywords

Dynamic bioprocess; Empirical (statistical) model; Repeated measures (RM); Sphericity; Statistical experimental design

Indexed keywords

BIOTECHNOLOGY; COMPUTER SIMULATION; DATA REDUCTION; MATHEMATICAL MODELS; OPTIMIZATION;

DYNAMIC BIOPROCESS; EMPIRICAL (STATISTICAL) MODEL; REPEATED-MEASURES (RM); SPHERICITY; STATISTICAL EXPERIMENTAL DESIGN;

STATISTICAL METHODS;

ANALYSIS OF VARIANCE; ARTICLE; BIOREACTOR; BIOTECHNOLOGY; CELL CULTURE; ENVIRONMENTAL FACTOR; MEASUREMENT; MULTIVARIATE ANALYSIS; PLANNING; PLANT; PROCESS MODEL; PROCESS OPTIMIZATION; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL MODEL; UNIVARIATE ANALYSIS;

ANALYSIS OF VARIANCE; BIOREACTORS; BIOTECHNOLOGY; FERMENTATION; LIPIDS; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; RESEARCH DESIGN;

ANIMALIA;

EID: 33845542715     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1385/ABAB:135:2:101     Document Type: Article

References (20)

1. Haaland, P. D. (1989) Experimental Design in Biotechnology, Marcel Dekker, INC., New York, NY.
2. th ed., John Wiley & Sons, INC. New York, NY.
3. rd ed., John Wiley & Sons, INC., New York. NY.
4. nd ed., John Wiley & Sons, INC., New York, NY.
5. Krishna, C. and Nokes, S. E. (2001) J. Ind. Microbiol. Biotechnol. 26, 161-170.
6. Lee, K.-M. and Gilmore, D. F. (2005) Process Biochem. 40, 226-249.
7. Narang, S., Sahai, V., and Bisaria, V. (2001) J. Biosci. Bioeng. 91(4), 425-427.
8. Saxena, S. and Saxena, R. K. (2004) Biotechnol. Appl. Biochem. 39, 99-106.
9. Sundaran, B., Rao, U. B., and Boopathy, R. (2001) J. Biosci. Bioeng. 91(2), 123-128.
10. Dunn, I. J., Heinzle, E., Ingham, J., and Prenosil, J. E. (1992) Biological Reaction Engineering, VCH, New York, NY.
11. Dean, A. and Voss, D. (1999) Design and Analysis of Experiments, Springer-Verlag, New York, NY.
12. nd ed., Brooks/Cole, Pacific Crove, CA.
13. Oehlert, G. W. (2000) A First Course in Design and Analysis of Experiments, W. H. Freeman and Company, New York, NY.
14. Wu, C. F. J. and Hamada, M. (2000) Experiments: Planning, Analysis, and Parameter Design Optimization, John Wiley & Sons, INC., New York, NY.
15. Volesky, B. and Votruba, J. (1992) Modelling and Optimization of Fermentation Process, Elsevier Publisher B. V., Amsterdam, The Netherlands.
16. Baughman, D. R. and Liu, Y. A. (1995) Neural Networks in Bioprocessing and Chemical Engineering, Academic Press, San Diego, CA.
17. Chen, C., Heineken, K., Szeto, D., Ryll, T., Chamow, S., and Chung, J. D. (2003) Biotechnol. Prog. 19, 52-57.
18. Lee, K. M. and Gilmore, D. F. (2006) Appl. Biochem. Biotechnol. 133(2), 113-148.
19. Lee, K. M., Rhee, C. H., Kang, C. K., and Kim, J. H. (2006a) Appl. Biochem. Biotechnol., In production.
20. Lee, K. M., Rhee, C. H., Kang, C. K., and Kim, J. H. (2006b) Appl. Biochem. Biotechnol., In production.