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Volumn 13, Issue 1, 2010, Pages 86-92

To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EARLY SECRETORY ANTIGENIC TARGET 6; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PROTEIN SECA; VIRULENCE FACTOR;

EID: 75249096198     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2009.11.006     Document Type: Review
Times cited : (93)

References (50)
  • 2
    • 42149094416 scopus 로고    scopus 로고
    • Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
    • Tobin D.M., and Ramakrishnan L. Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cell Microbiol 10 (2008) 1027-1039
    • (2008) Cell Microbiol , vol.10 , pp. 1027-1039
    • Tobin, D.M.1    Ramakrishnan, L.2
  • 3
    • 0025081151 scopus 로고
    • Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis
    • Snapper S.B., Melton R.E., Mustafa S., Kieser T., and Jacobs Jr. W.R. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4 (1990) 1911-1919
    • (1990) Mol Microbiol , vol.4 , pp. 1911-1919
    • Snapper, S.B.1    Melton, R.E.2    Mustafa, S.3    Kieser, T.4    Jacobs Jr., W.R.5
  • 4
    • 33947357684 scopus 로고    scopus 로고
    • Recombineering in Mycobacterium tuberculosis
    • van Kessel J.C., and Hatfull G.F. Recombineering in Mycobacterium tuberculosis. Nat Methods 4 (2007) 147-152
    • (2007) Nat Methods , vol.4 , pp. 147-152
    • van Kessel, J.C.1    Hatfull, G.F.2
  • 5
    • 38849190026 scopus 로고    scopus 로고
    • Efficient point mutagenesis in mycobacteria using single-stranded DNA recombineering: characterization of antimycobacterial drug targets
    • van Kessel J.C., and Hatfull G.F. Efficient point mutagenesis in mycobacteria using single-stranded DNA recombineering: characterization of antimycobacterial drug targets. Mol Microbiol 67 (2008) 1094-1107
    • (2008) Mol Microbiol , vol.67 , pp. 1094-1107
    • van Kessel, J.C.1    Hatfull, G.F.2
  • 6
    • 36849063886 scopus 로고    scopus 로고
    • In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
    • Genes that are essential for M. tuberculosis growth, either in in vitro or in vivo, are thought to make up about 20% of the M. tuberculosis genome. Understanding how these 800 or so genes function during infection is important, but technically challenging because of their essential nature. This paper uses the Tet-inducible promoter systems to deplete the essential genes that encode for the core mycobacterial proteasome during mouse infection. They find that the proteasome is required for M. tuberculosis persistence during the chronic phase of infection in mice.
    • Gandotra S., Schnappinger D., Monteleone M., Hillen W., and Ehrt S. In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nat Med 13 (2007) 1515-1520. Genes that are essential for M. tuberculosis growth, either in in vitro or in vivo, are thought to make up about 20% of the M. tuberculosis genome. Understanding how these 800 or so genes function during infection is important, but technically challenging because of their essential nature. This paper uses the Tet-inducible promoter systems to deplete the essential genes that encode for the core mycobacterial proteasome during mouse infection. They find that the proteasome is required for M. tuberculosis persistence during the chronic phase of infection in mice.
    • (2007) Nat Med , vol.13 , pp. 1515-1520
    • Gandotra, S.1    Schnappinger, D.2    Monteleone, M.3    Hillen, W.4    Ehrt, S.5
  • 8
    • 64549137584 scopus 로고    scopus 로고
    • Improved tetracycline repressors for gene silencing in mycobacteria
    • Although Tet-ON and Tet-OFF inducible systems allow tight regulation of some mycobacterial genes, they show weak or no regulation of other mycobacterial genes. In this paper, the authors present updated versions of the Tet-ON and Tet-OFF inducible promoter systems, resulting in 50-fold better repression of reporter genes in both M. smegmatis and BCG.
    • Klotzsche M., Ehrt S., and Schnappinger D. Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic Acids Res 37 (2009) 1778-1788. Although Tet-ON and Tet-OFF inducible systems allow tight regulation of some mycobacterial genes, they show weak or no regulation of other mycobacterial genes. In this paper, the authors present updated versions of the Tet-ON and Tet-OFF inducible promoter systems, resulting in 50-fold better repression of reporter genes in both M. smegmatis and BCG.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1778-1788
    • Klotzsche, M.1    Ehrt, S.2    Schnappinger, D.3
  • 9
    • 70350494282 scopus 로고    scopus 로고
    • One-plasmid tunable co-expression for mycobacterial protein-protein interaction studies
    • In this paper, the authors construct a single plasmid containing a Tet-inducible promoter, and a constitutive promoter allowing for controlled coexpression of two genes. They optimize this system in M. smegmatis using Tet-inducible expression of gfp and constitutive expression of rfip from G. atermophilus as reporters. They then apply this technology to study the M. tuberculosis fatty acid desaturase complex in M. smegmatis.
    • Chang Y., Mead D., Dhodda V., Brumm P., and Fox B.G. One-plasmid tunable co-expression for mycobacterial protein-protein interaction studies. Protein Sci 18 11 (2009) 2316-2325. In this paper, the authors construct a single plasmid containing a Tet-inducible promoter, and a constitutive promoter allowing for controlled coexpression of two genes. They optimize this system in M. smegmatis using Tet-inducible expression of gfp and constitutive expression of rfip from G. atermophilus as reporters. They then apply this technology to study the M. tuberculosis fatty acid desaturase complex in M. smegmatis.
    • (2009) Protein Sci , vol.18 , Issue.11 , pp. 2316-2325
    • Chang, Y.1    Mead, D.2    Dhodda, V.3    Brumm, P.4    Fox, B.G.5
  • 10
    • 47249140823 scopus 로고    scopus 로고
    • A new twist on an old pathway - accessory Sec [corrected] systems
    • This review comprehensively addresses the accessory Sec secretion systems in both mycobacteria and Gram-positive pathogens, highlighting the similarities and differences. They also review the accessory Sec systems relative to virulence.
    • Rigel N.W., and Braunstein M. A new twist on an old pathway - accessory Sec [corrected] systems. Mol Microbiol 69 (2008) 291-302. This review comprehensively addresses the accessory Sec secretion systems in both mycobacteria and Gram-positive pathogens, highlighting the similarities and differences. They also review the accessory Sec systems relative to virulence.
    • (2008) Mol Microbiol , vol.69 , pp. 291-302
    • Rigel, N.W.1    Braunstein, M.2
  • 11
    • 34447505050 scopus 로고    scopus 로고
    • Identification of two Mycobacterium smegmatis lipoproteins exported by a SecA2-dependent pathway
    • Gibbons H.S., Wolschendorf F., Abshire M., Niederweis M., and Braunstein M. Identification of two Mycobacterium smegmatis lipoproteins exported by a SecA2-dependent pathway. J Bacteriol 189 (2007) 5090-5100
    • (2007) J Bacteriol , vol.189 , pp. 5090-5100
    • Gibbons, H.S.1    Wolschendorf, F.2    Abshire, M.3    Niederweis, M.4    Braunstein, M.5
  • 12
    • 47249130438 scopus 로고    scopus 로고
    • ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages
    • Hou J.M., D'Lima N.G., Rigel N.W., Gibbons H.S., McCann J.R., Braunstein M., and Teschke C.M. ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages. J Bacteriol 190 (2008) 4880-4887
    • (2008) J Bacteriol , vol.190 , pp. 4880-4887
    • Hou, J.M.1    D'Lima, N.G.2    Rigel, N.W.3    Gibbons, H.S.4    McCann, J.R.5    Braunstein, M.6    Teschke, C.M.7
  • 13
    • 65649143489 scopus 로고    scopus 로고
    • The accessory SecA2 system of Mycobacteria requires ATP binding and the canonical SecA1
    • Rigel N.W., Gibbons H.S., McCann J.R., McDonough J.A., Kurtz S., and Braunstein M. The accessory SecA2 system of Mycobacteria requires ATP binding and the canonical SecA1. J Biol Chem 284 (2009) 9927-9936
    • (2009) J Biol Chem , vol.284 , pp. 9927-9936
    • Rigel, N.W.1    Gibbons, H.S.2    McCann, J.R.3    McDonough, J.A.4    Kurtz, S.5    Braunstein, M.6
  • 14
    • 70649084984 scopus 로고    scopus 로고
    • Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8(+) T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice
    • Because BCG can cause disease in immunocompromised individuals it is unsafe as a vaccine in HIV-infected infants. A safer alternative may be the use of attenuated strains of M. tuberculosis. Here the authors evaluate the immunogenicity in mice of multiple potential vaccine strains, including a M. tuberculosis strain with deletions in the lysA and secA2 genes, which also expresses the HIV envelope antigen construct. They conclude that this combination may be a promising new vaccine platform.
    • Ranganathan U.D., Larsen M.H., Kim J., Porcelli S.A., Jacobs Jr. W.R., and Fennelly G.J. Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8(+) T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice. Vaccine 28 1 (2009) 152-161. Because BCG can cause disease in immunocompromised individuals it is unsafe as a vaccine in HIV-infected infants. A safer alternative may be the use of attenuated strains of M. tuberculosis. Here the authors evaluate the immunogenicity in mice of multiple potential vaccine strains, including a M. tuberculosis strain with deletions in the lysA and secA2 genes, which also expresses the HIV envelope antigen construct. They conclude that this combination may be a promising new vaccine platform.
    • (2009) Vaccine , vol.28 , Issue.1 , pp. 152-161
    • Ranganathan, U.D.1    Larsen, M.H.2    Kim, J.3    Porcelli, S.A.4    Jacobs Jr., W.R.5    Fennelly, G.J.6
  • 15
    • 0035231423 scopus 로고    scopus 로고
    • The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G + C Gram-positive bacteria
    • RESEARCH0044
    • Gey Van Pittius N.C., Gamieldien J., Hide W., Brown G.D., Siezen R.J., and Beyers A.D. The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G + C Gram-positive bacteria. Genome Biol 2 (2001) RESEARCH0044
    • (2001) Genome Biol , vol.2
    • Gey Van Pittius, N.C.1    Gamieldien, J.2    Hide, W.3    Brown, G.D.4    Siezen, R.J.5    Beyers, A.D.6
  • 16
    • 60049091769 scopus 로고    scopus 로고
    • ESX/type VII secretion systems and their role in host-pathogen interaction
    • This recent review focuses on the role of the ESX-1 system in virulence and host-pathogen interactions.
    • Simeone R., Bottai D., and Brosch R. ESX/type VII secretion systems and their role in host-pathogen interaction. Curr Opin Microbiol 12 (2009) 4-10. This recent review focuses on the role of the ESX-1 system in virulence and host-pathogen interactions.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 4-10
    • Simeone, R.1    Bottai, D.2    Brosch, R.3
  • 17
    • 47749109112 scopus 로고    scopus 로고
    • The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis
    • Coros A., Callahan B., Battaglioli E., and Derbyshire K.M. The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis. Mol Microbiol 69 (2008) 794-808
    • (2008) Mol Microbiol , vol.69 , pp. 794-808
    • Coros, A.1    Callahan, B.2    Battaglioli, E.3    Derbyshire, K.M.4
  • 18
    • 70350156606 scopus 로고    scopus 로고
    • ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria
    • DiGiuseppe Champion P.A., Champion M.M., Manzanillo P., and Cox J.S. ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria. Mol Microbiol 73 (2009) 950-962
    • (2009) Mol Microbiol , vol.73 , pp. 950-962
    • DiGiuseppe Champion, P.A.1    Champion, M.M.2    Manzanillo, P.3    Cox, J.S.4
  • 21
    • 59249088584 scopus 로고    scopus 로고
    • Polar localization of virulence-related Esx-1 secretion in mycobacteria
    • This paper provides the first visualization of the ESX-1 system in the mycobacterial cell, and interestingly shows that this system is localized to the cell poles. Moreover, they identify a novel ESX-1 substrate in M. marinum, Mh3864, which remains cell wall associated following secretion from the cell.
    • Carlsson F., Joshi S.A., Rangell L., and Brown E.J. Polar localization of virulence-related Esx-1 secretion in mycobacteria. PLoS Pathog 5 (2009) e1000285. This paper provides the first visualization of the ESX-1 system in the mycobacterial cell, and interestingly shows that this system is localized to the cell poles. Moreover, they identify a novel ESX-1 substrate in M. marinum, Mh3864, which remains cell wall associated following secretion from the cell.
    • (2009) PLoS Pathog , vol.5
    • Carlsson, F.1    Joshi, S.A.2    Rangell, L.3    Brown, E.J.4
  • 22
    • 4344596222 scopus 로고    scopus 로고
    • The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis
    • Flint J.L., Kowalski J.C., Karnati P.K., and Derbyshire K.M. The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. Proc Natl Acad Sci U S A 101 (2004) 12598-12603
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12598-12603
    • Flint, J.L.1    Kowalski, J.C.2    Karnati, P.K.3    Derbyshire, K.M.4
  • 24
    • 63049134798 scopus 로고    scopus 로고
    • Transcriptional analysis of ESAT-6 cluster 3 in Mycobacterium smegmatis
    • Maciag A., Piazza A., Riccardi G., and Milano A. Transcriptional analysis of ESAT-6 cluster 3 in Mycobacterium smegmatis. BMC Microbiol 9 (2009) 48
    • (2009) BMC Microbiol , vol.9 , pp. 48
    • Maciag, A.1    Piazza, A.2    Riccardi, G.3    Milano, A.4
  • 25
    • 73249128210 scopus 로고    scopus 로고
    • Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    • This paper thoroughly investigates the ESX-3 system in both M. smegmatis and BCG. The authors demonstrate that mycobacteria lacking ESX-3 are deficient in iron acquisition, and demonstrate that this is because of the synthesis of mycobactins that fail to bind iron. They provide the first indication that ESX-3 is a functional secretion system by showing ESX-3 dependent secretion of the ESAT-6 ortholog, EsxH. Finally, they demonstrate that ESX-3 is important for the growth of BCG in macrophages.
    • Siegrist M.S., Unnikrishnan M., McConnell M.J., Borowsky M., Cheng T.Y., Siddiqi N., Fortune S.M., Moody D.B., and Rubin E.J. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proc Natl Acad Sci U S A 106 (2009) 18792-18797. This paper thoroughly investigates the ESX-3 system in both M. smegmatis and BCG. The authors demonstrate that mycobacteria lacking ESX-3 are deficient in iron acquisition, and demonstrate that this is because of the synthesis of mycobactins that fail to bind iron. They provide the first indication that ESX-3 is a functional secretion system by showing ESX-3 dependent secretion of the ESAT-6 ortholog, EsxH. Finally, they demonstrate that ESX-3 is important for the growth of BCG in macrophages.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18792-18797
    • Siegrist, M.S.1    Unnikrishnan, M.2    McConnell, M.J.3    Borowsky, M.4    Cheng, T.Y.5    Siddiqi, N.6    Fortune, S.M.7    Moody, D.B.8    Rubin, E.J.9
  • 26
    • 70350445687 scopus 로고    scopus 로고
    • Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc
    • Serafini A., Boldrin F., Palu G., and Manganelli R. Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc. J Bacteriol 191 (2009) 6340-6344
    • (2009) J Bacteriol , vol.191 , pp. 6340-6344
    • Serafini, A.1    Boldrin, F.2    Palu, G.3    Manganelli, R.4
  • 27
    • 67651207964 scopus 로고    scopus 로고
    • Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families
    • This review focuses on the PE, PPE and PE_GRS genes in mycobacteria, and the recent discovery that some of these proteins are secreted by the ESX-5 system in M. marinum.
    • Bottai D., and Brosch R. Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families. Mol Microbiol 73 (2009) 325-328. This review focuses on the PE, PPE and PE_GRS genes in mycobacteria, and the recent discovery that some of these proteins are secreted by the ESX-5 system in M. marinum.
    • (2009) Mol Microbiol , vol.73 , pp. 325-328
    • Bottai, D.1    Brosch, R.2
  • 28
    • 58149179178 scopus 로고    scopus 로고
    • The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response
    • In this study, the authors evaluate the role of ESX-5 during M. marinum infection of macrophages. They find that unlike ESX-1, ESX-5 is not required for phagosomal escape of M. marinum into the cytosol. Rather, ESX-5 seems to be involved in the suppression of proinflammatory cytokines, and in the induction of IL-1β by M. marinum. Moreover, they find that ESX-5 is involved in suppressing innate immune cytokine secretion in a TLR-dependent manner.
    • Abdallah A.M., Savage N.D., van Zon M., Wilson L., Vandenbroucke-Grauls C.M., van der Wel N.N., Ottenhoff T.H., and Bitter W. The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response. J Immunol 181 (2008) 7166-7175. In this study, the authors evaluate the role of ESX-5 during M. marinum infection of macrophages. They find that unlike ESX-1, ESX-5 is not required for phagosomal escape of M. marinum into the cytosol. Rather, ESX-5 seems to be involved in the suppression of proinflammatory cytokines, and in the induction of IL-1β by M. marinum. Moreover, they find that ESX-5 is involved in suppressing innate immune cytokine secretion in a TLR-dependent manner.
    • (2008) J Immunol , vol.181 , pp. 7166-7175
    • Abdallah, A.M.1    Savage, N.D.2    van Zon, M.3    Wilson, L.4    Vandenbroucke-Grauls, C.M.5    van der Wel, N.N.6    Ottenhoff, T.H.7    Bitter, W.8
  • 29
    • 67651233950 scopus 로고    scopus 로고
    • PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
    • Using proteomics, the authors evaluate the ESX-3 secretome. Interestingly, they find that ESX-5 is required for the secretion of PE_PGRS and PPE proteins, as well as ESAT-6 like proteins. The PE_PGRS and PPE proteins represent a family of proteins unique to mycobacteria, which seem to be expanded in the genomes of pathogenic mycobacteria in particular.
    • Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C., Mahasha P.W., Jimenez C., Parra M., Cadieux N., Brennan M.J., Appelmelk B.J., et al. PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol 73 (2009) 329-340. Using proteomics, the authors evaluate the ESX-3 secretome. Interestingly, they find that ESX-5 is required for the secretion of PE_PGRS and PPE proteins, as well as ESAT-6 like proteins. The PE_PGRS and PPE proteins represent a family of proteins unique to mycobacteria, which seem to be expanded in the genomes of pathogenic mycobacteria in particular.
    • (2009) Mol Microbiol , vol.73 , pp. 329-340
    • Abdallah, A.M.1    Verboom, T.2    Weerdenburg, E.M.3    Gey van Pittius, N.C.4    Mahasha, P.W.5    Jimenez, C.6    Parra, M.7    Cadieux, N.8    Brennan, M.J.9    Appelmelk, B.J.10
  • 30
    • 67650132403 scopus 로고    scopus 로고
    • Hypoxia: a window into Mycobacterium tuberculosis latency
    • Rustad T.R., Sherrid A.M., Minch K.J., and Sherman D.R. Hypoxia: a window into Mycobacterium tuberculosis latency. Cell Microbiol 11 (2009) 1151-1159
    • (2009) Cell Microbiol , vol.11 , pp. 1151-1159
    • Rustad, T.R.1    Sherrid, A.M.2    Minch, K.J.3    Sherman, D.R.4
  • 32
    • 43049170080 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection
    • Shiloh M.U., Manzanillo P., and Cox J.S. Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. Cell Host Microbe 3 (2008) 323-330
    • (2008) Cell Host Microbe , vol.3 , pp. 323-330
    • Shiloh, M.U.1    Manzanillo, P.2    Cox, J.S.3
  • 34
    • 70350458719 scopus 로고    scopus 로고
    • Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria
    • Analysis of all sequenced mycobacterial genomes reveals that many genes of the DosR regulon are conserved amongst MTB complex and nontuberculous mycobacteria.
    • Lin M.Y., Reddy T.B., Arend S.M., Friggen A.H., Franken K.L., van Meijgaarden K.E., Verduyn M.J., Schoolnik G.K., Klein M.R., and Ottenhoff T.H. Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria. Infect Immun 77 (2009) 5071-5079. Analysis of all sequenced mycobacterial genomes reveals that many genes of the DosR regulon are conserved amongst MTB complex and nontuberculous mycobacteria.
    • (2009) Infect Immun , vol.77 , pp. 5071-5079
    • Lin, M.Y.1    Reddy, T.B.2    Arend, S.M.3    Friggen, A.H.4    Franken, K.L.5    van Meijgaarden, K.E.6    Verduyn, M.J.7    Schoolnik, G.K.8    Klein, M.R.9    Ottenhoff, T.H.10
  • 35
    • 70350048603 scopus 로고    scopus 로고
    • Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis
    • Gupta R.K., Thakur T.S., Desiraju G.R., and Tyagi J.S. Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. J Med Chem 52 (2009) 6324-6334
    • (2009) J Med Chem , vol.52 , pp. 6324-6334
    • Gupta, R.K.1    Thakur, T.S.2    Desiraju, G.R.3    Tyagi, J.S.4
  • 37
    • 65649087135 scopus 로고    scopus 로고
    • Dormant forms of Mycobacterium smegmatis with distinct morphology
    • Combined, both articles demonstrate that nontuberculous mycobacteria (BCG, M. marinum and M. smegmatis) grown into stationary phase or exposed to nutrient starvation form spore-like structures with biologic characteristics of spores. Microscopy shows that resuscitation by exposure to fresh medium is accompanied by apparent germination.
    • Anuchin A.M., Mulyukin A.L., Suzina N.E., Duda V.I., El-Registan G.I., and Kaprelyants A.S. Dormant forms of Mycobacterium smegmatis with distinct morphology. Microbiology 155 (2009) 1071-1079. Combined, both articles demonstrate that nontuberculous mycobacteria (BCG, M. marinum and M. smegmatis) grown into stationary phase or exposed to nutrient starvation form spore-like structures with biologic characteristics of spores. Microscopy shows that resuscitation by exposure to fresh medium is accompanied by apparent germination.
    • (2009) Microbiology , vol.155 , pp. 1071-1079
    • Anuchin, A.M.1    Mulyukin, A.L.2    Suzina, N.E.3    Duda, V.I.4    El-Registan, G.I.5    Kaprelyants, A.S.6
  • 38
    • 20444419421 scopus 로고    scopus 로고
    • Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
    • Rengarajan J., Bloom B.R., and Rubin E.J. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A 102 (2005) 8327-8332
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8327-8332
    • Rengarajan, J.1    Bloom, B.R.2    Rubin, E.J.3
  • 40
    • 39149104645 scopus 로고    scopus 로고
    • The role of resuscitation promoting factors in pathogenesis and reactivation of Mycobacterium tuberculosis during intra-peritoneal infection in mice
    • Biketov S., Potapov V., Ganina E., Downing K., Kana B.D., and Kaprelyants A. The role of resuscitation promoting factors in pathogenesis and reactivation of Mycobacterium tuberculosis during intra-peritoneal infection in mice. BMC Infect Dis 7 (2007) 146
    • (2007) BMC Infect Dis , vol.7 , pp. 146
    • Biketov, S.1    Potapov, V.2    Ganina, E.3    Downing, K.4    Kana, B.D.5    Kaprelyants, A.6
  • 41
    • 37749054878 scopus 로고    scopus 로고
    • The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro
    • Kana B.D., Gordhan B.G., Downing K.J., Sung N., Vostroktunova G., Machowski E.E., Tsenova L., Young M., Kaprelyants A., Kaplan G., et al. The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol Microbiol 67 (2008) 672-684
    • (2008) Mol Microbiol , vol.67 , pp. 672-684
    • Kana, B.D.1    Gordhan, B.G.2    Downing, K.J.3    Sung, N.4    Vostroktunova, G.5    Machowski, E.E.6    Tsenova, L.7    Young, M.8    Kaprelyants, A.9    Kaplan, G.10
  • 42
    • 51949110418 scopus 로고    scopus 로고
    • A Mycobacterium tuberculosis Rpf double-knockout strain exhibits profound defects in reactivation from chronic tuberculosis and innate immunity phenotypes
    • Russell-Goldman E., Xu J., Wang X., Chan J., and Tufariello J.M. A Mycobacterium tuberculosis Rpf double-knockout strain exhibits profound defects in reactivation from chronic tuberculosis and innate immunity phenotypes. Infect Immun 76 (2008) 4269-4281
    • (2008) Infect Immun , vol.76 , pp. 4269-4281
    • Russell-Goldman, E.1    Xu, J.2    Wang, X.3    Chan, J.4    Tufariello, J.M.5
  • 43
    • 35448989031 scopus 로고    scopus 로고
    • A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis
    • Hett E.C., Chao M.C., Steyn A.J., Fortune S.M., Deng L.L., and Rubin E.J. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Mol Microbiol 66 (2007) 658-668
    • (2007) Mol Microbiol , vol.66 , pp. 658-668
    • Hett, E.C.1    Chao, M.C.2    Steyn, A.J.3    Fortune, S.M.4    Deng, L.L.5    Rubin, E.J.6
  • 44
    • 40349106168 scopus 로고    scopus 로고
    • A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor
    • Depletion of RipA in M. smegmatis reversibly inhibited cell growth and resulted in the formation of filamentous bacteria potentially resulting from defective cell division. This phenotype could be complemented by ripA from M. tuberculosis.
    • Hett E.C., Chao M.C., Deng L.L., and Rubin E.J. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog 4 (2008) e1000001. Depletion of RipA in M. smegmatis reversibly inhibited cell growth and resulted in the formation of filamentous bacteria potentially resulting from defective cell division. This phenotype could be complemented by ripA from M. tuberculosis.
    • (2008) PLoS Pathog , vol.4
    • Hett, E.C.1    Chao, M.C.2    Deng, L.L.3    Rubin, E.J.4
  • 45
    • 33644761790 scopus 로고    scopus 로고
    • A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages
    • Gao L.Y., Pak M., Kish R., Kajihara K., and Brown E.J. A mycobacterial operon essential for virulence in vivo and invasion and intracellular persistence in macrophages. Infect Immun 74 (2006) 1757-1767
    • (2006) Infect Immun , vol.74 , pp. 1757-1767
    • Gao, L.Y.1    Pak, M.2    Kish, R.3    Kajihara, K.4    Brown, E.J.5
  • 46
    • 34250802980 scopus 로고    scopus 로고
    • Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
    • The first paper to directly show ubiquitin-derived peptides are bactericidal to intracellular mycobacteria. This identifies another component of the antimicrobial repertoire of macrophages and may explain one mechanism by which autophagous cells kill bacteria.
    • Alonso S., Pethe K., Russell D.G., and Purdy G.E. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc Natl Acad Sci USA 104 (2007) 6031-6036. The first paper to directly show ubiquitin-derived peptides are bactericidal to intracellular mycobacteria. This identifies another component of the antimicrobial repertoire of macrophages and may explain one mechanism by which autophagous cells kill bacteria.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6031-6036
    • Alonso, S.1    Pethe, K.2    Russell, D.G.3    Purdy, G.E.4
  • 49
    • 70350154469 scopus 로고    scopus 로고
    • Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides
    • Purdy G.E., Niederweis M., and Russell D.G. Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides. Mol Microbiol 73 (2009) 844-857
    • (2009) Mol Microbiol , vol.73 , pp. 844-857
    • Purdy, G.E.1    Niederweis, M.2    Russell, D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.