The thyrocyte-fibrocyte link: Closing the loop in the pathogenesis of graves' disease?

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 62-65

  Kahaly, George J ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CELL ADHESION MOLECULE; GAMMA INTERFERON; HEAT SHOCK PROTEIN; HLA ANTIGEN CLASS 2; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; PROSTAGLANDIN; THYROTROPIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

CELL DIFFERENTIATION; CELL PROLIFERATION; EDITORIAL; GRAVES DISEASE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

EID: 75149197249     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2405     Document Type: Editorial

References (20)

1. Weetman AP 2001 Determinants of autoimmune thyroid disease. Nat Immunol 2:769-770
2. Prabhakar BS, Bahn RS, Smith TJ 2003 Current perspective on the pathogenesis of Graves' disease and ophthalmopathy. Endocr Rev 24:802-835
3. Orgiazzi J 2007 Pathogenesis. In: Wiersinga WM, Kahaly GJ, eds. Graves' orbitopathy - a multidisciplinary approach. Basel, Switzerland; Karger Publishers; 41-56
4. Smith TJ, Koumas L, Gagnon A, Bell A, Sempowski GD, Phipps RP, Sorisky A 2002 Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 87:385-392
5. Cao HJ, Wang HS, Zhang Y, Lin HY, Phipps RP, Smith TJ 1998 Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: insights into potential pathogenic mechanisms of thyroid associated ophthalmopathy. J Biol Chem 273:29615-29625
6. Hansen C, Rouhi R, Förster G, Kahaly GJ 1999 Increased sulfatation of orbital glycosaminoglycans in Graves' ophthalmopathy. J Clin Endocrinol Metab 84:1409-1413
7. Bahn RS, Dutton CM, Natt N, Joba W, Spitzweg C, Heufelder AE 1998 Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopathy. J Clin Endocrinol Metab 83:998-1002
8. Smith TJ, Hoa N 2004 Immunoglobulins from patients with Graves' disease induce hyaluran synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-1 receptor. J Clin Endocrinol Metab 89:5076-5080
9. Pritchard J, Horst N, Cruikshank W, Smith TJ 2002 Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts. J Immunol 168:942-950
10. Pritchard J, Han R, Horst N, Cruikshank WW, Smith TJ 2003 Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the IgF-1 receptor pathway. J Immunol 170:6348-6354
11. Douglas RS, Gianoukakis AG, Kamat S, Smith TJ 2007 Aberrant expression of the IGF-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol 178:3281-3287
12. Tsui S, Naik V, Hoa N, Hwang CJ, Afifiyan NF, Sinha Hikim A, Gianoukakis AG, Douglas RS, Smith TJ 2008 Evidence for an association between thyroid stimulating hormone and insulin-like growth factor 1 receptor: a tale of two antigens implicated in Graves' disease. J Immunol 181:4397-4405
13. Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ 2010 Graves' disease is associated with increased generation of fibrocytes: evidence for their participation in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 95:430-438
14. Chesney J, Bacher M, Bender A, Bucala R 1997 The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naïve T cells in situ. Proc Natl Acad Sci USA 94:6307-6312
15. Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R 2004 Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 36:598-606
16. + fibrocytes: morphology, histogenesis and function. Curr Stem Cell Res Ther 2:221-227
17. Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM 2007 Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor γ. J Biol Chem 282:22910-22920
18. Wang HC, Klein JR 2001 Immune function of thyroid stimulating hormone and receptor. Crit Rev Immunol 21:323-337
19. Klein JR 2003 Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid. Autoimmunity 36:417-421
20. Hansen C, Fraiture B, Rouhi R, Otto E, Förster G, Kahaly GJ 1997 HPLC glycosaminoglycan analysis in patients with Graves' disease. Clin Sci 92:511-517