Is LOX-1 K167N polymorphism protective for coronary artery disease?

In Vivo

Volumn 23, Issue 6, 2009, Pages 969-973

  Kurnaz, Özlem ^a   Aydoǧan, Hülya Yilmaz ^a   Isbir, C Selim ^b   Tekeli, Atike ^b   Isbir, Turgay ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

CAD; Gene polymorphism; LOX 1; OLR1

Indexed keywords

ASPARAGINE; CELL SURFACE RECEPTOR; LYSINE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ADULT; AGED; ALLELE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DNA POLYMORPHISM; ENDOCYTOSIS; FEMALE; FOAM CELL; GENDER; HUMAN; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SMOOTH MUSCLE FIBER; TURKEY (REPUBLIC); VASCULAR ENDOTHELIUM;

EID: 75149189542     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Jain KS, Kathiravan MK, Somani RS and Shishoo CJ: The biology and chemistry of hyperlipidemia. Bioorg Med Chem 15: 4674-4699, 2007.
2. Trabetti E, Biscuola M, Cavallari U, Malerba G, Girelli D, Olivieri O, Martinelli N, Corrocher R and Pignatti PF: On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease. E J Hum Genet 14: 127-130, 2006
3. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y et al: An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-77, 1997.
4. Mehta JL, Chen J, Hermonat PL, Romeo F and Novelli G: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res 69: 36-45, 2006.
5. Vecchione L, Gargiu E, Borgiani P, Predazzi I, Mango R, Romeo F, Magnani M and Novelli G: Genotyping OLR1 gene: a genomic biomarker for cardiovascular diseases. Recent Pat Cardiovasc Drug Discovery 2: 147-151, 2007.
6. Chen M, Narumiya S, Masaki T and Sawamura T: Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density lipoprotein binding. Biochem J 355: 289-296, 2001.
7. Kataoka H, Kume N, Miyamoto S, Minami M, Morimoto M, Hayashida K, Hashimoto N and Kita T: Oxidized LDL modulates Bax/Bcl-2 through the lectin-like Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 21: 955-960, 2001.
8. Gillote KL, Hörkkö S, Witztum JL and Steinberg D: Oxidized phospolipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors. J Lipid Res 41: 824-833, 2000.
9. Ellis TJ, 2006, LOX-1 genotype, dietary fat intake, and aerobic exercise training: influence on endothelial function, oxidative stress, lipoprotein-lipids, and soluble LOX-1. Ph.D. Thesis. University of Maryland, MD, USA.
10. Tate S: Oxidized low-density lipoprotein receptor, LOX-1, on the endothelial cell-the receptor structure and functions of LOX-1 in atherogenesis. J Biol Macromol 7(2): 11-22, 2007.
11. Chen X and Du G: Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance. Chin Med J 120(5): 421-426, 2007.
12. Chen M, Masaki T and Sawamura T: LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol, Therapeut 95: 89-100, 2002.
13. Chen M and Sawamura T: Essential role of cytoplasmic sequences for cell surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J Mol Cell Cardiol 39: 553-561, 2005.
14. Murphy JE , Tedburry PR, Homer-Vanniasinkam S, Walker JH and Ponnambalam S: Biochemistry and cell biology of mamalian scavenger receptors. Atherosclerosis 182: 1-15, 2005.
15. Sentinelli F, Filippi E, Fallarino M, Romeo S, Fanelli M, Buzzetti R, Berni A and Baroni MG: The 3′-UTR C>T polymorphism of the oxidized LDL receptor 1 (OLR1) gene does not associate with coronary artery disease in Italian CAD patients or with the severity of coronary disease. Nut Metab Cardiovasc Dis 16: 345-352, 2006.
16. Hattori H, Sonoda A, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K and Suzuki N: G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. Brain Res 7727: 246-249, 2006.
17. Mango R, Clementi F, Borgiani P, Forleo G B, Federici M, Contino G, Giardina E, Garza L, Fahdi I E, Lauro R, Mehta J L, Novelli G and Romeo F: Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction. J Med Genet 40: 933-936, 2003.
18. Ohmori R, Momiyama Y, Nagano M, Taniguchi H, Egashira T, Yonemura A, Nakamura H, Kondo K and Ohsuzu F: An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease. Clin Cardiol 27(11): 641-644, 2004.
19. Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S et al: Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Biochem Biophys Res Commun 303: 247-250, 2003.
20. Miller SA, Dykes DD and Poleskey HS: Simples salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215, 1988.
21. Richmond W: Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 19(2): 1350-1356, 1973.
22. Mc Gowan MW, Artiss JD, Stranbergh DR and Zak B: A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 29(3): 538-542, 1983.