Insight into the molecular pathogenesis of hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma, provided by the analysis of their IGH rearrangements and somatic hypermutation patterns

British Journal of Haematology

Volumn 148, Issue 4, 2010, Pages 666-669

  Hockley, Sarah L ^a   Giannouli, Stavroula ^a   Morilla, Alison ^a   Wotherspoon, Andrew ^b   Morgan, Gareth J ^a   Matutes, Estella ^a   Gonzalez, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Hairy cell leukaemia; HCL variant; IGH rearrangements; Somatic hypermutation; Splenic marginal zone lymphoma

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

GENE LOCUS; GENE REARRANGEMENT; HAIRY CELL LEUKEMIA; HUMAN; LETTER; PATHOGENESIS; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; SPLENIC MARGINAL ZONE LYMPHOMA;

GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LEUKEMIA, HAIRY CELL; LYMPHOMA, B-CELL, MARGINAL ZONE; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPLENIC NEOPLASMS;

EID: 75149189505     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07962.x     Document Type: Letter

References (10)

1. Brezinschek, H.P., Foster, S.J., Brezinschek, R.I., Dorner, T., Domiati-Saad, R. Lipsky, P.E. (1997) Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. Journal of Clinical Investigation, 99, 2488 2501.
2. van Dongen, J.J., Langerak, A.W., Bruggemann, M., Evans, P.A., Hummel, M., Lavender, F.L., Delabesse, E., Davi, F., Schuuring, E., Garcia-Sanz, R., van Krieken, J.H., Droese, J., Gonzalez, D., Bastard, C., White, H.E., Spaargaren, M., Gonzalez, M., Parreira, A., Smith, J.L., Morgan, G.J., Kneba, M. Macintyre, E.A. (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, 17, 2257 2317.
3. Forconi, F., Sahota, S.S., Raspadori, D., Ippoliti, M., Babbage, G., Lauria, F. Stevenson, F.K. (2004) Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch. Blood, 104, 3312 3317.
4. Gonzalez, D., Gonzalez, M., Balanzategui, A., Sarasquete, M.E., Lopez-Perez, R., Chillon, M.C., Garcia-Sanz, R. San Miguel, J.F. (2005) Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma. Haematologica, 90, 906 913.
5. Kuppers, R., Klein, U., Hansmann, M.L. Rajewsky, K. (1999) Cellular origin of human B-cell lymphomas. New England Journal of Medicine, 341, 1520 1529.
6. Matutes, E., Wotherspoon, A. Catovsky, D. (2003) The variant form of hairy-cell leukaemia. Best Practice & Research. Clinical Haematology, 16, 41 56.
7. Schroeder, H.W., Jr. Dighiero, G. (1994) The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunology Today, 15, 288 294.
8. Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J. Vardiman, J.W. (2008) Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organisation Classification of Tumours. IARC Press, Lyon, France.
9. Tierens, A., Delabie, J., Malecka, A., Wang, J., Gruszka-Westwood, A., Catovsky, D. Matutes, E. (2003) Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations. American Journal of Pathology, 162, 681 689.
10. Weill, J.C., Weller, S. Reynaud, C.A. (2009) Human marginal zone B cells. Annual Review of Immunology, 27, 267 285.