Tumor infiltrating lymphocytes but not serum pituitary antibodies are associated with poor clinical outcome after surgery in patients with pituitary adenoma

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 289-296

  Lupi, Isabella ^a   Manetti, Luca ^a   Caturegli, Patrizio ^b   Menicagli, Michele ^a   Cosottini, Mirco ^a   Iannelli, Aldo ^a   Acerbi, Giovanni ^a   Bevilacqua, Generoso ^a   Bogazzi, Fausto ^a   Martino, Enio ^a  

^a UNIVERSITY OF PISA   (Italy)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CORTICOTROPIN; GROWTH HORMONE; THYROTROPIN;

ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CONTROLLED STUDY; HUMAN; HYPOPHYSIS ADENOMA; HYPOPHYSITIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PREVALENCE; PRIORITY JOURNAL; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR RECURRENCE;

EID: 75149182253     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1583     Document Type: Article

References (39)

1. Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, Duray PH, Steinberg SM, Allison JP, Davis TA, Rosenberg SA 2003 Cancer regression and autoimmunity induced by cytotoxic Tlymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 100:8372-8377
2. Matsubayashi S, Kawai K, Matsumoto Y, Mukuta T, Morita T, Hirai K, Matsuzuka F, Kakudoh K, Kuma K, Tamai H 1995 The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland. J Clin Endocrinol Metab 80:3421-3424
3. Le Bitoux MA, Stamenkovic I 2008 Tumor-ho73t interactions: the role of inflammation. Histochem Cell Biol 130:1079-1090
4. Kosmaczewska A, Ciszak L, Potoczek S, Frydecka I 2008 The significance of Treg cells in defective tumor immunity. Arch Immunol Ther Exp (Warsz) 56:3181-191
5. Uppaluri R, Dunn GP, Lewis Jr JS 2008 Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers. Cancer Immun 8:16
6. Heshmati HM, Kujas M, Casanova S, Wollan PC, Racadot J, Van Effenterre R, Derome PJ, Turpin G 1998 Prevalence of lymphocytic infiltrate in 1400 pituitary adenomas. Endocr J 45:357-361
7. De Bellis A, Bizzarro A, Conte M, Perrino S, Coronella C, Solimeno S, Sinisi AM, Stile LA, Pisano G, Bellastella A 2003 Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases. J Clin Endocrinol Metab 88:650-654
8. De Bellis A, Colao A, Pivonello R, Savoia A, Battaglia M, Ruocco G, Tirelli G, Lombardi G, Bellastella A, Bizzarro A 2007 Antipituitary antibodies in idiopathic hyperprolactinemic patients. Ann NY Acad Sci 1107:129-135
9. De Bellis A, Sinisi AA, Conte M, Coronella C, Bellastella G, Esposito D, Pasquali D, Ruocco G, Bizzarro A, Bellastella A 2007 Antipituitary antibodies against gonadotropin-secreting cells in adult male patients with apparently idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 92:604-607
10. Keda YM, Krjukova IV, Ilovaiskaia IA, Morozova MS, Fofanova OV, Babarina MB, Marova EI, Pankov YA, Kandror VI 2002 Antibodies to pituitary surface antigens during various pituitary disease states. J Endocrinol 175:417-423
11. Kikuchi T, Yabe S, Kanda T, Kobayashi I 2000 Antipituitary antibodies as pathogenetic factors in patients with pituitary disorders. Endocr J 47:407-416
12. Komatsu M, Kondo T, Yamauchi K, Yokokawa N, Ichikawa K, Ishihara M, Aizawa T, Yamada T, Imai Y, Tanaka K, et al 1988 Antipituitary antibodies in patients with the primary empty sella syndrome. J Clin Endocrinol Metab 67:633-638
13. Lupi I, Broman KW, Tzou SC, Gutenberg A, Martino E, Caturegli P 2008 Novel autoantigens in autoimmune hypophysitis. Clin Endocrinol (Oxf) 69:269-278
14. Mau M, Phillips TM, Ratner RE 1993 Presence of anti-pituitary hormone antibodies in patients with empty sella syndrome and pituitary tumours. Clin Endocrinol (Oxf) 38:495-500
15. Scherbaum WA, Schrell U, Gluck M, Fahlbusch R, Pfeiffer EF 1987 Autoantibodies to pituitary corticotropin-producing cells: possible marker for unfavourable outcome after pituitary microsurgery for Cushing's disease. Lancet 1:1394-1398
16. Tanaka S, Tatsumi KI, Kimura M, Takano T, Murakami Y, Takao T, Hashimoto K, Kato Y, Amino N 2002 Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. Eur J Endocrinol 147:767-775
17. Tanaka S, Tatsumi KI, Takano T, Murakami Y, Takao T, Yamakita N, Tahara S, Teramoto A, Hashimoto K, Kato Y, Amino N 2003 Anti-α-enolase antibodies in pituitary disease. Endocr J 50:697-702
18. Yabe S, Kanda T, Hirokawa M, Hasumi S, Osada M, Fukumura Y, Kobayashi I 1998 Determination of antipituitary antibody in patients with endocrine disorders by enzyme-linked immunosorbent assay and Western blot analysis. J Lab Clin Med 132:25-31
19. Crock PA 1998 Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metab 83:609-618
20. Manetti L, Lupi I, Morselli LL, Albertini S, Cosottini M, Grasso L, Genovesi M, Pinna G, Mariotti S, Bogazzi F, Bartalena L, Martino E 2007 Prevalence and functional significance of antipituitary antibodies in patients with autoimmune and non-autoimmune thyroid diseases. J Clin Endocrinol Metab 92:2176-2181
21. Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR 2005 Autoimmune hypophysitis. Endocr Rev 26:599-614
22. Tatsumi KI, Tanaka S, Takano T, Tahara S, Murakami Y, Takao T, Hashimoto K, Kato Y, Teramoto A, Amino N 2003 Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma. Endocrine 22:335-340
23. Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P 2009 Pituitary and systemic autoimmunity in a case of intrasellar germinoma. Pituitary doi:19466616
24. Nelson BH 2008 The impact of T-cell immunity on ovarian cancer outcomes. Immunol Rev 222:101-116
25. Parker C, Milosevic M, Panzarella T, Banerjee D, Jewett M, Catton C, Tew-George B, Gospodarowicz M, Warde P 2002 The prognostic significance of the tumour infiltrating lymphocyte count in stage I testicular seminoma managed by surveillance. Eur J Cancer 38: 2014-2019
26. Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G 2003 Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.NEngl JMed348:203-213
27. Polydorides AD, Mukherjee B, Gruber SB, McKenna BJ, Appelman HD, Greenson JK 2008 Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer. Am J Surg Pathol 32:1661-1666
28. Cuthbertson DJ, Ritchie D, Crooks D, Main G, Smith C, Vora J, Eljamel MS, Leese GP 2008 Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. Endocr J 55: 729-735
29. Moskowitz SI, Hamrahian A, Prayson RA, Pineyro M, Lorenz RR, Weil RJ 2006 Concurrent lymphocytic hypophysitis and pituitary adenoma. Case report and review of the literature. J Neurosurg 105:309-314
30. McConnon JK, Smyth HS, Horvath E 1991 A case of sparsely granulated growth hormone cell adenoma associated with lymphocytic hypophysitis. J Endocrinol Invest 14:691-696
31. Ballian N, Chrisoulidou A, Nomikos P, Samara C, Kontogeorgos G, Kaltsas GA 2007 Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. J Endocrinol Invest 30:677-683
32. Nishikawa T, Takahashi JA, Shimatsu A, Hashimoto N 2007 Hypophysitis caused by Rathke's cleft cyst. Case report. Neurol Med Chir (Tokyo) 47:136-139
33. Yuyama R, Kojima H, Mizutani T, Suzuki Y, Miki Y 2002 [Secondary pan-hypophysitis caused by rupture of Rathke's cleft cyst: case report]. No Shinkei Geka 30:95-99
34. Schittenhelm J, Beschorner R, Psaras T, Capper D, Nägele T, Meyermann R, Saeger W, Honegger J, Mittelbronn M 2008 Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature. Neurosurg Rev 31:157-163
35. Puchner MJ, Ludecke DK, Saeger W 1994 The anterior pituitary lobe in patients with cystic craniopharyngiomas: three cases of associated lymphocytic hypophysitis. Acta Neurochir (Wien) 126:38-43
36. Takao T, Nanamiya W, Matsumoto R, Asaba K, Okabayashi T, Hashimoto K 2001 Antipituitary antibodies in patients with lymphocytic hypophysitis. Horm Res 55:288-292
37. Mou Z, He Y, Wu Y 2009 Immunoproteomics to identify tumor-associated antigens eliciting humoral response. Cancer Lett 278: 123-129
38. Tan EM, Zhang J 2008 Autoantibodies to tumor-associated antigens: reporters from the immune system. Immunol Rev 222:328-340
39. Zhong L, Coe SP, Stromberg AJ, Khattar NH, Jett JR, Hirschowitz EA 2006 Profiling tumor-associated antibodies for early detection of non-small cell lung cancer. J Thorac Oncol 1:513-519