The common genetic variant of luteinizing hormone has a longer serum half-life than the wild type in heterozygous women

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 383-389

  Wide, Leif ^a   Eriksson, Karin ^a   Sluss, Patrick M ^b   Hall, Janet E ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; N ACETYLGALACTOSAMINE; SIALIC ACID;

ARTICLE; ELECTROPHORETIC MOBILITY; GENETIC VARIABILITY; HALF LIFE TIME; HETEROZYGOSITY; PRIORITY JOURNAL; SULFONATION; WILD TYPE;

EID: 75149179018     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1679     Document Type: Article

References (26)

1. Pettersson K, Ding YQ, Huhtaniemi I 1992 An immunologically anomalous luteinizing hormone variant in a healthy women. J Clin Endocrinol Metab 74:164-171
2. Furui K, Suganuma N, Tsukahara SI, Asada Y, Kikkawa F, Tanaka M, Ozawa T, Tomoda Y 1994 Identification of two point mutations in the gene coding luteinizing hormone (LH) β-subunit, associated with immunologically anomalous LH variants. J Clin Endocrinol Metab 78:107-113
3. Okuda K, Yamada T, Imoto H, Komatsubara H, Sugimoto O1994 Antigenic alteration of an anomalous human luteinizing hormone caused by two chorionic gonadotropin-type amino-acid substitutions. Biochem Biophys Res Commun 200:584-590
4. Pettersson K, Mäkelä MM, Dahlén P, Lamminen T, Huoponen K, Huhtaniemi I 1994 Gene polymorphism found in the LH beta gene of an immunologically anomalous variant of human luteinizing hormone. Eur J Endocrinol 130(Suppl 2):S17.03 (Abstract)
5. Nilsson C, Jiang M, Pettersson K, Iitiä A,Mäkelä M, Simonsen H, Easteal S, Herrera RJ, Huhtaniemi I 1998 Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassays. Clin Endocrinol (Oxf) 49:369-376
6. Nilsson C, Pettersson K, Millar RP, Coerver KA, Matzuk MM, Huhtaniemi IT 1997 Worldwide frequency of a common genetic variant of luteinizing hormone: an international collaborative research. Fertil Steril 67:998-1004
7. Takahashi K, Kurioka H, Ozaki T, Kanasaki H, Kohsaka M, Miyazaki K, Karino K 1998 Increased prevalence of luteinizing hormone β-subunit variant in Japanese infertility patients.HumReprod 13:3338-3344
8. Takahashi K, Ozaki T, Okada M, Kurioka H, Kanasaki H, Miyazaki K 1999 Increased prevalence of luteinizing hormone β-subunit variant in patients with premature ovarian failure. Fertil Steril 71:96-101
9. Raivio T, Huhtaniemi I, Anttila R, Siimes MA, Hagenäs L, Nilsson C, Pettersson K, Dunkel L 1996 The role of luteinizing hormone-β gene polymorphism in the onset and progression of puberty in healthy boys. J Clin Endocrinol Metab 81:3278-3282
10. Wide L, Naessén T, Sundström-Poromaa I, Eriksson K 2007 Sulfonation and sialylation of gonadotropins inwomenduring the menstrual cycle, after menopause, and with polycystic ovarian syndrome and in men. J Clin Endocrinol Metab 92:4410-4417
11. Wide L, Eriksson K, Sluss PM, Hall JE 2009 Serum half-life of pituitary gonadotropins is decreased by sulfonation and increased by sialylation in women. J Clin Endocrinol Metab 94:958-964
12. Haavisto AM, Pettersson K, Bergendahl M, Virkamäki A, Huhtaniemi I 1995 Occurrence and biological properties of a common genetic variant of luteinizing hormone. J Clin Endocrinol Metab 80:1257-1263
13. 15→Thr) in human luteinizing hormone (LH) β-subunit on LH bioactivity in vitro and in vivo. Endocrinology 137:831-838
14. Manna PR, Joshi L, Reinhold VN, Aubert ML, Suganuma N, Pettersson K, Huhtaniemi IT 2002 Synthesis, purification and structural and functional characterization of recombinant form of a common genetic varaiant of luteinizing hormone. Hum Mol Genet 11:301-315
15. Sharpless JL, Supko JG, Martin KA, Hall JE 1999 Disappearance of endogenous luteinizing hormone is prolonged in postmenopausal women. J Clin Endocrinol Metab 84:688-694
16. Phillips DJ, Albertsson-Wikland K, Eriksson K, Wide L 1997 Changes in the isoforms of luteinizing hormone and follicle-stimulating hormone during puberty in normal children. J Clin Endocrinol Metab 82:3103-3106
17. Pettersson KS, Söderholm JR 1991 Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies. Clin Chem 37:333-340
18. Wide L 1985 Median charge and charge heterogeneity of human pituitary FSH, LH and TSH. I. Zone electrophoresis in agarose suspension. Acta Endocrinol (Copenh) 109:181-189
19. Nilsson CH, Kaleva M, Virtanen H, Haavisto AM, Pettersson K, Huhtaniemi IT 2001 Disparate response of wild-type and variant forms of LH to GnRH stimulation in individuals heterozygous for the LHβ variant allele. Human Reproduction 16:230-235
20. Phillips DJ, Wide L 1994 Serum gonadotropin isoforms become more basic after an exogenous challenge of gonadotropin-releasing hormone in children undergoing pubertal development. J Clin Endocrinol Metab 79:814-819
21. 4-4GalNAcβ1, 4GlcNAcβ1,2Manα that mediates rapid clearance of lutropin. Cell 67:1103-1110
22. 4 receptor. Proc Natl Acad Sci USA 97:9949-9954
23. Baenziger JU 1994 Protein-specific glycosyltransferases: how and why they do it! FASEB J 8:1019-1025
24. Smith PL, Baenziger JU 1992 Molecular basis of recognition by the glycoprotein hormone-specific N-acetylgalactosamine-transferase. Proc Natl Acad Sci USA 89:329-333
25. Mengeling BJ, Manzella SM, Baenziger JU 1995 A cluster of basic aminoacids within an α-helix is essential for α-subunit recognition by the glycoprotein hormone N-acetylgalactosaminyltransferase. Proc Natl Acad Sci USA 92:502-506
26. Weiss TJ, Steele PA, Umapathysivam K 1989 Perifusion of human granulosa-luteal cells: response to LH stimulation. Clin Endocrinol (Oxf) 31:285-294