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Volumn 137, Issue 3, 1996, Pages 831-838

Effects of the Mutations (Trp8→Arg and Ile15→Thr) in Human Luteinizing Hormone (LH) β-Subunit on LH Bioactivity in Vitro and in Vivo

Author keywords

[No Author keywords available]

Indexed keywords

LUTEINIZING HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; LUTEINIZING HORMONE RECEPTOR; PROGESTERONE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 0029669973     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.3.8603592     Document Type: Article
Times cited : (60)

References (52)
  • 1
    • 0023608873 scopus 로고
    • Two-monoclonal-antibody "sandwich"-type assay of human lutropin, with no cross reaction with choriogonadotropin
    • Odell WD, Griffin J 1987 Two-monoclonal-antibody "sandwich"-type assay of human lutropin, with no cross reaction with choriogonadotropin. Clin Chem 33:1603-1607
    • (1987) Clin Chem , vol.33 , pp. 1603-1607
    • Odell, W.D.1    Griffin, J.2
  • 2
    • 0025247957 scopus 로고
    • LH measurements by in vitro bioassay and highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism
    • Haavisto AM, Dunkel L, Pettersson K, Huhtaniemi I 1990 LH measurements by in vitro bioassay and highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Pediatr Res 27:211-214
    • (1990) Pediatr Res , vol.27 , pp. 211-214
    • Haavisto, A.M.1    Dunkel, L.2    Pettersson, K.3    Huhtaniemi, I.4
  • 3
    • 0014217281 scopus 로고
    • Diagnosis of allergy by an in-vitro test for allergen antibodies
    • Wide L, Bennich H, Johansson SGO 1967 Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet 2:1105-1107
    • (1967) Lancet , vol.2 , pp. 1105-1107
    • Wide, L.1    Bennich, H.2    Johansson, S.G.O.3
  • 4
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C 1975 Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 5
    • 0025829726 scopus 로고
    • Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies
    • Pettersson KS, Soderholm JR 1991 Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies. Clin Chem 37:333-340
    • (1991) Clin Chem , vol.37 , pp. 333-340
    • Pettersson, K.S.1    Soderholm, J.R.2
  • 6
    • 0026539397 scopus 로고
    • An immunologically anomalous luteinizing hormone variant in a healthy woman
    • Pettersson K, Ding Y-Q, Huhtaniemi I 1992 An immunologically anomalous luteinizing hormone variant in a healthy woman. J Clin Endocrinol Metab 74:164-171
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 164-171
    • Pettersson, K.1    Ding, Y.-Q.2    Huhtaniemi, I.3
  • 7
    • 0019729482 scopus 로고
    • Glycoprotein hormones: Structure and function
    • Pierce JG, Parsons TF 1981 Glycoprotein hormones: structure and function. Annu Rev Biochem 50:465-495
    • (1981) Annu Rev Biochem , vol.50 , pp. 465-495
    • Pierce, J.G.1    Parsons, T.F.2
  • 8
    • 0010495367 scopus 로고
    • Gonadotropin hormones of the adenohypophysis
    • Yen SSC, Jaffe RB (eds) Saunders, Philadelphia
    • Catt KJ, Pierce JG 1986 Gonadotropin hormones of the adenohypophysis. In: Yen SSC, Jaffe RB (eds) Reproductive Endocrinology. Saunders, Philadelphia, pp 75-114
    • (1986) Reproductive Endocrinology , pp. 75-114
    • Catt, K.J.1    Pierce, J.G.2
  • 9
    • 84995842414 scopus 로고
    • Identification of two point mutations in the gene coding luteinizing hormone (LH) β-subunit, associated with immunologically anomalous LH variants
    • Furui K, Suganuma N, Tsukahara S, Asada Y, Kikkawa F, Tanaka M, Ozawa T, Tomoda Y 1994 Identification of two point mutations in the gene coding luteinizing hormone (LH) β-subunit, associated with immunologically anomalous LH variants. J Clin Endocrinol Metab 78:107-113
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 107-113
    • Furui, K.1    Suganuma, N.2    Tsukahara, S.3    Asada, Y.4    Kikkawa, F.5    Tanaka, M.6    Ozawa, T.7    Tomoda, Y.8
  • 10
    • 0028919465 scopus 로고
    • Screening of the mutations in luteinizing hormone β-subunit in patients with menstrual disorders
    • Suganuma N, Furui K, Furuhashi M, Asada Y, Kikkawa F, Tomoda Y 1995 Screening of the mutations in luteinizing hormone β-subunit in patients with menstrual disorders. Fertil Steril 63:989-995
    • (1995) Fertil Steril , vol.63 , pp. 989-995
    • Suganuma, N.1    Furui, K.2    Furuhashi, M.3    Asada, Y.4    Kikkawa, F.5    Tomoda, Y.6
  • 11
    • 0008519414 scopus 로고
    • Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells
    • Matzuk MM, Krieger M, Corless CL, Boime I 1987 Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells. Proc Natl Acad Sci USA 84:6354-6358
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6354-6358
    • Matzuk, M.M.1    Krieger, M.2    Corless, C.L.3    Boime, I.4
  • 13
    • 0023941649 scopus 로고
    • The role of the asparagine-linked oligosaccharides of the a subunit in the secretion and assembly of human chorionic gonadotropin
    • Matzuk MM, Boime I 1988 The role of the asparagine-linked oligosaccharides of the a subunit in the secretion and assembly of human chorionic gonadotropin. J Cell Biol 106:1049-1059
    • (1988) J Cell Biol , vol.106 , pp. 1049-1059
    • Matzuk, M.M.1    Boime, I.2
  • 14
    • 0024813415 scopus 로고
    • Elimination of disulfide bonds affects assembly and secretion of the human chorionic gonadotropin β subunit
    • Suganuma N, Matzuk MM, Boime I 1989 Elimination of disulfide bonds affects assembly and secretion of the human chorionic gonadotropin β subunit. J Biol Chem 264:19302-19307
    • (1989) J Biol Chem , vol.264 , pp. 19302-19307
    • Suganuma, N.1    Matzuk, M.M.2    Boime, I.3
  • 15
    • 0028936554 scopus 로고
    • Role of the Pro-Leu-Arg motif in glycosylation of human gonadotropin α-subunit
    • Furuhashi M, Suzuki S, Tomoda Y, Suganuma N 1995 Role of the Pro-Leu-Arg motif in glycosylation of human gonadotropin α-subunit. Endocrinology 136:2270-2275
    • (1995) Endocrinology , vol.136 , pp. 2270-2275
    • Furuhashi, M.1    Suzuki, S.2    Tomoda, Y.3    Suganuma, N.4
  • 16
    • 0000150675 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 307:37-40
    • (1970) Nature , vol.307 , pp. 37-40
    • Laemmli, U.K.1
  • 17
    • 0019364734 scopus 로고
    • Characterization of several clonal lines of cultured Leydig tumor cells: Gonadotropin receptors and steroidogenic responses
    • Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108:88-95
    • (1981) Endocrinology , vol.108 , pp. 88-95
    • Ascoli, M.1
  • 18
    • 0021744546 scopus 로고
    • Na+ modulates the affinity of the lutropin/choriogonadotropin receptor
    • Buettner K, Ascoli M 1984 Na+ modulates the affinity of the lutropin/choriogonadotropin receptor. J Biol Chem 259: 15078-15084
    • (1984) J Biol Chem , vol.259 , pp. 15078-15084
    • Buettner, K.1    Ascoli, M.2
  • 19
    • 0019455997 scopus 로고
    • The dynamics of the steroidogenic response of perfused Leydig tumor cells to human chorionic gonadotropin, bovine luteinizing hormone, cholera toxin, and adenosine 3′,5′-cyclic monophosphate
    • Segaloff DL, Puett D, Ascoli M 1981 The dynamics of the steroidogenic response of perfused Leydig tumor cells to human chorionic gonadotropin, bovine luteinizing hormone, cholera toxin, and adenosine 3′,5′-cyclic monophosphate. Endocrinology 108:632-638
    • (1981) Endocrinology , vol.108 , pp. 632-638
    • Segaloff, D.L.1    Puett, D.2    Ascoli, M.3
  • 21
    • 0023855203 scopus 로고
    • One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats
    • Okada H, Heya T, Ogawa Y, Shimamoto T 1987 One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J Pharmacol Exp Ther 244:744-750
    • (1987) J Pharmacol Exp Ther , vol.244 , pp. 744-750
    • Okada, H.1    Heya, T.2    Ogawa, Y.3    Shimamoto, T.4
  • 23
    • 0024454312 scopus 로고
    • Mutagenesis and chimeric genes define determinants in the β subunits of human chorionic gonadotropin and lutropin for secretion and assembly
    • Matzuk MM, Spangler MM, Camel M, Suganuma N, Boime I 1989 Mutagenesis and chimeric genes define determinants in the β subunits of human chorionic gonadotropin and lutropin for secretion and assembly. J Cell Biol 109:1429-1438
    • (1989) J Cell Biol , vol.109 , pp. 1429-1438
    • Matzuk, M.M.1    Spangler, M.M.2    Camel, M.3    Suganuma, N.4    Boime, I.5
  • 24
    • 0026724205 scopus 로고
    • Receptor-binding regions in human glycoprotein hormones
    • Keutmann HT 1992 Receptor-binding regions in human glycoprotein hormones. Mol Cell Endocrinol 86:C1-C6
    • (1992) Mol Cell Endocrinol , vol.86
    • Keutmann, H.T.1
  • 25
    • 0024511030 scopus 로고
    • Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction
    • Matzuk MM, Keene JL, Boime I 1989 Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. J Biol Chem 264:2409-2414
    • (1989) J Biol Chem , vol.264 , pp. 2409-2414
    • Matzuk, M.M.1    Keene, J.L.2    Boime, I.3
  • 26
    • 0024404680 scopus 로고
    • Disruption of N-linked glycosylation of bovine luteinizing hormone β-subunit by site-directed mutagenesis dramatically increases its intracellular stability but does not affect biological activity of the secreted heterodimer
    • Kaetzel DM, Virgin JB, Clay CM, Nilson JH 1989 Disruption of N-linked glycosylation of bovine luteinizing hormone β-subunit by site-directed mutagenesis dramatically increases its intracellular stability but does not affect biological activity of the secreted heterodimer. Mol Endocrinol 3:1765-1774
    • (1989) Mol Endocrinol , vol.3 , pp. 1765-1774
    • Kaetzel, D.M.1    Virgin, J.B.2    Clay, C.M.3    Nilson, J.H.4
  • 27
    • 0011336683 scopus 로고
    • Human chorionic gonadotropin
    • Parsons JA (ed) University Park Press, Baltimore
    • Canfield RE, Birken S, Morse JH, Morgan FJ 1978 Human chorionic gonadotropin. In: Parsons JA (ed) Peptide Hormones. University Park Press, Baltimore, pp 299-315
    • (1978) Peptide Hormones , pp. 299-315
    • Canfield, R.E.1    Birken, S.2    Morse, J.H.3    Morgan, F.J.4
  • 28
    • 0022833831 scopus 로고
    • Functional states of the luteinizing hormone/choriogonadotropin-receptor complex in rat Leydig cells
    • Combarnous Y, Guillou F, Martinot N 1986 Functional states of the luteinizing hormone/choriogonadotropin-receptor complex in rat Leydig cells. J Biol Chem 261:6868-6871
    • (1986) J Biol Chem , vol.261 , pp. 6868-6871
    • Combarnous, Y.1    Guillou, F.2    Martinot, N.3
  • 30
  • 31
    • 0028116115 scopus 로고
    • Mutagenesis of cysteine residues in the human gonadotropin α subunit: Roles of individual disulfide bonds in secretion, assembly, and biologic activity
    • Furuhashi M, Ando H, Bielinska M, Pixley NR, Shikone T, Hsueh AJW, Boime I 1994 Mutagenesis of cysteine residues in the human gonadotropin α subunit: roles of individual disulfide bonds in secretion, assembly, and biologic activity. J Biol Chem 269:25543-25548
    • (1994) J Biol Chem , vol.269 , pp. 25543-25548
    • Furuhashi, M.1    Ando, H.2    Bielinska, M.3    Pixley, N.R.4    Shikone, T.5    Hsueh, A.J.W.6    Boime, I.7
  • 32
    • 0026042543 scopus 로고
    • Expression of human luteinizing hormone (LH) receptor: Interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species
    • Jia X, Oikawa M, Bo M, Tanaka T, Ny T, Boime I, Hsueh AJW 1991 Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species. Mol Endocrinol 5:759-768
    • (1991) Mol Endocrinol , vol.5 , pp. 759-768
    • Jia, X.1    Oikawa, M.2    Bo, M.3    Tanaka, T.4    Ny, T.5    Boime, I.6    Hsueh, A.J.W.7
  • 34
    • 0015414389 scopus 로고
    • The in vivo behavior of human chorionic gonadotropin after dissociation into subunits
    • Braunstein GD, Vaitukaitis JL, Ross GT 1972 The in vivo behavior of human chorionic gonadotropin after dissociation into subunits. Endocrinology 91:1030-1036
    • (1972) Endocrinology , vol.91 , pp. 1030-1036
    • Braunstein, G.D.1    Vaitukaitis, J.L.2    Ross, G.T.3
  • 35
    • 0020683104 scopus 로고
    • Role of carbohydrate in human chorionic gonadotropin: Effect of deglycosylation on the subunit interaction and its in vitro and in vivo biological properties
    • Kalyan NK, Bahl OP 1983 Role of carbohydrate in human chorionic gonadotropin: effect of deglycosylation on the subunit interaction and its in vitro and in vivo biological properties. J Biol Chem 258: 67-74
    • (1983) J Biol Chem , vol.258 , pp. 67-74
    • Kalyan, N.K.1    Bahl, O.P.2
  • 36
    • 0016527576 scopus 로고
    • The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake
    • RA
    • Ascoli M, RA Liddle RA, Puett D 1975 The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. Mol Cell Endocrinol 3:21-74
    • (1975) Mol Cell Endocrinol , vol.3 , pp. 21-74
    • Ascoli, M.1    Liddle, R.A.2    Puett, D.3
  • 37
    • 0015861421 scopus 로고
    • Role of the kidney in the metabolism of luteinizing hormone
    • de Krester DM, Atkins RC, Paulsen CA 1972 Role of the kidney in the metabolism of luteinizing hormone. J Endocrinol 58:425-434
    • (1972) J Endocrinol , vol.58 , pp. 425-434
    • Krester, D.M.1    Atkins, R.C.2    Paulsen, C.A.3
  • 39
    • 0023034787 scopus 로고
    • Differences in the metabolic clearance of pituitary and serum thyrotropin (TSH) derived from euthyroid and hypothyroid rats: Effects of chemical deglycosylation of pituitary TSH
    • Constant RB, Weintraub BD 1986 Differences in the metabolic clearance of pituitary and serum thyrotropin (TSH) derived from euthyroid and hypothyroid rats: effects of chemical deglycosylation of pituitary TSH. Endocrinology 119:2720-2727
    • (1986) Endocrinology , vol.119 , pp. 2720-2727
    • Constant, R.B.1    Weintraub, B.D.2
  • 40
    • 0014872812 scopus 로고
    • Human pituitary follicle-stimulating hormone: Distribution, plasma clearance and urinary excretion as determined by radioimmunoassay
    • Amin HK, Hunter WM 1970 Human pituitary follicle-stimulating hormone: distribution, plasma clearance and urinary excretion as determined by radioimmunoassay. J Endocrinol 48:307-317
    • (1970) J Endocrinol , vol.48 , pp. 307-317
    • Amin, H.K.1    Hunter, W.M.2
  • 41
    • 0025020754 scopus 로고
    • The biological role of the carboxyl-terminal extension of human chorionic gonadotropin β-subunit
    • Matzuk MM, Hsueh AJW, LaPolt P, Tsafriri A, Keene JL, Boime I 1990 The biological role of the carboxyl-terminal extension of human chorionic gonadotropin β-subunit. Endocrinology 126:376-383
    • (1990) Endocrinology , vol.126 , pp. 376-383
    • Matzuk, M.M.1    Hsueh, A.J.W.2    LaPolt, P.3    Tsafriri, A.4    Keene, J.L.5    Boime, I.6
  • 42
    • 0023930204 scopus 로고
    • Asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. II. Distribution of sulphated and sialyated oligosaccharides on bovine, ovine and human pituitary glycoprotein hormones
    • Green ED, Baenziger JU 1988 Asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. II. Distribution of sulphated and sialyated oligosaccharides on bovine, ovine and human pituitary glycoprotein hormones. J Biol Chem 263:36-44
    • (1988) J Biol Chem , vol.263 , pp. 36-44
    • Green, E.D.1    Baenziger, J.U.2
  • 43
    • 0026585325 scopus 로고
    • Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulphation of bovine lutropin oligosaccharides
    • Baenziger JU, Kumar S, Brodbeck M, Smith PL, Beranek MC 1992 Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulphation of bovine lutropin oligosaccharides. Proc Natl Acad Sci USA 89:334-338
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 334-338
    • Baenziger, J.U.1    Kumar, S.2    Brodbeck, M.3    Smith, P.L.4    Beranek, M.C.5
  • 45
    • 0027517557 scopus 로고
    • Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: The role of sialylation and sulfation in TSH bioactivity
    • Szkudlinski MW, Thotakura NR, Bucci I, Joshi LR, Tsai A, East-Palmer J, Shiloach J, Weintraub BD 1993 Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity. Endocrinology 133:1490-1503
    • (1993) Endocrinology , vol.133 , pp. 1490-1503
    • Szkudlinski, M.W.1    Thotakura, N.R.2    Bucci, I.3    Joshi, L.R.4    Tsai, A.5    East-Palmer, J.6    Shiloach, J.7    Weintraub, B.D.8
  • 47
    • 0024447839 scopus 로고
    • Thyroid-stimulating hormone (TSH) deficiency caused by a single base substitution in the CAGYC region of the β-subunit
    • Hayashizaki K, Hiraoka Y, Endo Y, Miyai K, Matsubara K 1989 Thyroid-stimulating hormone (TSH) deficiency caused by a single base substitution in the CAGYC region of the β-subunit. EMBO J 8:2291-2296
    • (1989) EMBO J , vol.8 , pp. 2291-2296
    • Hayashizaki, K.1    Hiraoka, Y.2    Endo, Y.3    Miyai, K.4    Matsubara, K.5
  • 48
    • 0025356512 scopus 로고
    • Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone β-subunit gene
    • Dacou VC, Feltquate DM, Drakopoulou M, Kourides IA, Dracopoli NC 1990 Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone β-subunit gene. Am J Hum Genet 46:988-993
    • (1990) Am J Hum Genet , vol.46 , pp. 988-993
    • Dacou, V.C.1    Feltquate, D.M.2    Drakopoulou, M.3    Kourides, I.A.4    Dracopoli, N.C.5
  • 50
    • 0026335545 scopus 로고
    • Hypogonadism caused by a single amino acid substitution in the β subunit of luteinizing hormone
    • Weiss J, Axelrod L, Whitcomb RW, Harris PE, Crowley WF, Jameson JL 1992 Hypogonadism caused by a single amino acid substitution in the β subunit of luteinizing hormone. N Engl J Med 326: 179-183
    • (1992) N Engl J Med , vol.326 , pp. 179-183
    • Weiss, J.1    Axelrod, L.2    Whitcomb, R.W.3    Harris, P.E.4    Crowley, W.F.5    Jameson, J.L.6
  • 51
    • 0008469328 scopus 로고
    • Elevated serum bioactive LH concentrations in women with PCO
    • Lobo RA, Kletzky OA, DiZerega GS 1982 Elevated serum bioactive LH concentrations in women with PCO. Fertil Steril 37:301-302
    • (1982) Fertil Steril , vol.37 , pp. 301-302
    • Lobo, R.A.1    Kletzky, O.A.2    DiZerega, G.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.