Anti-arthritic activity of hydroalcoholic extract of flowers of moringa oleifera lam. in wistar rats

Journal of Herbs, Spices and Medicinal Plants

Volumn 15, Issue 2, 2009, Pages 149-163

  Mahajan, Shailaja G ^a   Mehta, Anita A ^a  

^a L M COLLEGE OF PHARMACY   (India)

Author keywords

Adjuvant; Cytokines; Inflammation; Medicinal plant

Indexed keywords

ALCOHOL; ANTIRHEUMATIC AGENT; DEXAMETHASONE; FLAVONOID; INTERLEUKIN 1; MORINGA OLEIFERA EXTRACT; PLANT MEDICINAL PRODUCT; POLYPHENOL; RHEUMATOID FACTOR; TANNIN DERIVATIVE; TERPENOID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; WATER;

ALCOHOL; DICOTYLEDON; DISEASE TREATMENT; FLOWER; HISTOPATHOLOGY; MEDICINAL PLANT; OSTEOLOGY; PLANT EXTRACT; RODENT; SERUM; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG ISOLATION; FEMALE; FLOWER; HISTOPATHOLOGY; LYMPHOCYTIC INFILTRATION; MALE; MORINGA OLEIFERA; NONHUMAN; PAW EDEMA; RAT;

ANIMALIA; ARMORACIA RUSTICANA; MORINGA; MORINGA OLEIFERA; MORINGACEAE; RATTUS NORVEGICUS;

EID: 75149174183     PISSN: 10496475     EISSN: 15403580     Source Type: Journal    
DOI: 10.1080/10496470903139363     Document Type: Article

References (52)

1. Arend, W. P., and J. M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor-a in rheumatoid arthritis. Arthritis Rheum. 38(2):151-160.
2. Arner, E. C., and M. A. Pratta. 1989. Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture. Arthritis Rheum. 32(3):288-297.
3. Bertazzolo, N., L. Punzi, M. Stefani, G. Cesaro, M. Pianon, B. Finco, et al. 1994. Interrelationships between interleukin IL-1, IL-6 and IL-8 in SF of various arthropathies. Inflamm. Res. 41(1-2):90-92.
4. Bertolini, D. R., G. E. Nedwin, T. S. Bringman, D. D. Smith, and G. R. Mundy. 1986. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319(6053):516-518.
5. Caceres, A., A. Saravia, S. Rizzo, L. Zabala, E. D. Leon, and F. Nave. 1992. Pharmacologic properties of Moringa oleifera: 2. Screening for antispasmodic, anti-inflammatory and diuretic activity. J. Ethnopharmacol. 36(3): 233-237.
6. Caceres, A., O. Cebreva, O. Morales, P. Miollined, and P. Mendia. 1991. Pharmacological properties of M. oleifera: 1. Preliminary screening for antimicrobial activity. J. Ethnopharmacol. 33(3):213-216.
7. Chuang, P. H., C. W. Lee, J. Y. Chou, M. Murugan, B. J. Shieh, and H. M. Chen. 2007. Antifungal activity of crude extracts and essential oil of Moringa oleifera Lam. Biosource Technol. 98(1):232-236.
8. Dahot, M. U., and A. R. Memon. 1985. Nutritive significance of oil extracted from Moringa oleifera seeds. J. Pharm. (Univ. Karachi). 3(2):75-80.
9. Das, B. R., P. A. Kurup, and P. L. Narasimha Rao. 1958. Antibiotic principle from Moringa Pterosperma Part IX. Inhibition of transaminase by isocyanates. Ind. J. Med. Res. 46:75-77.
10. Dayer, J. M., B. Beutler, and A. Cerami. 1985. Cachectinitumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J. Exp. Med. 162(6):2163-2168.
11. Dayrit, F. M., A. D.Alcantara, and I. M. Villasenor. 1990. The antibiotic compound and its deactivation in aqueous solution. Phil. J. Sci. 119:23-26.
12. Evans, C. H., P. D. Robbins, S. C. Ghivizzani, M. C. Wasko, M. M. Tomaino, R. Kang, et al. 2005. Gene transfer to human joints: Progress toward a gene 485 therapy of arthritis. Proc. Natl. Acad. Sci. U.S.A. 102(24):8698-8703.
13. Ezeamuzie, I. C., A. W. Ambakederemo, F. O. Shode, and S. C. Ekwebelem. 1996. Antiinflammatory effects of Moringa oleifera root extract. Int. J. Pharmacogn. 34(3):207-212.
14. Faizi, S., B. S. Siddiqui, R. Saleem, S. Siddiqui, K. Aftab, and A. H.Gilani. 1995. Fully acetylated carbonate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry 38(4):957-963.
15. Guevara, A. P., C. Vargas, H. Sakurai, Y. Fujiwara, K. Hashimoto, T. Maoka, et al. 1999. An antitumor promoter from Moringa oleifera Lam. Mutat. Res. 440(2):181-188.
16. Halliwell, B. 1994. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence? Lancet. 344(8924):721-724.
17. Hirano, T., T. Matsuda, M. Turner, N. Miyasaka, G. Buchan, B. Tang, K. et al. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18(11):1797-1801.
18. Hopkin, S. J., and A. Meager. 1988. Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon. Clin. Exp. Immunol. 73(1): 88-92.
19. Hopkins, S. J. 1990. Cytokines and eicosanoids in rheumatic diseases. Ann. Rheum. Dis. 49(4):207-210.
20. Husby, G., and R. C. Williams. 1988. Synovial localization of tumor necrosis factor in patients with rheumatoid arthritis. J. Autoimmunol. 1(4):363-371.
21. Jadhav, S. L., S. R Sharma, S. C. Pal, S. B. Kasture, and V. S. Kasture. 2000. Chemistry and pharmacology of Moringa oleifera Lam and M.concanensis Nimo. Indian Drugs 37(3):139-144.
22. Kamanl, A., M. Naziroglu, N. Aydilek, and C. Hacievliyagil. 2003. Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem. Funct. 22(1):53-57.
23. Kasama, T., F. Shiozawa, K. Kobayashi, N. Yajima, M. Hanyuda, H.T. Takeuchi, et al. 2001. Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: Critical involvement of the interaction with synovial fibroblasts. Arthritis Rheum. 44(11):2512-2524.
24. Kim, H. J, V. Krenn, G. Steinhauser, and C. Berek. 1999. Plasma cell development in synovial germinal centers patients with rheumatoid and reactive arthritis. J. Immunol. 162(5):3053-3062.
25. Kirtikar, K. R., and B. D. Basu. 1975. Indian Medicinal Plants, 2nd Ed., Vol.1. In D. Dun, B. Singh, and M. P. Singh, eds. M/s Bishen Singh Mahendra Pal Singh, New Cannaught Place, Dehradun, India. pp. 676-683.
26. Koch, A. E., S. L. Kunkel, and R. M. Strieter. 1995. Cytokines in rheumatoid arthritis. J. Invest. Med. 43(1):28-38.
27. Krause, I., G. Valesini, R. Scrivo, and Y. Shoenfeld. 2003. Autoimmune aspects of cytokine and anticytokine therapies. Am. J. Med. 115(5):390-397.
28. Kruithof, E., D. Baeten, L. D. Rycke, B. Vandooren, D. Foell, J. Roth, et al. 2005. Synovial histopathology of psoriatic arthritis, both oligo and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. Arthritis Res. Ther. 7(3):R569-R580.
29. Landrault, N., P. Poucheret, P. Ravel, F. Gasc, G. Cros, and P. L. Teissedre. 2001. Antioxidant capacities and phenolics levels of French wines from different varieties and vintages. J. Agric. Food. Chem. 49(7):3341-3343.
30. Mahajan, S. G, R. G. Mali, and A. A. Mehta. 2007. Effect of Moringa oleifera Lam. seed extract on toluene diisocyanate-induced immune-mediated inflammatory responses in rats. J. Immunotoxicol. 4(2):85-96.
31. Mahajan, S. G, R. G. Mali, and A. A. Mehta. 2007. Protective effect of ethanolic extract of seeds of Moringa oleifera Lam. against inflammation associated with development of arthritis in rats. J. Immunotoxicol. 4:39-47.
32. Mekonnen, Y., and A. Gessesse. 1998. Documentation on the uses of Moringa stenopetala and its possible antileishmanial and antifertility effects. SINET: Ethiopian J. Sci. 21(2):287-295.
33. Memon, G. M., and L. M. Khatri. 1987. Isolation and spectroscopic studies of mono-palmitic, di-oleic triglyceride from seeds of Moringa oleifera Lam. Pak. J. Sci. Indian Res. 30(5):393-395.
34. Miossec, P. 1992. Cytokine abnormalities in inflammatory arthritis. Baillieres Clin. Rheumatol. 6(2):373-391.
35. Murakami, A, Y. Kitazono, S. Jiwajinda, K. Koshimizu, and H. Ohigashi. 1998. Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor promoter- induced Epstein-Barr virus activation. Planta Med. 64(4):319-323.
36. Njoku, O. U., and M. U. Adikwu. 1997. Investigation on some physicochemical antioxidant and toxicological properties of Moringa oleifera seed oil. Acta Pharm. Zagr. 47(4):287-290.
37. Paech, D., and M. V. Tracey. 1955. Modern Methods of Plant Analysis, Vol.IV. Springer-Verlag, Berlin. pp. 373-374.
38. Pari, L., and N. A. Kumar. 2002. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J. Med. Food 5(3):171-177.
39. Pearson, C. M. 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc. Soc. Exp. Biol. Med. 91(1):95-101.
40. Pearson, C. M., and F. Wood. 1963. Studies of arthritis and other lesions induced in rats by the injection of Mycobacterium adjuvant. Am. J. Pathol. 42(1):93-95.
41. Plant, M. J., A. L. Williams, M. M. O'Sullivan, P. A. Lewis, E. C. Coles, and J. D. Jessop. 2000. Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis. Arthritis Rheum. 43(7):1473-1477.
42. Ramprasath, V. R, P. Shanthi, and P. Sachdanandam. 2006. Curative effect of Semecarpus anacardium Linn. nut milk extract against adjuvant arthritis-with special reference to bone metabolism. Chem. Biol. Interact. 160(3):183-192.
43. Romas, E., M. T. Gillespie, and T. J. Martin. 2002. Involvement of receptor activator of NFkB ligand and tumor necrosis factor-in bone destruction in rheumatoid arthritis. Bone 30(2):340-346.
44. Sarban, S., A. Kocyigit, M. Yazar, and U. E. Isikan. 2005. Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis. Clin. Biochem. 38(11):981-986.
45. Schorlemmer, H. U., R. Kurrle, R. Schleyerbach, and R. R. Bartlett. 1999. Disease modifying activity of malononinitrilamides, derivates of leflunomide's active metabolite, on models of rheumatoid arthritis. Inflamm. Res. 48(2):113-114.
46. Sugarman, B. J., B. B. Aggarwal, P. E. Hass, I. S. Figari, M. A. Palladino, and H. M. Shepard. 1985. Recombinant human tumor necrosis factor-a: Effects on proliferation of normal and transformed cells in vitro. Science 230(4728): 943-945.
47. Udupa, S. L., A. L. Udupa, and D. R. Kulkarni. 1994. Studies on the antiinflammatory and wound healing properties of Moringa oleifera and Aegle marmelos. Fitoterapia 65(2):119-123.
48. Vilcek, J., V. J. Palombella, D. Henriksen-DeStefano, C. Swenson, R. Feinman, M. Hirai, et al. 1986. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J. Exp. Med. 163(3):632-643.
49. Villasenor, I. M., C. Y. Lim-Sylianco, and F. Dayrit. 1989. Mutagens from roasted seeds of Moringa oleifera. Mutat. Res. 224(2):209-212.
50. Walz, D. T., J. J. Dimartino, and A. Misher. 1971. Adjuvant-induced arthritis in rats: Drug effect on physiologic, biochemical and immunologic parameters. J. Pharm. Exp. Ther. 178(1):223-231.
51. Westergren, A. 1926. The techniques of the red cell sedimentation reaction. Am. Rev. Tuberc. 14:94-101.
52. Winter, C. A., E. A. Risley, and W. Nuss. 1962. Carrageenan induced edema in hind paw of rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111:544-547.