Effects of intravenous antidepressant drugs on the excitability of human motor cortex: a study with paired magnetic stimulation on depressed patients

Brain Stimulation

Volumn 3, Issue 1, 2010, Pages 15-21

  Minelli, Alessandra ^a   Bortolomasi, Marco ^b   Scassellati, Catia ^a   Salvoro, Beatrice ^b   Avesani, Mirko ^c   Manganotti, Paolo ^c  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b Casa di Cura Villa S Chiara   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

citalopram; clomipramine; depression; motor cortex excitability; transcranial magnetic stimulation

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; PLACEBO; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; EVOKED MUSCLE RESPONSE; FACILITATION; FEEDBACK SYSTEM; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; MOTOR CORTEX; MOTOR UNIT POTENTIAL; NERVE CELL INHIBITION; NERVE EXCITABILITY; PRIORITY JOURNAL; REST; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; DEPRESSIVE DISORDER, MAJOR; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; PHYSIOLOGY; PROCEDURES;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; CITALOPRAM; CLOMIPRAMINE; DEPRESSIVE DISORDER, MAJOR; EVOKED POTENTIALS, MOTOR; HUMANS; INJECTIONS, INTRAVENOUS; MOTOR CORTEX; PLACEBOS; SEROTONIN UPTAKE INHIBITORS; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 75149165962     PISSN: 1935861X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brs.2009.04.003     Document Type: Article

References (45)

1. Tardito D., Perez J., Tiraboschi E., et al. Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 58 (2006) 115-134
2. Rossini P.M., and Rossi S. Transcranial magnetic stimulation: diagnostic, therapeutic, and research potential. Neurology 68 (2007) 484-488
3. Caramia M.D., Cicinelli P., Paradiso C., et al. Excitability changes of muscular responses to magnetic brain stimulation in patients with central motor disorders. Electroencephalogr Clin Neurophysiol 81 (1991) 243-250
4. Inghilleri M., Berardelli A., Marchetti P., et al. Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation in humans. Exp Brain Res 109 (1996) 467-472
5. Ziemann U., Lonnecker S., Steinhoff B.J., et al. Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 40 (1996) 367-378
6. Manganotti P., Bortolomasi M., Zanette G., et al. Intravenous clomipramine decreases excitability of human motor cortex: a study with paired magnetic stimulation. J Neurol Sci 184 (2001) 27-32
7. Ilic T.V., Korchounov A., and Ziemann U. Complex modulation of human motor cortex excitability by the specific serotonin re-uptake inhibitor sertraline. Neurosci Lett 319 (2002) 116-120
8. Eichhammer P., Langguth B., and Wiegand R. Allelic variation in the serononin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI). Psychopharmacology 49 (2003) 881-883
9. Robol E., Fiaschi A., and Manganotti P. Effects of citalopram on the excitability of the human motor cortex: a paired magnetic stimulation study. J Neurol Sci 221 (2004) 41-46
10. Gerdelat-Mas A., Loubinoux I., Tombari D., et al. Chronic administration of selective serotonin reuptake inhibitor (SSRI) paroxetine modulates human motor cortex excitability in healthy subjects. Neuroimage 27 (2005) 314-322
11. Münchau A., Langosch J.M., Gerschlager W., et al. Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depression. J Neurol Neurosurg Neuropsychiatry 76 (2005) 527-533
12. Reis J., John D., Heimeroth A., et al. Modulation of human motor cortex excitability by single doses of amantadine. Neuropsychopharmacology 31 (2006) 2758-2766
13. Langguth B., Eichhammer P., Spranz C., et al. Modulation of human motor cortex excitability by quetiapine. Psychopharmacology (Berl) 196 (2008) 623-629
14. Solinas C., Lee Y.C., and Reutens D.C. Effect of levetirecetam on cortical excitability: a transcranial magnetic stimulation study. Eur J Neurol 15 (2008) 501-505
15. Mavroudakis N., Caroyer J.M., Brunko E., et al. Effects of diphenylhydantoin on motor potentials evoked with magnetic stimulation. Electroencephalogr Clin Neurophysiol 93 (1994) 428-433
16. Manganotti P., Bongiovanni L.G., Zanette G., et al. Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation. Epilepsia 40 (1999) 316-321
17. Boroojerdi B., Battaglia F., Muellbacher W., et al. Mechanisms influencing stimulus-response properties of the human corticospinal system. Clin Neurophysiol 112 (2001) 931-937
18. Ziemann U., Lonnecker S., Steinhoff B.J., et al. The effects of lorazepam on the motor cortical excitability in man. Exp Brain Res 109 (1996) 127-135
19. Di Lazzaro V., Oliviero A., Meglio M., et al. Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clin Neurophysiol 111 (2000) 794-799
20. Di Lazzaro V., Oliviero A., Saturno E., et al. Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans. J Physiol 564 (2005) 661-668
21. Di Lazzaro V., Pilato F., Dileone M., et al. Dissociated effects of diazepam and lorazepam on short latency afferent inhibition. J Physiol 569 (2005) 315-323
22. Liepert J., Schwenkreis P., Tegenthoff M., et al. The glutamate antagonist riluzole suppresses intracortical facilitation. J Neural Transm 104 (1997) 1207-1214
23. Ziemann U., Tergau F., Bruns D., et al. Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs. Electroencephalogr Clin Neurophysiol 105 (1997) 430-437
24. Koran L.M., Sallee F.R., and Pallanti S. Rapid benefit of intravenous pulse loading of clomipramine in obsessive-compulsive disorder. Am J Psychiatry 154 (1997) 396-401
25. Fallon B.A., Liebowitz M.R., Campeas R., et al. Intravenous clorimipramine for obsessive compulsive disorder refractory to oral clorimipramine. Arch Gen Psychiatry 55 (1998) 918-924
26. Mathew S.J., Coplan J.D., Perko K.A., et al. Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder. Depress Anxiety 14 (2001) 199-208
27. Fountoulakis K.N., Iacovides A., and St Kaprinis G. Combined oral venlafaxine and intravenous clomipramine-A: successful temporary response in a patient with extremely refractory depression. Can J Psychiatry 49 (2004) 73-74
28. Hyttel J., Arnt J., and Sanchez C. The pharmacology of citalopram. Rev Contemp Pharmacother 6 (1995) 271-285
29. Stahl S.M. Using secondary binding properties to select a not so selective serotonin reuptake inhyibitor. J Clin Psychiatry 154 (1998) 668-673
30. Noble S., and Benfield P. Citalopram: a review of its pharmacology, clinical efficacy and tolerability in the treatment of depression. CNS Drugs 8 (1997) 410-432
31. Keller M.B. Citalopram therapy for depression: a review of 10 years of European experience and data from U.S. clinical trials. J Clin Psychiatry 61 (2000) 896-908
32. Kasper S., and Muller-Spahn F. Intravenous antidepressant treatment: focus on citalopram. Eur Arch Psychiatry Clin Neurosc 252 (2002) 105-109
33. Montgomery S.A., and Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 134 (1979) 382-389
34. Rossini P.M., Barker A.T., Berardelli A., et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91 (1994) 79-92
35. Kujirai T., Caramia M.D., Rothwell J.C., et al. Cortico-cortical inhibition in human motor cortex. J Physiol (Lond) 471 (1993) 501-519
36. Ziemann U., Lonnecker S., and Paulus W. Inhibition of human motor cortex by ethanol: a transcranial magnetic stimulation study. Brain 118 (1995) 1437-1446
37. Siebner H.R., and Rothwell J. Transcranial magnetic stimulation: new insights into representational cortical plasticity. Exp Brain Res 148 (2003) 1-16
38. Chen R. Interactions between inhibitory and evcitatory circuits in the human motor cortex. Exp Brain Res 154 (2004) 1-10
39. Manganotti P., Zanette G., Bonato C., et al. Crossed and direct effects of digital nerves stimulation on motor evoked potential: a study with magnetic brain stimulation. Electroencephalogr Clin Neurophysiol 105 (1997) 280-289
40. Triggs W.J., Macdonell R.A., Cros D., et al. Motor inhibition and excitation are independent effects of magnetic cortical stimulation. Ann Neurol 32 (1992) 345-351
41. Bezchlibnyk-Butler K., Aleksic I., and Kennedy S.H. Citalopram-a review of pharmacological and clinical effects. J Psychiatry Neurosci 25 (2000) 241-254
42. Werhahn K.J., Kunesch E., Noachtar S., et al. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans. J Physiol 517 (1999) 591-597
43. Baldessarini R.J. Current status of antidepressants: clinical pharmacology and therapy. J Clin Psychiatry 50 (1989) 117-126
44. Baldessarini R.J. Treatment of depression by altering monoamine metabolism: precursors and metabolic inhibitors. Psychopharmacol Bull 20 (1984) 224-239
45. Kupfer D.J., Spiker D.G., Coble P.A., et al. Sleep and treatment prediction in endogenous depression. Am J Psychiatry 138 (1981) 429-434