Plasma membrane expression of gonadotropin-releasing hormone receptors: Regulation by peptide and nonpeptide antagonists

Molecular Endocrinology

Volumn 24, Issue 2, 2010, Pages 423-435

  Finch, Ann R ^a   Caunt, Christopher J ^a   Armstrong, Stephen P ^a   McArdle, Craig A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

[2 [5 [2 (2 AXABICYCLO[2.2.2]OCT 2 YL) 1,1 DIMETHYL 2 OXOETHYL] 2 (3,5 DIMETHYLPHENYL) 1H INDOL 3 YL] N (2 PYRIDIN 4 YLETHYL)PROPAN 1 AMINE]; BUSERELIN; CETRORELIX; G PROTEIN COUPLED RECEPTOR; GONADORELIN; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; HEMAGGLUTININ; ITURELIX; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BUSERELIN; CELL LINE, TUMOR; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADOTROPHS; GONADOTROPIN-RELEASING HORMONE; HELA CELLS; HORMONE ANTAGONISTS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INDOLES; LIGANDS; MICE; MICROSCOPY, FLUORESCENCE; OLIGOPEPTIDES; PEPTIDES; PROTEIN TRANSPORT; PYRIDINES; RECEPTORS, LHRH; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY;

ADENOVIRIDAE;

EID: 75149152956     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0343     Document Type: Article

References (40)

1. Conn PM, Huckle WR, Andrews WV, McArdle CA 1987 The molecular mechanism of action of gonadotropin releasing hormone (GnRH) in the pituitary. Recent Prog Horm Res 43:29-68
2. Stojilkovic SS, Catt KJ 1995 Expression and signal transduction pathways of gonadotropin-releasing hormone receptors. Recent Prog Horm Res 50:161-205
3. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR 2004 Gonadotropin-releasing hormone receptors. Endocr Rev 25:235-275
4. Cheng CK, Leung PC 2005 Molecular biology of gonadotropin- releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans. Endocr Rev 26:283-306
5. Rispoli LA, Nett TM 2005 Pituitary gonadotropin-releasing hormone receptor: structure, distribution and regulation of expression. Anim Reprod Sci 88:57-74
6. Pierce KL, Premont RT, Lefkowitz RJ 2002 Seven transmembrane receptors. Nat Rev Mol Cell Biol 3:639-650
7. Luttrell LM, Lefkowitz RJ 2002 The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 115:455-465
8. Davidson JS, Wakefield IK, Millar RP 1994 Absence of rapid desensitization of the mouse gonadotropin-releasing hormone receptor. Biochem J 300:299-302
9. McArdle CA, Forrest-Owen W, Willars G, Davidson J, Poch A, Kratzmeier M 1995 Desensitization of gonadotropin-releasing hormone action in the gonadotrope-derived α T3-1 cell line. Endocrinology 136:4864-4871
10. 2+ mobilization. J Biol Chem 271:23711-23717
11. Heding A, Vrecl M, Bogerd J, McGregor A, Sellar R, Taylor PL, Eidne KA 1998 Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics. J Biol Chem 273:11472-11477
12. McArdle CA, Franklin J, Green L, Hislop JN 2002 Signaling, cycling and desensitization of gonadotrophin-releasing hormone receptors. J Endocrinol 173:1-11
13. Hislop JN, Everest HM, Flynn A, Harding T, Uney JB, Troskie BE, Millar RP, McArdle CA 2001 Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling. J Biol Chem 276:39685-39694
14. Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM 2004 Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic 5:821-837
15. Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA 2007 G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacol Rev 59:225-250
16. Davidson JS, Flanagan CA, Zhou W, Becker II, Elario R, Emeran W, Sealfon SC, Millar RP 1995 Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding. Mol Cell Endocrinol 107:241-245
17. Lin X, Janovick JA, Brothers S, Blömenrohr M, Bogerd J, Conn PM 1998 Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Mol Endocrinol 12:161-171
18. Blomenröhr M, Heding A, Sellar R, Leurs R, Bogerd J, Eidne KA, Willars GB 1999 Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization. Mol Pharmacol 56:1229-1237
19. Pawson AJ, Katz A, Sun YM, Lopes J, Illing N, Millar RP, Davidson JS 1998 Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail. J Endocrinol 156:R9-R12
20. Kopito RR, Ron D 2000 Conformational disease. Nat Cell Biol 2:E207-E209
21. Bernier V, Lagacé M, Bichet DG, Bouvier M 2004 Pharmacological chaperones: potential treatment for conformational diseases. Trends Endocrinol Metab 15:222-228
22. Petaja-Repo UE, Hogue M, Laperriere A, Walker P, Bouvier M 2000 Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human δ opioid receptor. J Biol Chem 275:13727-13736
23. Petäjä-Repo UE, Hogue M, Bhalla S, Laperrière A, Morello JP, Bouvier M 2002 Ligands act as pharmacological chaperones and increase the efficiency of δ opioid receptor maturation. EMBO J 21:1628-1637
24. Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE 2004 Membrane trafficking of G-protein coupled receptors. Annu Rev Pharmacol Toxicol 44:559-609
25. Conn PM, Knollman PE, Brothers SP, Janovick JA 2006 Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a g protein-coupled receptor. Mol Endocrinol 20:3035-3041
26. Sedgley KR, Finch AR, Caunt CJ, McArdle CA 2006 Intracellular gonadotropin-releasing hormone receptors in breast cancer and gonadotrope lineage cells. J Endocrinol 191:625-636
27. Finch AR, Sedgley KR, Caunt CJ, McArdle CA 2008 Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines. J Endocrinol 196:353-367
28. Finch AR, Caunt CJ, Armstrong SP, McArdle CA 2009 Agonist-induced internalization and down-regulation of gonadotropin releasing hormone receptors. Am J Physiol Cell Physiol 291:C591-C600
29. Myburgh DB, Millar RP, Hapgood JP 1998 Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization. Biochem J 331:893-896
30. Macian F 2005 NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 84:488-499
31. Zhang X, Bao L, Guan JS 2006 Role of delivery and trafficking of δ-opioid peptide receptors in opioid analgesia and tolerance. Trends Pharmacol Sci 27:324-329
32. Emons G, Müller V, Ortmann O, Schulz KD 1998 Effects of LHRH analogues on mitogenic signal transduction in cancer cells. J Steroid Biochem Mol Biol 65:199-206
33. Schally AV, Halmos G, Rekasi Z, Arencibia-Jiminez JM 2001 The actions of luteinizing hormone-releasing hormone agonists, antagonists and cytotoxic analogues on the luteinizing hormone-releasing hormone receptors on the pituitary and tumors. Infertil Reprod Med Clin North Am 12:17-44
34. Blithe DL 2001 Applications for GnRH antagonists. Trends Endocrinol Metab 12:238-240
35. Heitman LH, Ye K, Oosterom J, Ijzerman AP 2008 Amiloride derivatives and a nonpeptide antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol 73:1808-1815
36. Betz SF, Zhu YF, Chen C, Struthers RS 2008 Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem 26:3331-3348
37. Kohout TA, Xie Q, Reijmers S, Finn KJ, Guo Z, Zhu YF, Struthers RS 2007 Trapping of a nonpeptide ligand by the extracellular domains of the gonadotropin-releasing hormone receptor results in insurmountable antagonism. Mol Pharmacol 72:238-247
38. Caunt CJ, Hislop JN, Kelly E, Matharu AL, Green LD, Sedgley KR, Finch AR, McArdle CA 2004 Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signaling and evidence for multiple active conformations. Endocrinology 145:3594-3602
39. Maudsley S, Davidson L, Pawson AJ, Chan R, López de Maturana R, Millar RP 2004 Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Gαi-coupling state of the type I GnRH receptor. Cancer Res 64:7533-7544
40. López de Maturana R, Pawson AJ, Lu ZL, Davidson L, Maudsley S, Morgan K, Langdon SP, Millar RP 2008 Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling. Mol Endocrinol 22:1711-1722