Complement profile in childhood immune thrombocytopenic purpura: A prospective pilot study

Annals of Hematology

Volumn 84, Issue 12, 2005, Pages 812-815

  Ohali, Meli ^a,b   Maizlish, Yair ^c   Abramov, Haya ^c   Schlesinger, Menachem ^a,b   Bransky, David ^c   Lugassy, Gilles ^b  

^a BARZILAI MEDICAL CENTER   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Complement; Thrombocytopenia

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C9; COMPLEMENT FACTOR H; PROPERDIN;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; COMPLEMENT SYSTEM; CONTROLLED STUDY; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; PATHOGENESIS; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPLENECTOMY;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COMPLEMENT SYSTEM PROTEINS; FEMALE; HUMANS; MALE; PROSPECTIVE STUDIES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; VIRUS DISEASES;

EID: 29444455924     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-005-1085-6     Document Type: Article

References (14)

1. Walker RW, Walker W (1984) Idiopathic thrombocytopenia, initial illness and long term follow up. Arch Dis Child 59:316-322 6721556
2. Zaki H, Hassaneim AA, Khalil AF (1990) Childhood idiopathic thrombocytopenic purpura: Report of 60 cases from Kuwait. J Trop Pediatr 36:10-13 2313774
3. Ben-Yehuda D, Gillis S, Eldor A (1994) Clinical and therapeutic experience in 712 Israeli patients with idiopathic thrombocytopenic purpura. Israeli ITP Study Group. Acta Hematol 91:1-6
4. Kurata Y, Harashi S, Aochi H, Nagamine K, Oshida M, Mizutani H, Tomiyama Y, Tsubakio T, Yonezawa T, Tarui S (1987) Analysis of antigen involved in circulating immune complexes in patient with idiopathic thrombocytopenic purpura. Clin Exp Immunol 67:293-299 3608226
5. Lorhuma AZ, Riccmi H, Masson PL (1977) The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura. Clin Exp Immunol 28:49-55 558848
6. Trent RJ, Clancy RL, Danis V, Basten A (1980) Immune complexes in thrombocytopenic patients: Cause or effect? Br J Haematol 44:645-654 7189663
7. Mancini G, Carbonara AD, Heremans JF (1965) Immunochemical quantitation of antigen by single radial immunodiffusion. Immunochemistry 2:235-254 10.1016/0019-2791(65)90004-2
8. Schlesinger M, Borman I, Lugassy G (1996) The complement system is defective in chronic lymphatic leukemia patients and in their healthy relatives. Leukemia 10:1509-1513 8751471
9. Keifel V, Speath P, Muheller-Eckhardt C (1986) Immune thrombocytopenic purpura: Autoimmune or immune complex disease? Br J Haematol 64:57-68 2944539
10. Nielsen HE, Truedson L, Donner M (1994) Partial complement deficiencies in idiopathic thrombocytopenia of childhood. Acta Pediatr 83:749-753
11. Hed J (1998) Role of complement in immune/idiopathic thrombocytopenic purpura. Acta Pediatr Suppl 424:37-40 10.1080/080352598750030726
12. Jurg AS, Yun CN, Peters DK (1986) The role of complement and its receptors in the elimination of immune complexes. N Engl J Med 315:488-495 2942776
13. Schifferli JA, Peters DK (1983) Complement, the immune-complex lattice, and the pathophysiology of complement-deficiency syndrome. Lancet 2:957-959 10.1016/S0140-6736(83)90464-6
14. Schifferli JA (1987) The classical pathway of complement prevents the formation of insoluble antigen-antibody complexes: Biological implications. Immunol Lett 14:225-228 10.1016/0165-2478(87)90105-2