Is cardiac surgery sufficient to create insufficiency?*

Pediatric Critical Care Medicine

Volumn 11, Issue 1, 2010, Pages 150-151

  Bronicki, Ronald A ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

Adrenal insufficiency; Cardiopulmonary bypass; Corticosteroids; Glucocorticoids; Hemodynamic instability; Systemic inflammatory response

Indexed keywords

ALDOSTERONE; CATECHOLAMINE; CORTICOTROPIN; CYTOKINE; GLUCOCORTICOID; HYDROCORTISONE;

ADAPTATION; ADRENAL INSUFFICIENCY; ARTERY RESISTANCE; BLOOD VESSEL TONE; CARDIOPULMONARY BYPASS; CARDIOVASCULAR FUNCTION; CLINICAL EVALUATION; CORTICOTROPIN TEST; CRITICAL ILLNESS; CYTOKINE PRODUCTION; EDITORIAL; GENOMICS; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART SURGERY; HEMODYNAMICS; HOMEOSTASIS; HORMONE SYNTHESIS; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; ISCHEMIA; MORTALITY; OXYGENATION; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY; SCIENTIFIC LITERATURE; SEPSIS; STRESS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 75149136626     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181ae4cc4     Document Type: Editorial

References (15)

1. Wehling M: Specific, nongenomic actions of steroid hormones. Annu Rev Physiol 1997; 59:365-393
2. Lamberts S, Bruining HA, DeJong FH: Corticosteroid therapy in severe illness. N Engl J Med 1997; 337:1285-1292
3. Jaattela M, Ilvesmaki V, Voutilainen R, et al.: Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 1991; 128:623-629
4. Gaillard RC, Turnill D, Sappino P, et al.: Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 1990; 127:101-106
5. Sasidharan P: Role of corticosteroids in neonatal blood pressure homeostasis. Clin Perinatol 1998; 25:723-738
6. Annane D, Sebille V, Charpentier C, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-871
7. Sibbald WJ, Short A, Cohen MP, et al.: Variations in adrenocortical responsiveness during severe bacterial infections: Unrecognized adrenocortical insufficiency in severe bacterial infections. Ann Surg 1977; 186:29-33
8. Riordan FA, Thomson A, Ratcliffe JM, et al.: Admission cortisol and adrenocorticotrophic hormone levels in children with meningococcal disease: Evidence of adrenal insufficiency? Crit Care Med 1999; 27:2257-2261
9. Pizarro CF, Troster EJ, Damiani D, et al.: Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med 2005; 33:855-859
10. Ng PC, Lee CH, Bnur FL, et al.: A doubleblind, randomized, controlled study of a "stress dose" of hydrocortisone for rescue treatment of refractory hypotension in preterm infants. Pediatrics 2006; 117:367-375
11. Kopelman AE, Moise AA, Holbert D, et al.: A single very early dexamethasone dose improves respiratory and cardiovascular adaptation in preterm infants. J Pediatr 1999; 135:345-350
12. Fernandez E, Schrader R, Watterberg K: Prevalence of low cortisol values in term and near-term infants with vasopressorresistant hypotension. J Perinatol 2005; 25: 114-118
13. Menon K, Lawson M: Identification of adrenal insufficiency in pediatric critical illness. Pediatr Crit Care Med 2007; 8:276-278
14. Gajarski RJ, Stefanelli CB, Graziano JN, et al.: Adrenocortical response in infants undergoing cardiac surgery with cardiopulmonary bypass and circulatory arrest. Pediatr Crit Care Med 2010; 11:44-51
15. Bronicki RA, Backer CL, Baden HP, et al.: Dexamethasone reduced the inflammatory resposne to cardiopulmonary bypass in children. Ann Thorac Surg 2000; 69:1490-1495