No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression

Psychiatric Genetics

Volumn 20, Issue 1, 2010, Pages 8-13

  Chipman, Phillip ^a   Jorm, Anthony F ^c   Tan, Xiao Yan ^b   Easteal, Simon ^b  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b Biology and Environment   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Anxiety; Depression; Gene environment interactions; Serotonin 1A receptor single nucleotide polymorphism

Indexed keywords

SEROTONIN 1A RECEPTOR;

ADULT; ANXIETY; ARTICLE; CAUCASIAN; CLINICAL ASSESSMENT; COHORT ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; ENVIRONMENTAL STRESS; FEMALE; GENE; GENE INTERACTION; GROUPS BY AGE; HEALTH SURVEY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; PERSONALITY; PRIORITY JOURNAL; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM;

ADULT; ANXIETY; CHILD; COHORT STUDIES; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RECEPTOR, SEROTONIN, 5-HT1A; SOCIAL ENVIRONMENT; STRESS, PSYCHOLOGICAL; TIME FACTORS; YOUNG ADULT;

EID: 75149123951     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e3283351140     Document Type: Article

References (50)

1. Arias B, Arranz MJ, Gasto C, Catalan R, Pintor L, Gutierrez B, et al. (2002). Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT1A receptor gene as putative risk factors in major depression. Mol Psychiatry 7:930-932.
2. Artigas F, Romero L, De Montigny C, Blier P (1996). Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci 19:378-383. (Pubitemid 26270513)
3. Artigas F, Celada P, Laruelle M, Adell A (2001). How does pindolol improve antidepressant action? Trends Pharmacol Sci 22:224-228.
4. Australian Bureau of Statistics (ABS) (2008). National Survey of Mental Health and Wellbeing: Summary of Results, 2007 (cat. no. 4326.0). Canberra.
5. Barnes NM, Sharp T (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
6. Bowen DM, Najlerahim A, Procter AW, Francis PT, Murphy E (1989). Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proc Natl Acad Sci USA 86:9504-9508.
7. Brugha T, Bebbington P, Tennant C, Hurry J (1985). The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 15:189-194.
8. Carver CS, White TL (1994). Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. J Pers Soc Psychol 67:319-333.
9. Celada P, Puig MV, Casanovas JM, Guillazo G, Artigas F (2001). Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABAA, and glutamate receptors. J Neurosci 21:9917-9929.
10. Cervo L, Grignaschi G, Samanin R (1988). 8-Hydroxy-2-(di-n-propylamino)- tetralin, a selective serotonin1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis. Eur J Pharmacol 158:53-59.
11. Cohen J (1988). Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale NJ: Lawrence Erlbaum Associates, Inc.
12. Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR (2006). Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci 26:1864-1871.
13. David SP, Murthy NV, Rabiner EA, Munafo MR, Johnstone EC, Jacob R, et al. (2005). A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25:2586-2590.
14. Dawson LA, Nguyen HQ, Smith DL, Schecter LE (2002). Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex. J Psychopharmacol 16:145.
15. De Vry J (1995). 5-HT1A receptor agonists: recent developments and controversial issues. Psychopharmacology (Berl) 121:1-26.
16. Drevets WC, Frank E, Price JC, Kupfer DJ, Greer PJ, Mathis C (2000). Serotonin type-1A receptor imaging in depression. Nucl Med Biol 27:499-507.
17. Eysenck SBG, Eysenck HJ, Barrett P (1985). A revised version of the psychoticism scale. Pers Individ Diff 6:21-29.
18. Feighner JP, Boyer WF (1989). Serotonin-1A anxiolytics: an overview. Psychopathology 22 (Suppl 1):21-26.
19. File SE (1996). Recent developments in anxiety, stress, and depression. Pharmacol Biochem Behav 54:3-12.
20. File SE, Gonzalez LE (1996). Anxiolytic effects in the plus maze of 5-HT1Areceptor ligands in dorsal raphe and ventral hippocampus. Pharmacol Biochem Behav 54:123-128.
21. Garriock HA, Delgado P, Kling MA, Carpenter LC, Burke M, Burke WJ, et al. (2006). Number of risk genotypes is a risk factor for major depressive disorder: a case control study. Behav Brain Funct 2:24.
22. Goldberg D, Bridges K, Duncan-Jones P, Grayson D (1988). Detecting anxiety and depression in general medical settings. Br Med J 297:897-899.
23. Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby K, et al. (2002). Serotonin1A receptor acts during development to establish normal anxietylike behaviour in the adult. Nature 416:396-400.
24. Hajó s M, Hajó s-Korcsok E, Sharp T (1999). Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. Br J Pharmacol 126:1741-1750.
25. Heisler LK, Chu HM, Brennan TJ, Danao JA, Bajwa P, Parsons LH, et al. (1998). Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci U S A 95:15049-15054.
26. Holm SA (1979). A simple sequentially rejective multiple test procedure. Scand J Statistics 6:65-70.
27. Huang YY, Battistuzzi C, Oquendo MA, Harkavy-Friedman J, Greenhill L, Zalsman G, et al. (2004). Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 7:441-451.
28. Jorm AF, Korten AE, Christensen H, Jacomb PA, Rodgers B, Parslow RA (2003). Association of obesity with anxiety, depression, and emotional well being: a community survey. Aust NZ J Public Health 27:434-440.
29. Jorm AF,Windsor TD, Dear KBG, Anstey KJ, Christensen H, Rodgers B (2005). Age group differences in psychological distress: the role of psychosocial risk factors that vary with age. Psychol Med 35:1253-1263.
30. Koller G, Bondy B, Preuss UW, Zill P, Soyka M (2006). The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Behav Brain Funct 2:7.
31. Kostowski W, P?aznik A, Stefanski R (1989). Intra-hippocampal buspirone in animal models of anxiety. Eur J Pharmacol 168:393-396.
32. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, et al. (2003). Impaired repression at a 5-Hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23:8788-8799.
33. Lemonde S, Du L, Bakish D, Hrdina P, Albert PR (2004). Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol 7:501-506.
34. Ló pez JF, Chalmers DT, Little KY, Watson SJ (1998). Regulation of serotonin1A glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression. Biol Psychiatry 43:547-573.
35. Menard J, Treit D (1999). Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev 23:591-613.
36. Parks CL, Robinson PS, Sibille E, Shenk T, Toth M (1998). Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A 95:10734-10739.
37. Pazos A, Palacios JM (1985). Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I: serotonin-1 receptors. Brain Res 346:205-230. (Pubitemid 16241111)
38. Pineyro G, Blier P (1999). Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533-591.
39. Ramboz S, Oosting R, Amara DA, Kung HF, Blier P, Mendelsohn M, et al. (1998). Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci U S A 95:14476-14481.
40. Rosenman S, Rodgers B (2004). Childhood adversity in an Australian population. Soc Psychiatry Psychiatr Epidemiol 39:695-702.
41. Rothe C, Gutknecht L, Freitag C, Tauber R, Mö ssner R, Franke P, et al. (2004). Association of a functional-1019C >G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int J Neuropsychopharmacol 7:189-192. (Pubitemid 38823287)
42. Schreiber R, De Vry J (1993). Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT, ipsapirone and buspirone in the rat. Eur J Pharmacol 249:341-351. (Pubitemid 23334109)
43. Serretti A, Artioli P, Lorenzi C, Pirovano A, Tubazio V, Zanardi R (2004). The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. Int J Neuropsychopharmacol 7:453-460.
44. Sprouse JS, Aghajanian GK (1987). Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1:3-9.
45. Strobel A, Gutknecht L, Rothe C, Reif A, Mö ssner R, Zeng Y, et al. (2003). Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110:1445-1453.
46. Vergé D, Daval G, Patey A, Gozlan H, El Mestikawy S, Hamon M (1985). Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur J Pharmacol 113:463-464.
47. Vergé D, Daval G, Marcinkiewicz M, Patey A, El Mestikawy S, Gozlan H, et al. (1986). Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J Neurosci 6:3474-3482.
48. Wasserman D, Geijer T, Sokolowski M, Vsevolod Rozanov V, Wasserman J (2006). The serotonin 1A receptor C (-1019) G polymorphism in relation to suicide attempt. Behav Brain Funct 2:14.
49. Watson D, Clark LA, Tellegen A (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54:1063-1070.
50. Wu S, Comings DE (1999). A common C-1018G polymorphism in the human 5-HT1A receptor gene. Psychiatr Genet 9:105-106.