Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells

Marine Drugs

Volumn 7, Issue 4, 2009, Pages 589-599

  Oda, Taiko ^a   Lee, Jong Soo ^b,e   Sato, Yuta ^a   Kabe, Yasuaki ^c   Sakamoto, Satoshi ^c   Handa, Hiroshi ^c   Mangindaan, Remy E P ^d   Namikoshi, Michio ^b  

^a KEIO UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d SAM RATULANGI UNIVERSITY   (Indonesia)

^e Gyeongsang National University   (South Korea)

Author keywords

LPS; N,N didesmethylgrossularine 1; Natural product; NF B; Raw 264.7 cells; TNF

Indexed keywords

ANTIINFLAMMATORY AGENT; CD14 ANTIGEN; CYTOKINE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; N,N DIDESMETHYLGROSSULARINE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCIDIACEA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; INFLAMMATORY DISEASE; LONG TERM CARE; NONHUMAN; POLYCARPA AURATA; RHEUMATOID ARTHRITIS;

ASCIDIA; MURINAE; POLYCARPA;

EID: 75149118321     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md7040589     Document Type: Article

References (18)

1. Ross, J.A.; Auger, M.J.; Burke, B.; Lewis, C.E. The biology of the macrophage. In The Macrophage, 2nd ed.; Burke, B., Lewis, C.E., Eds.; Oxford Medical Publications: Oxford, UK, 2002; pp. 1-72.
2. Poltorak, A.; He, X.; Smirnova, I.; Liu, M.Y.; van Huffel, C.; De, X.; Bridwell, D.; Alejos, E.; Silva, M.; Galanos, C.; Freudenberg, M.; Ricciardi-Castagnoli, P.; Layton, B.; Beatler, B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998, 282, 2085-2088.
3. Mendes, S.D.S.; Candi, A.; Vansteenbrugge, M.; Pignon, M.-R.; Bult, H.; Boudjeltia, K.Z.B.; Munaut, C.; Taes, M. Microarray analysis of the effects of NF-κB or p13K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells Synaergistic effects of rapamycin on LPS-induced MMP9-overexpression. Cell Signaling 2009, 21, 1109-1122
4. + monocyte-lineage cells from the bone marrow of theumatoid arthritis patients. Arthritis Rheum. 1996, 39, 836-843.
5. Abas, S.A.; Hossain, M.B.; Helm, D.; Schmits, F.J.; Laney, M.; Cabusly, R.; Schatzman, R.C. Alkaloids from the Tunicate Polycarpa aurata from Chuuk Atoll. J. Org. Chem. 1996, 61, 2709-2712.
6. Miyake, F. Y.; Yakushijin, K.; Horne, D.A. Biomimetic synthesis of grossularines-1. Angew. Chem. Int. Ed. 2005, 44, 3280-3282.
7. Moquin-Pattey, C.; Guyot, M. Grossularine-1 and grossularine-2, cytotoxic α-carbolines from the tunicate: Dendrodoa grossularia. Tetrahedron 1989, 45, 3445-3450.
8. Helbecque, N.; Moquin, C.; Bernier, J.L.; Morel, E.; Guyot, M.; Henichart, J.P. Grossularine-1 and grossularine-2, α-carbolines from Dendrodoa grossularia, as possible intercalative agents. Cancer Biochem. Biophys. 1987, 9, 271-279.
9. Wang, W.-F.; Oda, T.; Fujita, A.; Mangindaan, R.E.P.; Nakazawa, T.; Ukai, K.; Kobayashi, H.; Namikoshi, M. Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata. Tetrahedron 2007, 63, 409-412.
10. Keifer, A.J.; Guttridge, C.D.; Ashburner, P.B.; Baldwin, S.A. Inhibition of NF-kappaB activity by thalidomide through suppression of IkappaB kinase activity. J. Biol. Chem. 2001, 276, 22382-22387.
11. Nagahira, A.; Nagahira, K.; Murafuji, H.; Abe, K.; Magota, K.; Matsui, M.; Oikawa, S. Identification of a novel inhibitor of LPS-Induced TNF-α production with antiproliferative activity in monocyte/macrophages. Biochem. Biophys. Res. Commun. 2001, 281, 1030-1036.
12. Bresnihan, B.; Youssef, P.; Burke, B.; Lewin, G.E. Macrophages in rheumatoid arthritis. In The Macrkophage, 2nd ed.; Burke, B., Lewis, C.E., Eds.; Oxford Medical Publications: Oxford, UK, 2002; pp. 391-433.
13. Coussens, L.M.; Werb, Z. Inflammation and cancer. Nature 2002, 420, 860-867.
14. Siebenlist, U.; Brown, K.; Claudio, E. Control of lymphocyte development by nuclear factor-kappaB. Nat. Rev. Immunol. 2005, 5, 435-445.
15. Oda, T.; Ueda, A.; Shimizu, N.; Handa, H.; Kasahara, T. Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: Effect of alprazolam on c-Re/p65 and c-Rel/p50 bindin g to the monocyte chemoattractant protein 1 promoter region. J. Immunol. 2002, 169, 3329-3335.
16. Shimizu, S.; Nomoto, M.; Naito, S.; Yamamoto, T.; Momose, K. Stimulation of nitric oxide synthase during oxidative endothelial cell injury. Biochem Pharmacol. 1998, 55, 77-83.
17. Carmichael, J.; DeGraff, W.G.; Gazdar, A.F.; Gazdar, A.F.; Minna, J.D.; Mitchell, J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity. Cancer Res. 1987, 47, 939-942.
18. Rojanasakul, Y.; Ye, J.; Chen, F.; Wang, L.; Cheng, N.; Castranova, V.; Vallyathan, V.; Shi, X. Dependence of NF-kappaB activation and free radical generation on silica-induced TNF-alpha production in macrophages. Mol. Cell. Biochem. 1999, 200, 119-125.