P53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells

International Journal of Hematology

Volumn 91, Issue 1, 2010, Pages 69-77

  Ikezoe, Takayuki ^a   Yang, Jing ^a   Nishioka, Chie ^a,b   Yokoyama, Akihito ^a  

^a KOCHI UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

AML; Apoptosis; Aurora B kinase; AZD1152 HQPA; Bax; P53

Indexed keywords

2 [[3 [4 [5 [2 (3 FLUOROANILINO) 2 OXOETHYL] 1H PYRAZOL 3 YLAMINO] 7 QUINAZOLINYLOXY]PROPYL](ETHYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE; AURORA B KINASE; AURORA KINASE INHIBITOR; AZD1152 HQPA; CASPASE; LIPOCORTIN 5; PROTEIN BAX; PROTEIN NOXA; PROTEIN P53; PROTEIN P73; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE; CELL CYCLE ARREST; CELL GROWTH; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; GROWTH DISORDER; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; POLYPLOIDY; PROTEIN BINDING; PROTEIN TARGETING; UPREGULATION;

APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 75049084994     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0462-7     Document Type: Article

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