Methylentetrahydrofolate reductase and nitric oxide synthase polymorphism in patients with atherosclerosis and diabetes

Pathology and Oncology Research

Volumn 15, Issue 4, 2009, Pages 631-637

  Szabó, Gábor Viktor ^a   Kunstár, Alíz ^b   Acsády, György ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Atherosclerosis; Cardiovascular Risk; Methylentetrahydrofolate reductase; Nitric oxide synthase; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ASPARTIC ACID; GLUTAMIC ACID; GUANINE; NITRIC OXIDE SYNTHASE; THYMINE;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE; GENOTYPE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; NOS 3 GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

ALLELES; ATHEROSCLEROSIS; CASE-CONTROL STUDIES; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC;

EID: 75049084847     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-009-9163-z     Document Type: Article

References (25)

1. R Ross 1993 The pathogenesis of atherosclerosis: a perspective for the 1990s Nature 362 801 809 10.1038/362801a0 1:CAS:528:DyaK3sXktVGqu7c%3D 8479518 (Pubitemid 23132154)
2. E Boerwinkle DL Elsworth DM Hallman A Biddinger 1996 Genetic analysis of atherosclerosis: a research paradigm for the common disease Hum Mol Genet 5 1405 1410 1:CAS:528:DyaK28XlsFyltb0%3D 8875244 (Pubitemid 26293900)
3. C Pallaud C Sass F Zannad G Siest S Visvikis 2001 APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort) Clin Genet 59 316 324 10.1034/j.1399-0004.2001.590504.x 1:STN:280:DC%2BD3MzmsFOhuw%3D%3D 11359462 (Pubitemid 32451969)
4. P Jerrard-Dunne HS Markus DA Steckel A Buehler S von Kegler M Sitzer 2003 Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies Arterioscler Thromb Vasc Biol 23 302 306 10.1161/01.ATV.0000051383.75507.60 1:CAS:528:DC%2BD3sXptFyrsQ%3D%3D 12588775 (Pubitemid 36231944)
5. J Davignon P Ganz 2004 Role of endothelial dysfunction in atherosclerosis Circulation 109 27 32 10.1161/01.CIR.0000115644.35804.8B
6. MG Colombo U Paradossi MG Andreassi N Botto S Manfredi S Masetti A Biagini A Clerico 2003 Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease Clin Chem 49 389 395 10.1373/49.3.389 1:CAS:528:DC%2BD3sXhvFSks7s%3D 12600950 (Pubitemid 36250199)
7. N Jeerooburkhan LC Jones S Bujac JA Cooper GJ Miller P Vallance SE Humphries AD Hingorani 2001 Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease Hypertension 38 1054 1061 10.1161/hy1101.092967 1:CAS:528:DC%2BD3MXovVOrsLY%3D 11711497
8. AS Marroni IF Metzger DC Souza-Costa S Nagassaki VC Sandrim RX Correa F Rios-Santos JE Tanus-Santos 2005 Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms Nitric Oxide 12 177 182 10.1016/j.niox.2005.02.002 1:CAS:528:DC%2BD2MXivVejtrk%3D 15797845 (Pubitemid 40432137)
9. JE Tanus-Santos M Desai DA Flockhart 2001 Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants Pharmacogenetics 11 719 725 10.1097/00008571-200111000-00011 1:CAS:528:DC%2BD38XnsFKru78%3D 11692081 (Pubitemid 33078242)
10. Juan P Casas Leonelo E Bautista Steve E Humphries Aroon D Hingorani 2004 Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease Circulation 09 1359 1365 10.1161/01.CIR.0000121357.76910.A3 (Pubitemid 38387821)
11. A Mazza D Giugliano C Motti C Cortese F Andreotti G Marra A Nulli 2000 Glycemia, MTHFR genotype and low homocysteine in uncomplicated type 2 diabetic patients Atherosclerosis 149 223 224 10.1016/S0021-9150(99)00421-9 1:CAS:528:DC%2BD3cXitVGhtLY%3D 10799016 (Pubitemid 30125995)
12. J Selhub PF Jacques AG Bostom D Agostino RB PW Wilson AJ Belanger O Leary DH PA Wolf EJ Schaefer IH Rosenberg 1995 Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis N Engl J Med 332 286 291 10.1056/NEJM199502023320502 1:STN:280:DyaK2M7hsFOitw%3D%3D 7816063
13. H Refsum PM Ueland O Nygard SE Vollset 1998 Homocysteine and cardiovascular disease Ann Rev Med 49 31 62 10.1146/annurev.med.49.1.31 1:CAS:528:DyaK1cXhtFKrur8%3D 9509248 (Pubitemid 28197439)
14. 1,2 American J Clin Nutr 72 324 332 1:CAS:528:DC%2BD3cXlsFyhsbc%3D
15. H Refsum PM Ueland O Nygard SE Vollset 1998 Homocysteine and cardiovascular disease Ann Rev Med 49 31 62 10.1146/annurev.med.49.1.31 1:CAS:528:DyaK1cXhtFKrur8%3D 9509248 (Pubitemid 28197439)
16. I Bova J Chapman C Sylantiev AD Korczyn NM Bornstein 1999 The A677V methylenetetrahydrofolate reductase gene polymorphism and carotid atherosclerosis Stroke 30 2180 2182 1:CAS:528:DyaK1MXntFynu70%3D 10512925
17. C Pallaud C Sass F Zannad G Siest S Visvikis 2001 APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort) Clin Genet 59 316 324 10.1034/j.1399-0004.2001.590504.x 1:STN:280:DC%2BD3MzmsFOhuw%3D%3D 11359462 (Pubitemid 32451969)
18. A Passaro A Vanini F Calzoni L Alberti PF Zamboni R Fellin A Solini 2001 Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women Atherosclerosis 157 175 180 10.1016/S0021- 9150(00)00696-1 1:CAS:528:DC%2BD3MXksVGku7s%3D 11427218 (Pubitemid 32539368)
19. N Inamoto T Katsuya Y Kokubo T Mannami T Asai S Baba J Ogata H Tomoike T Ogihara 2003 Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population Stroke 34 1628 1633 10.1161/01.STR.0000075769.09092. 82 1:CAS:528:DC%2BD3sXkvFyjtbw%3D 12775885 (Pubitemid 36842615)
20. G Zuliani S Volpato P Mecocci A Cherubini 2000 The A677V MTHFR allele is not associated with carotid atherosclerosis in octogenarians Stroke 31 990 991 1:STN:280:DC%2BD3c3hvFGqtw%3D%3D 10754009
21. A Mazza C Motti A Nulli G Marra A Gnasso A Pastore G Federici C Cortese 2000 Lack of association between carotid intima-media thickness and methylenetetrahydrofolate reductase gene polymorphism or serum homocysteine in non-insulin-dependent diabetes mellitus Metabolism 1949 718 723 10.1053/meta.2000.6254
22. GP Rossi M Cesari M Zanchetta S Colonna G Maiolino L Pedon M Cavallin P Maiolino AC Pessina 2003 The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study J Am Coll Cardiol 41 930 937 10.1016/S0735-1097(02)03012-7 1:CAS:528:DC%2BD3sXislejsLw%3D 12651036 (Pubitemid 36315532)
23. R Alvarez P Gonzalez A Batalla JR Reguero G Iglesias-Cubero S Hevia A Cortina E Merino I Gonzalez V Alvarez E Coto 2001 Association between the NOS3 (-786T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease Nitric Oxide 5 343 348 10.1006/niox.2001.0351 1:CAS:528:DC%2BD3MXls1egt7g%3D 11485372 (Pubitemid 32735386)
24. H Cai DE Wilcken XL Wang 1999 The Glu-298-> Asp (894G-> T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease J Mol Med 77 511 514 10.1007/s001099900020 1:CAS:528:DyaK1MXmtVSlsL0%3D 10475066 (Pubitemid 29372583)
25. K Hibi T Ishigami K Tamura S Mizushima N Nyui T Fujita H Ochiai M Kosuge Y Watanabe Y Yoshii M Kihara K Kimura M Ishii S Umemura 1998 Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction Hypertension 32 521 526 1:CAS:528:DyaK1cXmtlyjsLw%3D 9740620