Antigenic structure of the human muscle nicotinic acetylcholine receptor main immunogenic region

Journal of Molecular Neuroscience

Volumn 40, Issue 1-2, 2010, Pages 217-220

  Luo, Jie ^a   Lindstrom, Jon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Acetylcholine binding protein; Experimental autoimmune myasthenia gravis; Main immunogenic region; Monoclonal antibodies; Myasthenia gravis; Nicotinic acetylcholine receptor

Indexed keywords

AUTOANTIBODY; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; EPITOPE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ALPHA CHAIN; ANTIGEN STRUCTURE; ANTIGENICITY; APLYSIA; CHIMERA; CONFERENCE PAPER; CRYSTAL STRUCTURE; HUMAN; HUMAN TISSUE; IMMUNOGENICITY; MYASTHENIA GRAVIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; RECEPTOR BINDING;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; AUTOANTIBODIES; EPITOPES; FEMALE; HUMANS; MUSCLE, SKELETAL; MYASTHENIA GRAVIS; NEUROMUSCULAR JUNCTION; OOCYTES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECEPTORS, NICOTINIC; RECOMBINANT FUSION PROTEINS; XENOPUS LAEVIS;

ANIMALIA; APLYSIA;

EID: 75049083167     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9271-y     Document Type: Conference Paper

References (19)

1. EX Albuquerque EF Pereira M Alkondon SW Rogers 2009 Mammalian nicotinic acetylcholine receptors: From structure to function Physiological Reviews 89 73 120 10.1152/physrev.00015.2008 1:CAS:528:DC%2BD1MXit1Cqtrw%3D 19126755
2. AG Amit RA Mariuzza SE Phillips RJ Poljak 1985 Three-dimensional structure of an antigen-antibody complex at 6 Å resolution Nature 313 156 158 10.1038/313156a0 1:CAS:528:DyaL2MXns12ktg%3D%3D 3965976 (Pubitemid 15192346)
3. R Beroukhim N Unwin 1995 Three-dimensional location of the main immunogenic region of the acetylcholine receptor Neuron 15 323 331 10.1016/0896-6273(95)90037-3 1:CAS:528:DyaK2MXnvVWlsbg%3D 7544140
4. K Brejc WJ van Dijk RV Klaassen, et al. 2001 Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors Nature 411 269 276 10.1038/35077011 1:CAS:528:DC%2BD3MXjvF2qsbc%3D 11357122 (Pubitemid 32467026)
5. M Castillo J Mulet M Aldea, et al. 2009 Role of the N-terminal α-helix in biogenesis of α7 nicotinic receptors Journal of Neurochemistry 108 1399 1409 10.1111/j.1471-4159.2009.05924.x 1:CAS:528:DC%2BD1MXjsFWgsL8%3D 19166504
6. B Conti-Tronconi S Tzartos J Lindstrom 1981 Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor Biochemistry 20 2181 2191 10.1021/bi00511a017 1:CAS:528:DyaL3MXhvFSjtLw%3D 6786327 (Pubitemid 11088722)
7. BM Conti-Fine M Milani HJ Kaminski 2006 Myasthenia gravis: Past, present, and future Journal of Clinical Investigation 116 2843 2854 10.1172/JCI29894 1:CAS:528:DC%2BD28XhtFyrsLnE 17080188 (Pubitemid 44684466)
8. CD Dellisanti Y Yao JC Stroud ZZ Wang L Chen 2007 Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution Nature Neuroscience 10 953 962 10.1038/nn1942 1:CAS:528:DC%2BD2sXotFykurc%3D 17643119 (Pubitemid 47185209)
9. SB Hansen G Sulzenbacher T Huxford P Marchot P Taylor Y Bourne 2005 Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations EMBO Journal 24 3635 3646 10.1038/sj.emboj.7600828 1:CAS:528:DC%2BD2MXhtFaht7vF 16193063 (Pubitemid 41509370)
10. M Konstantakaki SJ Tzartos K Poulas E Eliopoulos 2007 Molecular modeling of the complex between Torpedo acetylcholine receptor and anti-MIR Fab198 Biochemical and Biophysical Research Communications 356 569 575 10.1016/j.bbrc.2007.02.161 1:CAS:528:DC%2BD2sXjvFOnur4%3D 17376405 (Pubitemid 46499003)
11. A Kuryatov J Onksen J Lindstrom 2008 Roles of accessory subunits in α4β2nicotinic receptors Molecular Pharmacology 74 132 143 10.1124/mol.108.046789 1:CAS:528:DC%2BD1cXot1aksb0%3D 18381563 (Pubitemid 351872165)
12. JM Lindstrom 2000 Acetylcholine receptors and myasthenia Muscle and Nerve 23 453 477 10.1002/(SICI)1097-4598(200004)23:4<453::AID-MUS3>3.0.CO;2-O 1:CAS:528:DC%2BD3cXisFSlt7Y%3D 10716755 (Pubitemid 30164770)
13. J Lindstrom J Luo A Kuryatov 2008 Myasthenia gravis and the tops and bottoms of AChRs: Antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains Annals of the New York Academy of Sciences 1132 29 41 10.1196/annals.1405.007 1:CAS:528:DC%2BD1cXoslSlu7o%3D 18567851 (Pubitemid 351841350)
14. JP Merlie R Sebbane S Gardner E Olson J Lindstrom 1983 The regulation of acetylcholine receptor expression in mammalian muscle Cold Spring Harbor Symposia on Quantitative Biology 48 135 146 1:CAS:528:DyaL2cXktFOnsr4%3D 6586356
15. NS Millar 2008 RIC-3: A nicotinic acetylcholine receptor chaperone British Journal of Pharmacology 153 S177 S183 10.1038/sj.bjp.0707661 1:CAS:528:DC%2BD1cXislSjurw%3D 18246096 (Pubitemid 351341014)
16. SJ Tzartos JM Lindstrom 1980 Monoclonal antibodies used to probe acetylcholine receptor structure: Localization of the main immunogenic region and detection of similarities between subunits Proceedings of the National Academy of Sciences of the United States of America 77 755 759 10.1073/pnas.77.2.755 1:CAS:528:DyaL3cXhslyqsr4%3D 6153804
17. SJ Tzartos ME Seybold JM Lindstrom 1982 Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies Proceedings of the National Academy of Sciences of the United States of America 79 188 192 10.1073/pnas.79.1.188 1:STN:280: DyaL387gsF2rsw%3D%3D 6948300
18. SJ Tzartos T Barkas MT Cung, et al. 1998 Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptor Immunological Reviews 163 89 120 10.1111/j.1600-065X. 1998.tb01190.x 1:CAS:528:DyaK1cXlsVert7g%3D 9700504 (Pubitemid 28327864)
19. F Wang ME Nelson A Kuryatov, et al. 1998 Chronic nicotine treatment up-regulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells Journal of Biological Chemistry 273 28721 28732 10.1074/jbc.273.44.28721 1:CAS:528:DyaK1cXntlaitbc%3D 9786868 (Pubitemid 28507559)