Increased O-linked β-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats

Critical Care Medicine

Volumn 38, Issue 2, 2010, Pages 562-571

  Nöt, Laszlo G ^a,d   Brocks, Charlye A ^b   Vámhidy, Laszlo ^d   Marchase, Richard B ^a   Chatham, John C ^a,b,c  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Glucosamine; Hexosamine biosynthesis pathway; Hypovolemic shock; Multiple organ dysfunction syndrome; O GlcNAc; PUGNAc

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBAMIC ACID DERIVATIVE; DNA; GLUCOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MANNITOL; N ACETYLGLUCOSAMINE; O (2 ACETAMIDO 2 DEOXYGLUCOPYRANOSYLIDENE)AMINO N PHENYLCARBAMATE; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLEEDING; CONTROLLED STUDY; FOLLOW UP; HYPOVOLEMIC SHOCK; INFLAMMATION; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RESUSCITATION; SURVIVAL;

EID: 74949122920     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181cb10b3     Document Type: Article

References (40)

1. Chatham JC, Not LG, Fulop N, et al: Hex-osamine biosynthesis and protein O-glycosyl-ation: The first line of defense against stress, ischemia, and trauma. Shock 2008; 29: 431-440
2. Mizock BA: Alterations in fuel metabolism in critical illness: Hyperglycaemia. Best Pract Res Clin Endocrinol Metab 2001; 15: 533-551
3. Jarhult J: Osmotic fluid transfer from tissue to blood during hemorrhagic hypotension. Acta Physiol Scand 1973; 89:213-226
4. Ware J, Ljungqvist O, Norberg KA, et al: Osmolar changes in haemorrhage: The effects of an altered nutritional status. Acta Chir Scand 1982; 148:641-646
5. Nettelbladt CG, Alibergovic A, Ljungqvist O: Pre-stress carbohydrate solution prevents fatal outcome after hemorrhage in 24-hour food-deprived rats. Nutrition 1996; 12: 696-699
6. Atiyeh BS, Gunn SW, Dibo SA: metabolic implications of severe burn injuries and their management: A systematic review of the literature. World J Surg 2008
7. Finney SJ, Zekveld C, Elia A, et al: Glucose control and mortality in critically ill patients. JAMA 2003; 290:2041-2047
8. Laczy B, Hill BG, Wang K, et al: Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system. Am J Physiol Heart Circ Physiol 2009; 296:H13-H28
9. Comer FI, Hart GW: O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate. J Biol Chem 2000; 275:29179-29182
10. Not LG, Marchase RB, Fulop N, et al: Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats. Shock 2007; 28: 345-352
11. Zou L, Yang S, Hu S, et al: The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels. Shock 2007; 27:402-408
12. Yang S, Zou LY, Bounelis P, et al: Glucosamine administration during resuscitation improves organ function after trauma hemorrhage. Shock 2006; 25:600-607
13. Macias CA, Kameneva MV, Tenhunen JJ, et al: Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera. Shock 2004; 22:151-156
14. Hauptman JG, DeJong GK, Blasko KA, et al: Measurement of hepatocellular function, cardiac output, effective blood volume, and oxygen saturation in rats. Am J Physiol 1989; 257:R439-R444
15. Nagy T, Champattanachai V, Marchase RB, et al: Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. Am J Physiol Cell Physiol 2006; 290:C57-C65
16. Salgame P, Varadhachary AS, Primiano LL, et al: An ELISA for detection of apoptosis. Nucleic Acids Res 1997; 25:680-681
17. Trautwein C, Rakemann T, Brenner DA, et al: Concanavalin A-induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroen-terology 1998; 114:1035-1045
18. Zhu X, Zhao H, Graveline AR, et al: MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 2006; 291: H1900-H1909
19. Szalay L, Shimizu T, Suzuki T, et al: Andro-stenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis. Am J Physiol Gas-trointest Liver Physiol 2006; 291: G260-G266
20. Lee AS: The ER chaperone and signaling regulator GRP78/BiP as a monitor of endo-plasmic reticulum stress. Methods 2005; 35: 373-381
21. Comer FI, Vosseller K, Wells L, et al: Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine. Anal Biochem 2001; 293:169-177
22. Kneass ZT, Marchase RB. Neutrophils exhibit rapid agonist-induced increases in protein-associated O-GlcNAc. J Biol Chem 2004; 279: 45759-45765
23. Regel G, Grotz M, Weltner T, et al: Pattern of organ failure following severe trauma. World J Surg 1996; 20:422-429
24. Keel M, Trentz O: Pathophysiology of poly-trauma. Injury 2005; 36:691-709
25. Di Paola R, Mazzon E, Muia C, et al: Protective effect of hypericum perforatum in zymo-san-induced multiple organ dysfunction syndrome: Relationship to its inhibitory effect on nitric oxide production and its peroxyni-trite scavenging activity. Nitric Oxide 2007; 16:118-130
26. Xing D, Feng W, Not LG, et al: Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury. Am J Physiol Heart Circ Physiol 2008; 295: H335-H342
27. Zou L, Yang S, Champattanachai V, et al: Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling. Am J Physiol Heart Circ Physiol 2009; 296:H515-H523
28. Fulop N, Zhang Z, Marchase RB, et al: Glu-cosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation. Am J Physiol Heart Circ Physiol 2007; 292:H2227-H2236
29. Champattanachai V, Marchase RB, Chatham JC: Glucosamine protects neonatal cardio-myocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc. Am J Physiol Cell Physiol 2007; 292: C178-C187
30. Jones SP, Zachara NE, Ngoh GA, et al: Car-dioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation 2008; 117:1172-1182
31. Champattanachai V, Marchase RB, Chatham JC: Glucosamine protects neonatal cardio-myocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2. Am J Physiol Cell Physiol 2008; 294:C1509-C1520
32. Liu J, Marchase RB, Chatham JC: Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J Mol Cell Cardiol 2007; 42:177-185
33. O'Donnell N, Zachara NE, Hart GW, et al: Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 2004; 24:1680-1690
34. McClain DA, Lubas WA, Cooksey RC, et al: Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci USA 2002; 99:10695-10699
35. Macauley MS, Whitworth GE, Debowski AW, et al: O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. J Biol Chem 2005; 280:25313-25322
36. Lehrman MA: Teaching dolichol-linked oli-gosaccharides more tricks with alternatives to metabolic radiolabeling. Glycobiology 2007; 17:75R-85R
37. Gurfinkel V, Poggetti RS, Fontes B, et al: Hypertonic saline improves tissue oxygen-ation and reduces systemic and pulmonary inflammatory response caused by hemor-rhagic shock. J Trauma 2003; 54:1137-1145
38. Claridge JA, Schulman AM, Young JS: Improved resuscitation minimizes respiratory dysfunction and blunts interleukin-6 and nuclear factor-kappa B activation after traumatic hemorrhage. Crit Care Med 2002; 30: 1815-1819
39. Kiraly LN, Differding JA, Enomoto TM, et al: Resuscitation with normal saline (NS) vs. lactated ringers (LR) modulates hypercoagu-lability and leads to increased blood loss in an uncontrolled hemorrhagic shock swine model. J Trauma 2006; 61:57-64; discussion, 64-155
40. Todd SR, Malinoski D, Muller PJ, et al: Lac-tated Ringer's is superior to normal saline in the resuscitation of uncontrolled hemor-rhagic shock. J Trauma 2007; 62:636-639