Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis

Experimental Dermatology

Volumn 19, Issue 2, 2010, Pages 148-150

  Zouboulis, Christos C ^a,b   Seltmann, Holger ^a   Alestas, Theodosios ^b  

^a DESSAU MEDICAL CENTER   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Leukotrienes; Lipids; Sebaceous gland; Treatment; Zileuton

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE B4; ZILEUTON;

ARACHIDONIC ACID METABOLISM; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; LETTER; LIPOGENESIS; SEBACEOUS GLAND;

ARACHIDONIC ACID; CELL COUNT; CELL LINE; HUMANS; HYDROXYUREA; INTERLEUKIN-6; INTERLEUKIN-8; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE B4; LIPOGENESIS; SEBACEOUS GLANDS;

EID: 74949118296     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00929.x     Document Type: Letter

References (19)

1. Zouboulis C C. Is acne vulgaris a genuine inflammatory disease? Dermatology 2001, 203:277-279.
2. Zouboulis C C, Eady A, Philpott M. What is the pathogenesis of acne? Exp Dermatol 2005, 14:143-152.
3. Zouboulis C C, Baron J M, Böhm M. Frontiers in sebaceous gland biology and pathology. Exp Dermatol 2008, 17:542-551.
4. Zouboulis C C, Schagen S, Alestas T. The sebocyte culture - a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne. Arch Dermatol Res 2008, 300:397-413.
5. Alestas T, Ganceviciene R, Fimmel S, Müller-Decker K, Zouboulis C C. Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med 2006, 84:75-87.
6. Yokomizo T, Izumi T, Shimizu T. Leukotriene B4: metabolism and signal transduction. Arch Biochem Biophys 2001, 355:231-241.
7. Haeggstrom J Z. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic LTB4 biosynthesis. J Biol Chem 2004, 279:50639-50642.
8. Wróbel A, Seltmann H, Fimmel S. Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol 2003, 120:175-181.
9. Zouboulis C C. Leukotrien-Antagonisten bei atopischen Erkrankungen und Akne. Akt Dermatol 2003, 29:419-425.
10. Carter G W, Young P R, Albert D H. 5-lipoxygenase inhibitory activity of zileuton. J Pharm Exp Ther 1990, 256:929-937.
11. Zouboulis C C, Nestoris S, Adler Y D. A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. Arch Dermatol 2003, 139:668-670.
12. Zouboulis C C, Saborowski A, Boschnakow A. Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production. Dermatology 2005, 210:36-38.
13. Zouboulis C C, Seltmann H, Neitzel H, Orfanos C E. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999, 113:1011-1020.
14. Larsson R, Nygren P. A rapid fluorometric method for semiautomated determination of cytotoxicity and cellular proliferation of human tumor cell lines in microculture. Anticancer Res 1989, 9:1111-1119.
15. Hammarstrom S, Lindgren J A, Marcelo C, Duell E A, Anderson T F, Voorhees J J. Arachidonic acid transformations in normal and psoriatic skin. J Invest Dermatol 1979, 73:180-183.
16. Iversen L, Kragballe K, Ziboh V A. Significance of leukotriene A4 hydrolase in the pathogenesis of psoriasis. Skin Pharmacol 1997, 10:169-177.
17. Ruzicka T, Simmert T, Peskar B A, Ring J. Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. J Invest Dermatol 1986, 86:105-108.
18. Fogh K, Herlin T, Kragballe K. Eicosanoids in skin of patients with atopic dermatitis: Prostaglanin E2 and leukotriene B4 are present in biologically active concentrations. J Allergy Clin Immunol 1989, 83:450-455.
19. Jeremy A H, Holland D B, Roberts S G, Thomson K F, Cunliffe W J. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003, 121:20-27.