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Excess placental soluble Fms-like tyrosine kinase 1 (sFlt-1) may contribute to endothelial dysfunction, hypertension and proteinuria in preeclampsia
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Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor
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AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase
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Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia
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Dechend R, Homuth V, Wallukat G, Muller DN, Krause M, Dudenhausen J, Haller H, Luft FC. Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia. J Soc Gynecol Investig. 2006;13:79-86.
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Antibodies from preeclamptic patients stimulate increased intracellular Ca2 + mobilization through angiotensin receptor activation
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Thway TM, Shlykov SG, Day MC, Sanborn BM, Gilstrap LC III, Xia Y, Kellems RE. Antibodies from preeclamptic patients stimulate increased intracellular Ca2 + mobilization through angiotensin receptor activation. Circulation. 2004;110:1612-1619.
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Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion
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Bobst SM, Day MC, Gilstrap LC III, Xia Y, Kellems RE. Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion. Am J Hypertens. 2005;18:330-336.
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Hypertension in response to autoantibodies to the angiotensin II type i receptor (AT1-AA) in pregnant rats: Role of endothelin-1
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LaMarca B, Parrish M, Ray L, Murphy S, Roberts L, Glover P, Wallukat G, Wenzel K, Cockrell K, Martin JN Jr, Ryan MJ, Dechend R. Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension. 2009;54: 905-909.
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Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
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Zhou CC, Ahmad S, Mi T, Abbasi S, Xia L, Day MC, Ramin SM, Ahmed A, Kellems RE, Xia Y. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension. 2008;51:1010-1019.
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49149112861
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Angiotensin receptor agonistic autanti-bodies induce pre-eclampsia in pregnant mice
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Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autanti-bodies induce pre-eclampsia in pregnant mice. Nat Med. 2008;14: 855-862.
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13
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Soluble fms-like tyrosine-1 (sFlt-1) production is enhanced during hypertension in response to tumor necrosis factor-alpha (TNF-a) and agonistic autoantibodies to the angiotensin II type i receptor (AT1-AA)
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[abstract]. Presented at the October 25-28 Maui, Hawaii
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Parrish MR, Murphy SR, Keiser S, Ray LF, Dechend R, Martin JN, Granger JP, LaMarca B. Soluble fms-like tyrosine-1 (sFlt-1) production is enhanced during hypertension in response to tumor necrosis factor-alpha (TNF-a) and agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) [abstract]. Presented at the Central Association of Obstetricians and Gynecologists Meeting; October 25-28, 2009; Maui, Hawaii.
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(2009)
Central Association of Obstetricians and Gynecologists Meeting
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Parrish, M.R.1
Murphy, S.R.2
Keiser, S.3
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Dechend, R.5
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14
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33744960698
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Relation between circulating angiotensin II type 1 receptor agonistic autoantibodies and soluble fms-like tyrosine kinase 1 in the pathogenesis of preeclampsia
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Stepan H, Faber R, Wessel N, Wallukat G, Schultheiss HP, Walther T. Relation between circulating angiotensin II type 1 receptor agonistic autoantibodies and soluble fms-like tyrosine kinase 1 in the pathogenesis of preeclampsia. J Clin Endocrinol Metab. 2006;91:2424-2427.
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Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: Correlation with disease severity
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Siddiqui AH, Irani RA, Blackwell SC, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity. Hypertension. 2010;55: 386-393.
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Siddiqui, A.H.1
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