Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat

Acta Pharmacologica Sinica

Volumn 30, Issue 12, 2009, Pages 1594-1600

  Wang, Jia Ling ^a,b   Wang, Long ^c   Wu, Zhao Tang ^a   Yuan, Wen Jun ^a   Su, Ding Feng ^a   Ni, Xin ^a   Yan, Jian Jun ^d   Wang, Wei Zhong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Shanghai Research Center for Biomodel Organism   (China)

^d Eastern Institute of Hepatobiliary Surgery   (China)

Author keywords

Centrally acting drug; Extracellular recording; I1 imidazoline receptor; Microinjection; Presympathetic neuron

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; EFAROXAN; IMIDAZOLINE RECEPTOR; MOXONIDINE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG INHIBITION; HEART RATE; HISTOPATHOLOGY; IONTOPHORESIS; KIDNEY NERVE; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NONHUMAN; PRESSORECEPTOR REFLEX; RAT; RECEPTOR AFFINITY; ROSTRAL VENTROLATERAL MEDULLA; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC NERVE CELL; SYMPATHETIC TONE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BAROREFLEX; BENZOFURANS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; IMIDAZOLINE RECEPTORS; IONTOPHORESIS; KIDNEY; MEDULLA OBLONGATA; MICROINJECTIONS; NEURONS; RATS; RATS, INBRED SHR; SYMPATHETIC NERVOUS SYSTEM; SYNAPTIC POTENTIALS; YOHIMBINE;

EID: 74949100112     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.165     Document Type: Article

References (47)

1. Ernsberger P, Damon TH, Graff LM, Schafer SG, Christen MO. Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. J Pharmacol Exp Ther 1993; 264: 172-182
2. Dampney RA. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 1994; 74: 323-364
3. Haxhiu MA, Dreshaj I, Schafer SG, Ernsberger P. Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. J Cardiovasc Pharmacol 1994; 24 Suppl 1: S1-S8.
4. Reis DJ. Neurons and receptors in the rostroventrolateral medulla mediating the antihypertensive actions of drugs acting at imidazoline receptors. J Cardiovasc Pharmacol 1996; 27 Suppl 3: S11-S18.
5. Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P. Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease. J Hum Hypertens 2001; 15 Suppl 1: S57-S60.
6. Johansson M, Gao SA, Friberg P, Annerstedt M, Carlstrom J, Ivarsson T, et al. Baroreflex effectiveness index and baroreflex sensitivity predict all-cause mortality and sudden death in hypertensive patients with chronic renal failure. J Hypertens 2007; 25: 163-168
7. Su DF, Miao CY. Reduction of blood pressure variability: a new strategy for the treatment of hypertension. Trends Pharmacol Sci 2005; 26: 388-390
8. Head GA. Baroreflexes and cardiovascular regulation in hypertension. J Cardiovasc Pharmacol 1995; 26 Suppl 2: S7-16.
9. Harron DW. Antihypertensive drugs and baroreflex sensitivity. Effects of rilmenidine. Am J Med 1989; 87: 57S-62S.
10. Medvedev OS, Kunduzova OR, Murashev AN, Medvedeva NA. Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs. J Auton Nerv Syst 1998; 72: 205-209
11. Mancia G, Ferrari A, Gregorini L, Zanchetti A. Clonidine and carotid baroreflex in essential hypertension. Hypertension 1979; 1: 362-370
12. Head GA, Burke SL, Sannajust FJ. Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits. J Hypertens 2001; 19: 1615-1624
13. Mayorov DN, Burke SL, Head GA. Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits. J Cardiovasc Pharmacol 2001; 37: 252-261
14. Head GA, Burke SL. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. J Hypertens 2000; 18: 1263-1276
15. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 2004; 43: 1042-1047
16. Ma XJ, Shen FM, Liu AJ, Shi KY, Wu YL, Su DF. Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in strokeprone, spontaneously hypertensive rats. Acta Pharmacol Sin 2007; 28: 1550-1558
17. Wang LG, Zeng J, Yuan WJ, Su DF, Wang WZ. Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline-like drugs in anaesthetized rats. Exp Physiol 2007; 92: 849-858
18. Wang WZ, Yuan WJ, Tang CS, Su DF. Electrophysiological evidences for the contribution of NMDA receptors to the inhibition of clonidine on the RVLM presympathetic neurons. Brain Res 2004; 1023: 163-166
19. Brown DL, Guyenet PG. Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ Res 1985; 56: 359-369
20. Lipski J, Kanjhan R, Kruszewska B, Rong W. Properties of presympathetic neurones in the rostral ventrolateral medulla in the rat: an intracellular study "in vivo". J Physiol 1996; 490 ( Pt 3): 729-744
21. Goodchild AK, Dampney RA, Bandler R. A method for evoking physiological responses by stimulation of cell bodies, but not axons of passage, within localized regions of the central nervous system. J Neurosci Methods 1982; 6: 351-363
22. Paxions G WC. The rat brain in stereotaxic coordinates (4th ed). New York: Academic press; 1998.
23. Wang LG, Zeng J, Yuan WJ, Su DF, Wang WZ. Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline-like drugs in anaesthetized rats. Exp Physiol 2007; 92: 849-858
24. Wang WZ, Yuan WJ, Ren AJ, Pan YX, Tang CS, Su DF. Role of I1-imidazoline receptors within the caudal ventrolateral medulla in cardiovascular responses to clonidine in rats. J Cardiovasc Pharmacol 2003; 42: 1-9.
25. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 2004; 43: 1042-1047
26. Harron DW. Antihypertensive drugs and baroreflex sensitivity. Effects of rilmenidine. Am J Med 1989; 87: 57S-62S.
27. Mancia G, Ferrari A, Gregorini L, Zanchetti A. Clonidine and carotid baroreflex in essential hypertension. Hypertension 1979; 1: 362-370
28. Su DF, Miao CY. Reduction of blood pressure variability: a new strategy for the treatment of hypertension. Trends Pharmacol Sci 2005; 26: 388-390
29. Head GA, Burke SL, Sannajust FJ. Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits. J Hypertens 2001; 19: 1615-1624
30. Mayorov DN, Burke SL, Head GA. Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits. J Cardiovasc Pharmacol 2001; 37: 252-261
31. Head GA, Burke SL. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. J Hypertens 2000; 18: 1263-1276
32. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 1989; 14: 177-183
33. Judy WV, Watanabe AM, Henry DP, Besch HR Jr, Murphy WR, Hockel GM. Sympathetic nerve activity: role in regulation of blood pressure in the spontaneously hypertensive rat. Circ Res 1976; 38: 21-29
34. Johansson M, Gao SA, Friberg P, Annerstedt M, Carlstrom J, Ivarsson T, et al. Baroreflex effectiveness index and baroreflex sensitivity predict all-cause mortality and sudden death in hypertensive patients with chronic renal failure. J Hypertens 2007; 25: 163-168
35. La Rovere MT, Pinna GD, Hohnloser SH, Marcus FI, Mortara A, Nohara R, et al. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation 2001; 103: 2072-2077
36. Su DF, Miao CY. Reduction of blood pressure variability: a new strategy for the treatment of hypertension. Trends Pharmacol Sci 2005; 26: 388-390
37. Ernsberger P, Damon TH, Graff LM, Schafer SG, Christen MO. Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. J Pharmacol Exp Ther 1993; 264: 172-182
38. Goldberg MR, Robertson D. Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor. Pharmacol Rev 1983; 35: 143-180
39. Dampney RA. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 1994; 74: 323-364
40. Head GA, Burke SL. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. J Hypertens 2000; 18: 1263-1276
41. Head GA, Burke SL, Sannajust FJ. Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits. J Hypertens 2001; 19: 1615-1624
42. Ma XJ, Shen FM, Liu AJ, Shi KY, Wu YL, Su DF. Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in strokeprone, spontaneously hypertensive rats. Acta Pharmacol Sin 2007; 28: 1550-1558
43. Mancia G, Ferrari A, Gregorini L, Zanchetti A. Clonidine and carotid baroreflex in essential hypertension. Hypertension 1979; 1: 362-370
44. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 2004; 43: 1042-1047
45. Moreira TS, Takakura AC, Menani JV, Colombari E. Involvement of central alpha1- and alpha2-adrenoceptors on cardiovascular responses to moxonidine. Eur J Pharmacol 2007; 563: 164-171
46. Bruban V, Estato V, Schann S, Ehrhardt JD, Monassier L, Renard P, et al. Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation. Circulation 2002; 105: 1116-1121
47. Head GA, Burke SL. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit. J Hypertens 2000; 18: 1263-1276