Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs

Journal of the Autonomic Nervous System

Volumn 72, Issue 2-3, 1998, Pages 205-209

  Medvedev, Oleg S ^a   Kunduzova, Oksana R ^a   Murashev, Arkady N ^b   Medvedeva, Natalya A ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

Antihypertensive treatment; Arterial pressure lability; Barodenervation; Clonidine; Hypertension; Moxonidine; Rats; Rilmenidine

Indexed keywords

CLONIDINE; IMIDAZOLINE DERIVATIVE; MOXONIDINE; RILMENIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTERIAL PRESSURE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR EFFECT; CONFERENCE PAPER; CONTROLLED STUDY; DENERVATION; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; RAT; TELEMETRY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CIRCADIAN RHYTHM; CLONIDINE; DENERVATION; HEART RATE; IMIDAZOLES; INJECTIONS, INTRAVENOUS; MALE; MOTOR ACTIVITY; OXAZOLES; PRESSORECEPTORS; RATS; RATS, WISTAR; SINUS OF VALSALVA; TELEMETRY;

EID: 0031754215     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00106-4     Document Type: Conference Paper

References (24)

1. Abdel-Rahman, A.-R.A., 1989. Reversal by ethanol of the hypertensive effect of clonidine in conscious spontaneously hypertensive rats. Hypertension 14, 531-541.
2. Abdel-Rahman, A.-R.A., 1992. Aortic baroreceptors exert a tonically active restraining influence on centrally mediated depressor responses. J. Cardiovasc. Pharmacol. 19, 233-245.
3. Bishop, V.S., Shade, R.E., Haywood, J.R., Hamm, C., 1987. Sinoaortic denervation in the nonhuman primate. Am. J. Physiol. 252, R294-R298.
4. Bonham, A.C., Trapani, A.J., Portis, L.R., Brody, M.J., 1984. Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine. J. Hypertens. Suppl. 2, S543-S546.
5. Callahan, M.F., da Rocha, M.J.A., Morris, M., 1992. Sinoaortic denervation does not increase cardiovascular/endocrine responses to stress. Neuroendocrinology 56, 735-741.
6. Cowley, A.W., Liard, J.F., Guyton, A.C., 1972. Role of the baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ. Res. 32, 564-576.
7. El-Mas, M.M., Abdel-Rahman, A.A., 1995. Upregulation of imidazoline receptors in the medulla oblongata accounts for the enhanced hypotensive effect of clonidine in aortic barodenervated rats. Brain Research 691, 195-204.
8. El-Mas, M.M., Carroll, R., Abdel-Rahman, A.A., 1994. Centrally mediated reduction in cardiac output elicits the enhanced hypotensive effect of clonidine in conscious aortic barodenervated rats. J. Cardiovasc. Pharmacol. 24, 184-193.
9. Ernsberger, P., Giuliano, R., Willette, R.N., Granata, A.R., Reis, D.J., 1988. Hypotensive action of clonidine analogs correlates with binding affinity at imidazole and not alpha-2 adrenergic receptors in the rostral ventrolateral medulla. J. Hypertens. 6, S554-S557, Suppl. 6.
10. Ernsberger, P., Westbrooks, K.L., Christen, N.O., Schafer, S.G., 1992. A second generation of centrally acting antihypertensive agents act on putative Il-imidazoline receptors. J. Cardiovasc. Pharmacol. 20, S1-810, Suppl. 4.
11. Ernsberger, P., Haxhiu, M.A., Graff, L.M., Collins, L.A., Dreshaj, I., Grove, D.L., Graves, M.E., Schafer, S.G., Christen, M.O., 1994. A novel mechanism of action for hypertension control: moxonidine as a selective I1-imidazoline agonist. Cardiovasc. Drugs Ther. 8, 27-41, Suppl. 1.
12. Guazzi, M., Zanchetti, A., 1965. Blood pressure and heart rate during natural sleep of cat and their regulation by carotid sinus and aortic reflexes. Arch. Ital. Biol. 103, 789-817.
13. Haxhiu, M.A., Dreshaj, I., Schafer, S.G., Ernsberger, P., 1994. Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. J. Cardiovasc. Pharmacol. 24, S1-S8, Suppl. 1.
14. Hayashi, J., Takeda, K., Kuwabara, T., Takesako, T., Itoh, H., Hirata, M., Tanabe, S., Nakata, T., Sasaki, S., Nakagawa, M., 1993. Clonidine improves central attenuation of the baroreflex in spontaneously hypertensive rats. Jpn. Heart J. 34 (3), 333-339.
15. Ito, C.S., Scher, A.M., 1981. Hypertension following arterial baroreceptor denervation in the unanesthetized dog. Circ. Res. 48, 576-586.
16. Julien, C., Zhang, Z.Q., Barres, C., 1993. Role of vasoconstrictor tone in arterial pressure lability after chronic sympathectomy and sinoaortic denervation in rats. J. Auton. Nerv. Syst. 42, 1-10.
17. Krieger, E.M., 1964. Neurogenic hypertension in the rat. Circ. Res. 15, 511-521.
18. Nurminen, M.L., Culman, J., Unger, T., 1997. Moxonidine reduces blood pressure and sympathetic tone in conscious spontaneously hypertensive rats. Fundam. Clin. Pharmacol. 11, 121s, Suppl. 1.
19. Osborn, J.W., England, S.K., 1990. Normalization of arterial pressure after barodenervation: role of pressure natriuresis. Am. J. Physiol. 259 (6), R1172-R1180, Pt 2.
20. Ricci, D., Taira, C.A., Enero, M.A., 1992. Cardiovascular responses of sinoaortic-denervated rats to intracerebroventricular injection of al-and α 2-adrenoreceptor agonists. Eur. J. Pharmacol. 212, 195-200.
21. Sannajust, F., Cerutti, C., Koenig-Berard, E., Sassard, J., 1992. Influence of anesthesia on the cardiovascular effects of rilmenidine and clonidine in spontaneously hypertensive rats. Br. J. Pharmacol. 105, 542-548.
22. Van Zwieten, P.A., 1997. Central imidazoline (I1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine. J. Hypertens. 15, 117-125.
23. Watkins, L., Maixner, W., 1993. Hypotensive effect of clonidine is not mediated by enhanced baroreflex gain in rats. Cardiovasc. Pharmacol. 21 (2), 264-271.
24. Zhang, Z.Q., Barres, C., Julien, C., 1995. Involvement of vasodilator mechanisms in arterial pressure lability after sino-aortic baroreceptor denervation in rat. J. Physiol. London 482, 435-448.