MGMT gene is aberrantly methylated from the early stages of colorectal cancers

Hepato-Gastroenterology

Volumn 56, Issue 96, 2009, Pages 1642-1644

  Hibi, Kenji ^a   Goto, Tetsuhiro ^a   Mizukami, Hiroki ^a   Kitamura, Youhei ^a   Sakata, Makiko ^a   Saito, Mitsuo ^a   Ishibashi, Kazuyoshi ^a   Kigawa, Gaku ^a   Nemoto, Hiroshi ^a   Sanada, Yutaka ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Colorectal cancer; Quantitative methylation specific PCR

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; METHYLATION; POLYMERASE CHAIN REACTION; PRIMARY TUMOR; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

EID: 74949095961     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Bos JL, Fearon ER, Hamilton SR, et al: Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293-297.
2. Nishisho I, Nakamura Y, Miyoshi Y, et al: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991; 253: 665-669.
3. Baker SJ, Markowitz S, Fearon ER, et al: Suppression of human colorectal carcinoma cell growth by wildtype p53. Science 1990; 249: 912-915.
4. Hibi K, Nakamura H, Hirai A, et al: Loss of H19 imprinting in esophageal cancer. Cancer Res 1996; 56: 480-482.
5. Hibi K, Taguchi M, Nakamura H, et al: Alternative splicing of the FHIT gene in colorectal cancer. Jpn J Cancer Res 1997; 88: 385-388.
6. Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-532.
7. 6-methylguanine-DNA methyl-transferase gene MGMT in human normal and tumor tissues. J Natl Cancer Inst 1992; 84:337-340.
8. Herfarth KK, Brent TP, Danam RP, et al: A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers. Mol Carcinogenesis 24; 90-98,1999.
9. Hibi K, Taguchi M, Nakayama H, et al: Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma. Clin Cancer Res 2001; 7: 3135-3138.
10. Greenlee RT, Murray T, Bolden S, et al: Cancer statistics, 2000. CA Cancer J Clin 2000; 50: 7-33.
11. Hibi K, Nakayama H, Kodera Y, et al: CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer. Br J Cancer 2004; 90: 1030-1033.
12. Hibi K, Sakata M, Sakuraba K, et al: Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer. Anticancer Res 2008; 28: 1581-1584.
13. Hibi K, Mizukami H, Shirahata A, et al: Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. Anticancer Res in press.
14. Shirahata A, Sakata M, Sakuraba K, et al: Vimentin methylation as a marker for advanced colorectal carcinoma. Anticancer Res in press.