Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats

Hypertension

Volumn 55, Issue 2, 2010, Pages 474-480

  Padia, Shetal H ^a   Howell, Nancy L ^a   Kemp, Brandon A ^a   Fournie Zaluski, Marie Claude ^b   Roques, Bernard P ^b   Carey, Robert M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b Pharmaleads   (France)

Author keywords

Aminopeptidase N; Angiotensin III; Angiotensin receptors; Hypertension; Natriuresis; SHR

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN II DERIVATIVE; ANGIOTENSIN II TYPE 2; CANDESARTAN; LITHIUM; MICROSOMAL AMINOPEPTIDASE; SODIUM; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; ESSENTIAL HYPERTENSION; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY TUBULE ABSORPTION; NATRIURESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; SODIUM URINE LEVEL;

ANALYSIS OF VARIANCE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIGENS, CD13; BENZIMIDAZOLES; DISEASE MODELS, ANIMAL; FEMALE; GLOMERULAR FILTRATION RATE; HYPERTENSION; IMIDAZOLES; LITHIUM; NATRIURESIS; PROBABILITY; PYRIDINES; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR, ANGIOTENSIN, TYPE 2; SODIUM; TETRAZOLES;

EID: 74949094651     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.109.144956     Document Type: Conference Paper

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