A new mechanism of phosphoregulation in signal transduction pathways

Science Signaling

Volumn 2, Issue 96, 2009, Pages

  Jung, Kirsten ^a   Jung, Heinrich ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARGININE KINASE; ASPARTIC ACID; CREATINE PHOSPHATE; HEAT SHOCK PROTEIN; HISTIDINE; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEIC ACID BINDING PROTEIN; PROTEIN KINASE; SERINE; THREONINE; TYROSINE; BACTERIAL PROTEIN; MCSB PROTEIN, BACILLUS SUBTILIS;

BACILLUS SUBTILIS; CLOSTRIDIUM; COLLISIONALLY ACTIVATED DISSOCIATION; ENZYME ACTIVITY; EUKARYOTE; GENE EXPRESSION; GEOBACILLUS; GLUCONEOGENESIS; LISTERIA; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROKARYOTE; SHORT SURVEY; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS; TEMPERATURE; ARTICLE; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION;

BACILLUS SUBTILIS; EUKARYOTA; PROKARYOTA;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 74949084359     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.296pe71     Document Type: Short Survey

References (23)

1. J. Fuhrmann, A. Schmidt, S. Spiess, A. Lehner, K. Turgay, K. Mechtler, E. Charpentier, T. Clausen, McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science 324, 1323-1327 (2009).
2. R. Gao, A. M. Stock, Biological insights from structures of two-component proteins. Annu. Rev. Microbiol. 63, 133-154 (2009).
3. A. M. Stock, V. L. Robinson, P. N. Goudreau, Twocomponent signal transduction. Annu. Rev. Biochem. 69, 183-215 (2000).
4. R. Heermann, A. Weber, B. Mayer, M. Ott, E. Hauser, G. Gabriel, T. Pirch, K. Jung, The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress. J. Mol. Biol. 386, 134-148 (2009).
5. L. Tetsch, K. Jung, The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria. Mol. Microbiol. 73, 982-991 (2009).
6. A. Kato, A.Y. Mitrophanov, E. A. Groisman, A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Proc. Natl. Acad. Sci. U.S.A. 104, 12063-12068 (2007).
7. R. Paul, T. Jaeger, S. Abel, I. Wiederkehr, M. Folcher, E. G. Biondi, M. T. Laub, U. Jenal, Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. Cell 133, 452-461 (2008).
8. R. E. Chen, J. Thorner, Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1773, 1311-1340 (2007).
9. J. Pérez, A. Castañeda-García, H. Jenke- Kodama, R. Müller, J. Muñoz-Dorado, Eukaryoticlike protein kinases in the prokaryotes and the myxobacterial kinome. Proc. Natl. Acad. Sci. U.S.A. 105, 15950-15955 (2008).
10. L. J. Jensen, M. Kuhn, M. Stark, S. Chaffron, C. Creevey, J. Muller, T. Doerks, P. Julien, A. Roth, M. Simonovic, P. Bork, C. von Mering, STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 37, (Database issue), D412-D416 (2009).
11. W. Schumann, The Bacillus subtilis heat shock stimulon. Cell Stress Chaperones 8, 207-217 (2003).
12. J. Kirstein, K. Turgay, A new tyrosine phosphorylation mechanism involved in signal transduction in Bacillus subtilis. J. Mol. Microbiol. Biotechnol. 9, 182-188 (2005).
13. I. Derré, G. Rapoport, T. Msadek, CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria. Mol. Microbiol. 31, 117-131 (1999).
14. J. Kirstein, D. A. Dougan, U. Gerth, M. Hecker, K. Turgay, The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J. 26, 2061-2070 (2007).
15. A. F. Neuwald, L. Aravind, J. L. Spouge, E. V. Koonin, AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 9, 27-43 (1999).
16. J. Kirstein, N. Moliére, D. A. Dougan, K. Turgay, Adapting the machine: Adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat. Rev. Microbiol. 7, 589-599 (2009).
17. U. Gerth, J. Kirstein, J. Mostertz, T. Waldminghaus, M. Miethke, H. Kock, M. Hecker, Fine-tuning in regulation of Clp protein content in Bacillus subtilis. J. Bacteriol. 186, 179-191 (2004).
18. E. Krüger, M. Hecker, The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes. J. Bacteriol. 180, 6681-6688 (1998).
19. I. Derré, G. Rapoport, T. Msadek, The CtsR regulator of stress response is active as a dimer and specifically degraded in vivo at 37°C. Mol. Microbiol. 38, 335-347 (2000).
20. E. Krüger, D. Zühlke, E. Witt, H. Ludwig, M. Hecker, Clp-mediated proteolysis in Gram-positive bacteria is autoregulated by the stability of a repressor. EMBO J. 20, 852-863 (2001).
21. W. R. Ellington, Evolution and physiological roles of phosphagen systems. Annu. Rev. Physiol. 63, 289-325 (2001).
22. H. R. Matthews, Protein kinases and phosphatases that act on histidine, lysine, or arginine residues in eukaryotic proteins: A possible regulator of the mitogen-activated protein kinase cascade. Pharmacol. Ther. 67, 323-350 (1995).
23. B. T. Wakim, G. D. Aswad, Ca(2+)-calmodulin-dependent phosphorylation of arginine in histone 3 by a nuclear kinase from mouse leukemia cells. J. Biol. Chem. 269, 2722-2727 (1994).