Rapid and specific high-performance liquid chromatography for the in vitro quantification of D-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products

Biomedical Chromatography

Volumn 24, Issue 2, 2010, Pages 132-139

  Kafka, Alexandra P ^a   Rades, Thomas ^a   McDowell, Arlene ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

MALDI TOF; Microemulsion; Oxidation; Proteins and peptides; Tryptophan

Indexed keywords

AMINO ACIDS; GRADIENT METHODS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROEMULSIONS; OXIDATION;

GRADIENT'S METHODS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; IN-VITRO; JUPITERS; MALDI-TOF; MICRO-EMULSION MATRICES; OXIDATION PRODUCTS; PEPTIDE OXIDATION; PROTEIN AND PEPTIDE; TRYPTOPHAN;

PEPTIDES;

GONADORELIN; GONADORELIN[6 DEXTRO LYSINE]; LYSINE; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROEMULSION; OXIDATION; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS;

EID: 74849096858     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1261     Document Type: Article

References (16)

1. Beauchesne PR, Chung NSC and Wasan KM. Cyclosporine A: a review of current oral and intravenous delivery systems. Drug Development and Industrial Pharmacy 2007; 33: 211-220.
2. Biemann K. Nomenclature for peptide fragment ions (positive-ions). Methods in Enzymology 1990; 193: 886-887.
3. Bilati U, Allemann E and Doelker E. Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles. European Journal of Pharmaceutics and Biopharmaceutics 2005; 59: 375-388.
4. Constantinides PP, Welzel G, Ellens H, Smith PL, Sturgis S, Yiv SH and Owen AB. Water-in-oil microemulsions containing medium-chain fatty acids salts: formulation and intestinal absorption enhancement evaluation. Pharmaceutical Research 1996; 13: 210-215.
5. FDA. Reviewer Guidance: Validation of Chromatographic Methods. Centre for Drug Evaluation and Research (CDER) 1994.
6. FDA. Guidance for Industry: Bioanalytical Method Validation. Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine, 2001.
7. Finley EL, Dillon J, Crouch RK and Schey KL. Identification of tryptophan oxidation products in bovine alpha-crystallin. Protein Science 1998; 7: 2391-2397.
8. Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC and Heinecke JW. Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry 2006; 45: 3961-3971.
9. Gupta S, Moulik SP, Hazra B, Ghosh R, Sanyal SK and Datta S. New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound. Drug Delivery 2006; 13: 193-199.
10. ICH F. Guidance for Industry: Q2B Validation of Analytical Procedures: Methodology. Food and Drug Administration, Centre for Drug Evaluation and Research, Centre for Biologics Evaluation and Research, 1996.
11. Peter A, Devadder S, Laus G and Tourwe D. Liquid chromatography studies on the enzymatic degradation of luteinizing hormone-releasing hormone analogues with off-line identification by mass spectrometry. Journal of Chromatography A 1996; 729: 137-142.
12. Simat TJ and Steinhart H. Oxidation of free tryptophan and tryptophan residues in peptides and proteins. Journal of Agricultural and Food Chemistry 1998; 46: 490-498.
13. Taylor SW, Fahy E, Murray J, Capaldi RA and Ghosh SS. Oxidative post-translational modification of tryptophan residues in cardiac mitochondrial proteins. Journal of Biological Chemistry 2003; 278: 19587-19590.
14. Trenktrog T and Muller BW. Preparation and characterization of a peptide-containing w/o emulsion. International Journal of Pharmaceutics 1995; 123: 199-207.
15. Watnasirichaikul S, Davies NM, Rades T and Tucker IG. Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions. Pharmaceutical Research 2000; 17: 684-689.
16. Wen JY, Davies N, Ledger R, Butt G, McLeod B and Tucker IG. Isocratic liquid chromatographic assay for monitoring the degradation of luteinizing hormone releasing hormone by extracts from the gastrointestinal tract of possums. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2002; 779: 221-227.