WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival

Molecular and Cellular Endocrinology

Volumn 317, Issue 1-2, 2010, Pages 106-111

  Jääskeläinen, Minna ^a   Prunskaite Hyyryläinen, Renata ^b   Naillat, Florence ^b   Parviainen, Helka ^c   Anttonen, Mikko ^c   Heikinheimo, Markku ^c,e   Liakka, Annikki ^b   Ola, Roxana ^d   Vainio, Seppo ^b   Vaskivuo, Tommi E ^a   Tapanainen, Juha S ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d Institute of Biomedicine   (Finland)

^e WASHINGTON UNIVERSITY   (United States)

Author keywords

Apoptosis; Granulosa cell; Human ovary; Oocyte; WNT4

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; AROMATASE; MESSENGER RNA; PROTEIN BCL XL; PROTEIN BOK; PROTEIN FOG 2; TRANSCRIPTION FACTOR GATA 4; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; WNT4 PROTEIN;

ADRENAL GLAND; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMERGENCY CONTRACEPTION; FEMALE; FETUS; FETUS DEVELOPMENT; FOLLICULAR PHASE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE MATURATION; OVARY; OVARY DEVELOPMENT; OVARY FOLLICLE MATURATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TESTIS;

ADULT; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MIDDLE AGED; OOCYTES; OVARIAN FOLLICLE; OVARY; RNA, MESSENGER; SIGNAL TRANSDUCTION; WNT PROTEINS; YOUNG ADULT;

EID: 74749109906     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.11.013     Document Type: Article

References (25)

1. Alton M., and Taketo T. Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries. J. Cell. Sci. 120 (2007) 417-424
2. Anttonen M., Ketola I., Parviainen H., Pusa A.K., and Heikinheimo M. FOG-2 and GATA-4 are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol. Reprod. 68 (2003) 1333-1340
3. Barrionuevo F., Bagheri-Fam S., Klattig J., Kist R., Taketo M.M., Englert C., and Scherer G. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol. Reprod. 74 (2006) 195-201
4. Biason-Lauber A., De Filippo G., Konrad D., Scarano G., Nazzaro A., and Schoenle E.J. WNT4 deficiency-a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22 (2007) 224-229
5. Biason-Lauber A., Konrad D., Navratil F., and Schoenle E.J. A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46,XX woman. N. Engl. J. Med. 351 (2004) 792-798
6. Cadigan K.M., and Liu Y.I. Wnt signaling: complexity at the surface. J. Cell. Sci. 119 (2006) 395-402
7. Cadigan K.M., and Nusse R. Wnt signaling: a common theme in animal development. Genes Dev. 11 (1997) 3286-3305
8. Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., and Wilson D.B. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138 (1997) 3505-3514
9. Heikkila M., Peltoketo H., and Vainio S. Wnts and the female reproductive system. J. Exp. Zool. 290 (2001) 616-623
10. Heikkila M., Prunskaite R., Naillat F., Itaranta P., Vuoristo J., Leppaluoto J., Peltoketo H., and Vainio S. The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action. Endocrinology 146 (2005) 4016-4023
11. Hsieh M., Johnson M.A., Greenberg N.M., and Richards J.S. Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary. Endocrinology 143 (2002) 898-908
12. Inoue N., Manabe N., Matsui T., Maeda A., Nakagawa S., Wada S., and Miyamoto H. Roles of tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in granulosa cell apoptosis during atresia in pig ovaries. J. Reprod. Dev. 49 (2003) 313-321
13. Jaaskelainen M., Kyronlahti A., Anttonen M., Nishi Y., Yanase T., Secchiero P., Zauli G., Tapanainen J.S., Heikinheimo M., and Vaskivuo T.E. TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary. Differentiation 77 (2009) 369-376
14. Jeays-Ward K., Hoyle C., Brennan J., Dandonneau M., Alldus G., Capel B., and Swain A. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130 (2003) 3663-3670
15. Kim Y., Kobayashi A., Sekido R., DiNapoli L., Brennan J., Chaboissier M.C., Poulat F., Behringer R.R., Lovell-Badge R., and Capel B. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 4 (2006) e187
16. Oreal E., Mazaud S., Picard J.Y., Magre S., and Carre-Eusebe D. Different patterns of anti-Mullerian hormone expression, as related to DMRT1, SF-1, WT1, GATA-4, Wnt-4, and Lhx9 expression, in the chick differentiating gonads. Dev. Dyn. 225 (2002) 221-232
17. Ottolenghi C., Pelosi E., Tran J., Colombino M., Douglass E., Nedorezov T., Cao A., Forabosco A., and Schlessinger D. Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum. Mol. Genet. 16 (2007) 2795-2804
18. Perez G.I., Robles R., Knudson C.M., Flaws J.A., Korsmeyer S.J., and Tilly J.L. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat. Genet. 21 (1999) 200-203
19. Philibert P., Biason-Lauber A., Rouzier R., Pienkowski C., Paris F., Konrad D., Schoenle E., and Sultan C. Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and mullerian duct abnormalities: a French collaborative study. J. Clin. Endocrinol. Metab. 93 (2008) 895-900
20. Rucker III E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., and Hennighausen L. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14 (2000) 1038-1052
21. Stark K., Vainio S., Vassileva G., and McMahon A.P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372 (1994) 679-683
22. Vainio S., Heikkila M., Kispert A., Chin N., and McMahon A.P. Female development in mammals is regulated by Wnt-4 signalling. Nature 397 (1999) 405-409
23. Vaskivuo T.E., Anttonen M., Herva R., Billig H., Dorland M., te Velde E.R., Stenback F., Heikinheimo M., and Tapanainen J.S. Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4. J. Clin. Endocrinol. Metab. 86 (2001) 3421-3429
24. Yao H.H., Matzuk M.M., Jorgez C.J., Menke D.B., Page D.C., Swain A., and Capel B. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev. Dyn. 230 (2004) 210-215
25. Yu H., Pask A.J., Shaw G., and Renfree M.B. Differential expression of WNT4 in testicular and ovarian development in a marsupial. BMC Dev. Biol. 6 (2006) 44