Reduction in postlaminectomy epidural adhesions in sheep using a fibrin sealant-based medicated adhesion barrier

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 92, Issue 2, 2010, Pages 439-446

  Richards, Peter J ^a,b   Turner, A Simon ^c   Gisler, Serge M ^a   Kraft, Susan ^c   Nuss, Katja ^b   Mark, Silke ^a,b   Seim III, Howard B ^c   Schense, Jason ^a  

^a Kuros Biosurgery   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Epidural adhesion; Fibrin sealant; Laminectomy; Sheep; Tributyrin

Indexed keywords

ADHESION BARRIER; ADVERSE EVENTS; FIBRIN GELS; FIBRIN SEALANTS; FIBROBLAST PROLIFERATION; HISTOLOGICAL EXAMINATION; IN-VITRO ANALYSIS; LAMINECTOMY; RESORBABLE; REVISION SURGERY; SPINAL SURGERY; TIME-DEPENDENT; TRIBUTYRIN;

CELL CULTURE; GELS; MAGNETIC RESONANCE IMAGING; RESONANCE; SEALANTS; SURGERY; TISSUE; WOOL;

ADHESION;

FIBRIN GLUE; MEDICATED ADHESION BARRIER; TISSUE ADHESIVE; TRIBUTYRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; EPIDURAL ADHESION; FIBROBLAST; FIBROSIS; HISTOPATHOLOGY; IN VITRO STUDY; INCIDENCE; LAMINECTOMY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTOPERATIVE COMPLICATION; SHEEP; TREATMENT OUTCOME;

ANIMALS; CELL PROLIFERATION; EPIDURAL SPACE; FEMALE; FIBRIN TISSUE ADHESIVE; FIBROBLASTS; HUMANS; LAMINECTOMY; MAGNETIC RESONANCE IMAGING; PAIN, POSTOPERATIVE; PARAFFIN EMBEDDING; POSTOPERATIVE COMPLICATIONS; SHEEP; TISSUE ADHESIONS; TISSUE ADHESIVES; TISSUE FIXATION; TRIGLYCERIDES;

EID: 74749107176     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31533     Document Type: Article

References (50)

1. Ross JS, Robertson JT, Frederickson RC, Petrie JL, Obuchowski N, Modic MT, deTribolet N. Association between peridural scar and recurrent radicular pain after lumbar discectomy: Magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery 1996;8:855-863.
2. Parke WW, Watanabe R. Adhesions of the ventral lumbar dura. An adjunct source of discogenic pain? Spine 1990;15: 300-303.
3. Kim KD, Wang JC, Robertson DP, Brodke DS, Olson EM, Duberg AC, BenDebba M, Block KM, diZerega GS. Reduction of radiculopathy and pain with Oxiplex/SP Gel after laminectomy, laminotomy and discectomy: A pilot clinical study. Spine 2003;28:1080-1087.
4. Gambardella G, Gervasio O, Zaccone C, Puglisi E. Prevention of recurrent radicular pain after lumbar disc surgery: A prospective study. Acta Neurochir Suppl 2005;92:151-154.
5. BenDebba M, Augustus van Alphen H, Long DM. Association between peridural scar and activity-related pain after lumbar discectomy. Neurol Res 1999;21 Suppl 1:S37-S42.
6. Maroon JC, Abla A, Bost J Association between peridural scar and persistent low back pain after lumbar discectomy. Neurol Res 1999;21:S43-S46.
7. Manchikanti L, Saini B, Singh V. Spinal endoscopy and lysis of epidural adhesions in the management of chronic low back pain. Pain Physician 2001;3:240-265.
8. de Tribolet N, Porchet F, Lutz TW, Gratzi O, Brotchi J, van Alphen HA, van Acker RE, Benini A, Strommer KN, Bernays RL, Goffin J, Beuls EA, Ross JS. Clinical assessment of a novel antiadhesion barrier gel: Prospective, randomized, multicenter, clinical trial of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms after lumbar discectomy. Am J Orthop 1998;27:111-120.
9. Kuivila TE, Berry JL, Bell GR, Steffee AD. Heparinized materials for control of the formation of the laminectomy membrane in experimental laminectomies in dogs. Clin Orthop Relat Res 1988;236:166-174.
10. Benoist M, Ficat C, Baraf P, Cauchoix J. Postoperative lumbar epiduro-arachnoiditis. Diagnostic and therapeutic aspects. Spine 1980;5:432-436.
11. Pheasant H. Sources of failure in laminectomies. Orthop Clin North Am 1975;6:319-329.
12. Kayaoglu CR, Calikoglu C, Binler S. Re-operation after lumbar disc surgery: Results in 85 cases. J Int Med Res 2003;31: 318-323.
13. Key JA, Ford LT. Experimental intervertebral disc lesions. J Bone Joint Surg Am 1948;30:621-630.
14. LaRocca H, MacNab I. The laminectomy membrane. Studies in its evolution, characteristics, effects and prophylaxis in dogs. J Bone Joint Surg Br 1974;56:545-550.
15. Songer MN, Ghosh L, Spencer DL. Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs. Spine 1995;20:571-580.
16. Yucesoy K, Karci A, Kilicalp A, Mertol T. The barrier effect of laminae: Laminotomy versus laminectomy. Spinal Cord 2000;38:442-444.
17. Ozer AF, Oktenoglu T, Sasani M, Bozkus H, Canbulat N, Karaarslan E, Sungurlu SF, Sarioglu AC. Preserving the ligamentum flavum in lumbar discectomy: A new technique that prevents scar tissues formation in the first 6 months postsurgery. Neurosurgery 2006;59(suppl 1):26-33.
18. Hinton JL Jr, Warejcka DJ, Mei Y, McLendon RE, Laurencin C, Lucas PA, Robinson JS Jr. Inhibition of epidural scar formation after laminectomy in the rat. Spine 1995;20:564-570.
19. Nakano M, Matsui H, Miaki K, Tsuji H. Postlaminectomy adhesion of the cauda equina. Inhibitory effects of anti-inflammatory drugs on cauda equina adhesion in rats. Spine 1998; 23:298-304.
20. Lee JY, Stenzel W, Ebel H, Wedekind C, Ernestus RI, Klug N. Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats. J Neurosurg (Spine 1) 2004;100: 52-55.
21. Lee JY, Stenzel W, Impekoven P, Theisohn M, Stützer H, Löhr M, Reitmeier T, Ernestus RI, Ebel H, Klug N. The effect of mitomycin C in reducing epidural fibrosis after lumbar laminectomy in rats. J Neurosurg Spine 2006;5:53-60.
22. Gill GG, Sakovich L, Thompson E. Pedicle fat grafts for the prevention of scar formation after laminectomy. An experimental study in dogs. Spine 1979;4:176-186.
23. Songer MN, Ghosh L, Spencer DL. Effects of sodium hyaluronate on peridural .brosis after lumbar laminotomy and discectomy. Spine 1990;15:550-554.
24. Akeson WH, Massie JB, Huang B, Giurea A, Sah R, Garfin SR, Kim CW. Topical high-molecular-weight hyaluronan and a roofing barrier sheet equally inhibit postlaminectomy fibrosis. Spine J 2005;5:180-190.
25. Liu S, Boutrand JP, Bittoun J, Tadie M. A collagen-based sealant to prevent in vivo reformation of epidural scar adhesions in an adult rat laminectomy model. J Neurosurg (Spine 1) 2002;97:69-74.
26. Jacobs RR, McClain O, Neff J. Control of postlaminectomy scar formation: An experimental and clinical study. Spine 1980;5:223-229.
27. Klopp LS, Welch WC, Tai JW, Toth JM, Cornwall GB, Turner AS. Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model. Neurosurg Focus 2004;16:1-9.
28. Klopp LS, Simon BJ, Bush JM, Turner AS. Comparison of a Caprolactone/Lactide Film (Mesofol) to two polylactide film products as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model. Spine 2008;33:1518-1526.
29. Einhaus SL, Robertson JT, Dohan FC Jr, Wujek JR, Ahmad S. Reduction of peridural fibrosis after lumbar laminotomy and discectomy in dogs by a resorbable gel (ADCON-L). Spine 1997;22:1440-1447.
30. Rodgers KE, Robertson JT, Espinoza T, Oppelt W, Cortese S, diZerega GS, Berg RA. Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide. Spine J 2003;3:277-284.
31. Pomeranz S, Constantini S, Umansky F. The use of fibrin sealant in cerebrospinal fluid leakage. Neurochirurgia 1991; 34:166-169.
32. Sawamura Y, Asaoka K, Terasaka S, Tada M, Uchida T. Evaluation of application techniques of fibrin sealant to prevent cerebrospinal fluid leakage: A new device for the application of aerosolized fibrin glue. Neurosurgery 1999;44:332-337.
33. Shaffrey CI, Spotnitz WD, Shaffrey ME, Jane JA. Neurological applications of fibrin glue: Augmentation of dural closure in 134 patients. Neurosurgery 1990;26:207-210.
34. Vaquero J, Arias A, Oya S, Martinez R, Zurita M. Effect of fibrin glue on postlaminectomy scar formation. Acta Neurochir (Wien) 1993;120:159-163.
35. Robertson JT, Soble-Smith J, Powers N, Nelson PA. Prevention of cerebrospinal .stulae and reduction of epidural scar with new surgical hemostat device in a porcine laminectomy model. Spine 2003;28:2298-2303.
36. Clarke KO, Feinman R, Harrison LE. Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3. Cancer Letters 2001;171:57-65.
37. Schroder CP, Maurer HR. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol 2002;20:195-200.
38. Schroder C, Eckert K, Maurer HR. Tributyrin induces growth inhibitory and differentiating effects on HT-29 colon cancer cells in vitro. Int J Oncol 1998;13:1335-1340.
39. Conley BA, Egorin MJ, Tait N, Rosen DM, Sausville EA, Dover G, Fram RJ, Van Echo DA. Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors. Clin Cancer Res 1998;4:629-634.
40. Edelman MJ, Bauer K, Khanwani S, Tait N, Trepel J, Karp J, Nemieboka N, Chung EJ, Van Echo D. Clinical and pharmacologic study of tributyrin: An oral butyrate prodrug. Cancer Chemother Pharmacol 2003;51:439-444.
41. Sen O, Kizilkilic O, Aydin MV, Yalcin O, Erdogan B, Cekinmez M, Caner H, Altinors N. The role of closed-suction drainage in preventing epidural fibrosis and its correlation with a new grading system of epidural fibrosis on the basis of MRI. Eur Spine J 2005;14:409-414.
42. Brotchi J, Pirotte B, De Witte O, Levivier M. Prevention of epidural fibrosis in a prospective series of 100 primary lumbo-sacral discectomy patients: Follow-up and assessment at re-operation. Neurol Res 1999;21(suppl 1):S47-S50.
43. Schroder CP, Maurer HR. Tributyrin enhances the cytotoxic activity of interleukin-2/interleukin-12 stimulated human natural killer cells against LS 174T colon cancer cells in vitro. Cancer Immunol Immunother 2001;50:69-76.
44. Kuefer R, Hofer MD, Altug V, Zorn C, Genze F, Kuni-Rapp K, Hautmann RE, Gschwend JE. Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer. Br J Cancer 2004;90:535-541.
45. Heerdt BG, Houston MA, Anthony GM, Auegentlicht LH. Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity. Cancer Res 1999;59:1584-1591.
46. Lallemand F, Courilleau D, Buquet-Fagot C, Atfi A, Montagne MN, Mester J. Sodium butyrate induces G2 arrest in the human breast cancer cells MDA-MB-231 and renders them competent for DNA replication. Exp Cell Res 1999;247: 432-440.
47. Kim KD, Wang JC, Robertson DP, Brodke DS, BenDebba M, Block KM, diZerega GS. Reduction of leg pain and lower-extremity weakness for 1 year with Oxiplex/SP Gel following laminectomy, laminotomy, and discectomy. Neurosurg Focus 2004;17:1-6.
48. Hieb LD, Stevens DL. Spontaneous postoperative cerebrospinal fluid leaks following application of anti-adhesion barrier gel: Case report and review of the literature. Spine 2001;26: 748-751.
49. Tatsui CE, Martinez G, Li X, Pattany P, Levi AD. Evaluation of DuraGen in preventing peridural fibrosis in rabbits. J Neurosurg Spine 2006;4:51-59.
50. Preul MC, Campbell PK, Bennett SL, Muench TR. A unique dual-function device: A dural sealant with adhesion prevention properties. Eur Musculoskeletal Rev 2006;September: 41-44.