Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 1, 2010, Pages 11-15

  Han, Dong Han ^a   Jin, Zhe Hu ^a   Jin, Yan Zhe ^a   Yin, Xue Zhe ^a   Shen, Yuan Yuan ^b   Gao, Zhong Gao ^a,b,c  

^a YANBIAN UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

Bioavailability; Caco 2 cell line; The apparent permeability; Thermal reversible microemulsion; YH439

Indexed keywords

2 (1,3 DITHIETAN 2 YLIDENE) 2 [N (4 METHYL 2 THIAZOLYL)CARBAMOYL]ACETIC ACID ISOPROPYL ESTER; CARBOXYMETHYLCELLULOSE; CREMOPHOR; DECANOIC ACID; FATTY ACID; GELUCIRE; MACROGOL 400; PALMITIC ACID; SURFACTANT; TRANSWELL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MELTING POINT; MICROEMULSION; MONOLAYER CULTURE; NONHUMAN; PARTICLE SIZE; POWDER; RAT; TEMPERATURE ACCLIMATIZATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; DECANOIC ACIDS; EMULSIONS; HUMANS; MALE; PALMITIC ACID; PERMEABILITY; POLYETHYLENE GLYCOLS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE-ACTIVE AGENTS; THIAZOLES;

EID: 74749094618     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.11     Document Type: Article

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