Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney

Histology and Histopathology

Volumn 25, Issue 1, 2010, Pages 33-44

  Hwang, Jin Sun ^a   Park, Eun Young ^a   Kim, Wan Young ^a   Yang, Chul Woo ^a   Kim, Jin ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Immunohistochemistry; Mouse kidney; OAT1; OAT3; Proximal tubule

Indexed keywords

AQP1 PROTEIN, MOUSE; AQP4 PROTEIN, MOUSE; AQUAPORIN 1; AQUAPORIN 4; BICARBONATE SODIUM COTRANSPORTER; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; SLC22A6 PROTEIN, MOUSE; SLC4A4 PROTEIN, MOUSE;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; METABOLISM; MOUSE;

ANIMALS; ANTIBODY SPECIFICITY; AQUAPORIN 1; AQUAPORIN 4; CELL DIFFERENTIATION; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED C57BL; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; SODIUM-BICARBONATE SYMPORTERS;

EID: 74749089277     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Alexander D.P. and Nixon D.A. (1962). Plasma clearance of p-aminohippuric acid by the kidneys of fetal neonatal and adult sheep. Nature 194, 483-484.
2. Anzai N., Kanai Y. and Endou H. (2006). Organic anion transporter family: current knowledge. J. Pharmacol. Sci. 100, 1411-1426.
3. Bahn A., Ljubojevic M., Lorenz H., Schultz C., Ghebremedhin E., Ugele B., Sabolic I., Burckhardt G. and Hagos Y. (2005). Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am. J. Physiol. Cell Physiol. 289, C1075-C1084.
4. Brady K.P., Dushkin H.F., Ornzler D., Koike T., Magner F., Her H., Gullans S., Segre G.V., Green R.M. and Berier D.R. (1999). A novel putative transporter maps to the Osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56, 254-261.
5. Braunlich H. (1988). Hormonal control of postnatal development of renal tubular transport of weak organic acids. Pediatr. Nephrol. 2, 151-155.
6. Buist S.C., Cherrington N.J., Choudhuri S., Hartley D.P. and Klaassen C.D. (2002). Gender-specific and developmental influences on the expression of rat organic anion transporters. J. Pharmacol. Exp. Ther. 301, 145-151.
7. Buist S.C. and Klaassen C.D. (2004). Rat and mouse differences in gender-predominant expression of organic anion transporter (OAT1-3; slc22a6-8) mRNA levels. Drug Metab. Dispos. 32, 620-625.
8. Burckhardt B.C. and Burckhardt G. (2003). Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev. Physiol. Biochem. Pharmacol. 146, 95-158.
9. Burckhardt G. and Wolff N.A. (2000). Structure of renal organic anion and cation transporters. Am. J. Physiol. Renal Physiol. 278, F853-F866.
10. Carnegie J.A. and Robertson H.A. (1978). Conjugated and unconjugated estrogens in fetal and maternal fluids of the pregnant ewe: a possible role for estrogene sulfate during early pregnancy. Biol. Reprod. 19, 202-211.
11. Dantzler W.H. and Wright S.H. (2003). The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules. Biochim. Biophys. Acta 1618, 185-193.
12. Elbourne I., Lumbers E.R. and Hill K.J. (1990). The secretion of organic acids and bases by the ovine fetal kidney. Exp. Physiol. 95, 211-221.
13. Endo Y., Yamazaki S., Moriyama N., Li Y., Ariizumi T., Kudo A., Kawakami H., Tanaka Y., Horita S., Yamada H., Seki G. and Fujita T. (2006). Localization of NBC1 variants in rat kidney. Nephron Physiol. 104, 87-94.
14. Eraly S.A., Hamilton B.A. and Nigam S.K. (2003). Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem. Biophys. Res. Commun. 300, 333-342.
15. Eraly S.A., Vallon V., Vaughn D.A., Gangoiti J.A., Richter K., Nagle M., Monte J.C., Rieg T., Truong D.M., Long J.M., Barshop B.A., Kaler G. and Nigam S.K. (2006). Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice. J. Biol. Chem. 281, 5072-5083.
16. Fetterman G.H., Shuplock N.A., Philipp F.J. and Gregg H.S. (1965). The growth and maturation of human gromeruliand proximal convolutions from term to adulthood: studies by microdissection. Pediatrics 35, 601-619.
17. Hirsch G.H. and Hook J.B. (1970). Maturation of renal organic acid transport: substrate stimulation by penicillin and paminohippurate (PAH). J. Pharmacol. Exp. Ther. 171, 103-108.
18. Hook J.B. and Hewitt W.R. (1977). Development of mechanisms for drug excretion. Am. J. Med. 62, 497-506.
19. Horster M. and Lewy J.E. (1970). Filtration fraction and extraction of PAH during the neonatal period in the rat. Am. J. Physiol. 219, 1061-1065.
20. Hosoyamada, M., Sekine T., Kanai Y. and Endou H. (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. Renal Physiol. 276, F122-F128.
21. Kim J., Kim W.Y., Han K.H., Knepper M.A., Nielsen S. and Madsen K.M. (1999). Developmental expression of aquaporin-1 in the rat renal vasculature. Am. J. Physiol. 276, F498-F509.
22. Kim Y.H., Kim J., Earm J.H., Togui M., Verkman A.S., Knepper M.A. and Madsen K.M. (2001). AQP4 expression in adult and developing mouse and rat kidney. J. Am. Soc. Nephrol. 12, 1795-1804.
23. Klaassen C.D. and Lu H. (2008). Xenobiotic transporters: ascribing function from gene knockout and mutation studies. Toxicol. Sci. 101, 186-196.
24. Kleinman L.I. and Lubbe J.E. (1972). Factors affecting the maturation of renal PAH extraction in the newborn dog. J. Physiol. 223, 411-418.
25. Kojima R., Sekine T., Kawachi M., Cha S.H., Suzuki Y. and Endou H. (2002). Immunolocalization of a novel multispecific organic anion transporters, OAT1, OAT2, and OAT3 in rat kidney. J. Am. Soc. Nephrol. 13, 848-857.
26. Leazer T.M. and Klaassen C.D. (2003). The presence of xenobiotic transporters in rat placenta. Drug Metab. Dispos. 31, 153-167.
27. Ljubojevic M., Herak-Kramberger C.M., Hagos Y., Bahn A., Endou H., Burckhardt G. and Sabolic I. (2004). Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am. J. Physiol. Renal. Physiol. 287, F124-F138.
28. Nakajima N., Sekine T., Cha S.H., Tojo A., Hosoyamada M., Kanai Y., Yan K., Awa S. and Endou H. (2000). Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int. 57, 1608-1616.
29. Ohtsuki S., Kikkawa T., Mori S., Hori S., Takanaga H., Otagiri M. and Terasaki T. (2004). Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J. Pharmacol. Exp. Ther. 309, 1273-1281.
30. Pavlova A., Skakurai H., Leclercq B., Beier D.R., Yu A.S. and Nigam S.K. (2000). Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2) and Roct. Am. J. Physiol. Renal Physiol. 278, F635-F643.
31. Race J.E., Grassl S.M., Williams W.J. and Holtzman E.J. (1999). Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem. Biophys. Res. Commun. 255, 508-514.
32. 4) variants in rat kidney and pancreas. Biochem. Biophys. Res. Commun. 314, 382-389.
33. Sabolić I., Herak-Kramberger C.M., Breton S. and Brown D. (1999). Na/K-ATpase in intercalated celsl allong the rat nephron revealed by antigen retrieval. Am. Soc. Nephrol. 10. 913-922.
34. Sabolić I., Valenti G., Verbavatz J.M., Van Hoek A.N., Verkman A.S., Ausiello D.A. and Brown D. (1992). Localization of the CHIP28 water channel in rat kidney. Am. J. Physiol. 263, C1225-C1233.
35. Sekine T., Watanabe M., Hosoyamada M., Kanai Y. and Endou H. (1997). Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272, 18526-18529.
36. Shimomura A., Chonko A.M. and Grantham J.J. (1981). Basis for heterogeneity of para-aminohippurate secretion in rabbit proximal tubules. Am. J. Physiol. 240, F430-F436.
37. St-Pierre M.V., Stallmach T., Freimoser G.A., Dufour J.F., Serrano M.A., Marin J.J., Sugiyama Y. and Meier P.J. (2004). Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R1505-R1516.
38. Stopp M., Hartwich R. and Braunlich H. (1978). Enhancement of paminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages. Experientia 34, 1493-1494.
39. Sweet D.H., Bush K.T. and Nigam S.K. (2001). The organic anion transporter family: from physiology to ontogeny and the clinic. Am. J. Physiol. Renal Physiol. 281, F197-F205.
40. Sweet D.H., Miller D.S., Pritchard J.B., Fujiwara Y., Beier D.R. and Nigam S.K. (2002). Impaired organic anion transport in kidney and choroids plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J. Biol. Chem. 277, 26934-26943.
41. Sweet D.H., Chan L.M., Walden R., Yang X.P., Miller D.S. and Pritchard J.B. (2003). Organic anion transporter3 (slc22a8) is adicarboxylate exchanger indirectly coupled to the Na+ gradient. Am. J. Physiol. Renal Physiol. 284, F763-F791.
42. Sweet D.H., Eraly S.A., Vaughn D.A., Bush K.T. and Nigam S.K. (2006). Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int. 69, 837-845.
43. Tojo A., Sekine T., Nakajima N., Hosoyamada M., Kanai Y., Kimura K. and Endou H. (1999). Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol. 10, 464-471.
44. Ullrich K.J. (1997). Renal transporters for organic anions and organic cations. Structural requirements for substrates. J. Memb. Biol. 158, 95-107.
45. Wolff N.A., Werner A., Burkhardt S. and Burckhardt G. (1997). Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett. 417, 287-291.
46. Wood C.E., Cousins R., Zhang D. and Keller-Wood M. (2005). Ontogeny and expression of organic anion transporters 1 and 3 ovine fetal and neonatal kidney. Exp. Biol. Med. 230, 668-673.
47. Wright S.H. and Dantzler W.H. (2004). Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev. 84, 987-1049.
48. Youngblood G.L. and Sweet D.H. (2004). Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am. J. Physiol. Renal Physiol. 287, F236-F244.
49. Zhou F. and You G. (2007). Molecular insights into the structure-function relationship of organic anion transporters OATs. Pharm. Res. 24, 28-36.