Role of mesenchymal stem cells in immunological rejection of organ transplantation

Stem Cell Reviews and Reports

Volumn 5, Issue 4, 2009, Pages 402-409

  Zhang, Xiaomin ^a   Jiao, Chunna ^a   Zhao, Shaozhen ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Cell therapy; Immune modulation; Immunological rejection; Mesenchymal stem cells; Organ transplantation

Indexed keywords

ANIMAL; ARTICLE; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; ORGAN TRANSPLANTATION;

ANIMALS; GRAFT REJECTION; HUMANS; IMMUNE TOLERANCE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; ORGAN TRANSPLANTATION;

ANIMALIA;

EID: 74649085434     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-009-9076-y     Document Type: Article

References (50)

1. Friedenstein, A. J., Gorskaja, J. F., & Kulagina, N. N. (1976). Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Experimental Hematology, 4, 267-74.
2. Patel, S. A., Sherman, L., Munoz, J., & Rameshwar, P. (2008). Immunological properties of mesenchymal stem cells and clinical implications. Archivum Immunologiae et Therapiae Experimentalis (Warsz), 56, 1-8. doi:10.1007/s00005-008-0001-x.
3. Di Nicola, M., Carlo-Stella, C., Magni, M., et al. (2002). Human bone marrow stromal cells suppress Tlymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 99, 3838-43. doi:10.1182/blood. V99. 10. 3838.
4. Le Blanc, K., Tammik, L., Sundberg, B., Haynesworth, S. E., & Ringden, O. (2003). Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scandinavian Journal of Immunology, 57, 11-20. doi:10.1046/j. 1365-3083.2003. 01176. x.
5. Potian, J. A., Aviv, H., Ponzio, N. M., Harrison, J. S., & Rameshwar, P. (2003). Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. Journal of Immunology, 171, 3426-34.
6. Tse, W. T., Pendleton, J. D., Beyer, W. M., Eqalka, M. C., & Guinan, E. C. (2003). Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation, 75, 389-97. doi:10.1097/01. TP. 0000045055. 63901. A9.
7. Bartholomew, A., Sturgeon, C., Siatskas, M., et al. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Experimental Hematology, 30, 42-8. doi:10.1016/S0301-472X(01)00769-X.
8. Djouad, F., Plence, P., Bony, C., et al. (2003). Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood, 102, 3837-44. doi:10.1182/blood-2003-04-1193.
9. Krampera, M., Glennie, S., Dyson, J., et al. (2003). Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood, 101, 3722-9. doi:10.1182/blood-2002-07-2104.
10. Augello, A., Tasso, R., Negrini, S. M., et al. (2005). Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. European Journal of Immunology, 35, 1482-90. doi:10.1002/eji.200425405.
11. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995). Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology, 155, 1151-64.
12. Blazar, B. R., & Taylor, P. A. (2005). Regulatory T cells. Biology of Blood and Marrow Transplantation, 11, 46-94. doi:10.1016/j. bbmt.2004. 11. 005.
13. Aggarwal, S., & Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105, 1815-22. doi:10.1182/blood-2004-04-1559.
14. Maccario, R., Podesta, M., Moretta, A., et al. (2005). Interaction of human mesenchymal stem cells with cells involved in alloantigenspecific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica, 90, 516-25.
15. Le Blanc, K., Rasmusson, I., Gǒtherstroǒm, C., et al. (2004). Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scandinavian Journal of Immunology, 60, 307-15. doi:10.1111/j. 0300-9475.2004. 01483. x.
16. Beyth, S., Borovsky, Z., Mevorach, D., et al. (2005). Human mesenchymal stemcells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood, 105, 2214-9. doi:10.1182/blood-2004-07-2921.
17. Rasmusson, I., Ringden, O., Sundberg, B., & Le Blanc, K. (2003). Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation, 76, 1208-13. doi:10.1097/01. TP. 0000082540. 43730. 80.
18. Zappia, E., Casazza, S., Pedemonte, E., et al. (2005). Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 106, 1755-61. doi:10.1182/blood-2005-04-1496.
19. Dazzi, F., Ramasamy, R., Glennie, S., Jones, S. P., & Roberts, I. (2006). The role of mesenchymal stem cells in haemopoiesis. Blood Reviews, 20, 161-71. doi:10.1016/j. blre.2005. 11. 002.
20. Akasaki, Y., Liu, G., Chung, N. H., et al. (2004). Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. Journal of Immunology, 173, 4352-9.
21. Deans, R. J., & Moseley, A. B. (2000). Mesenchymal stem cells: Biology and potential clinical uses. Experimental Hematology, 28, 875-84. doi:10.1016/S0301-472X(00)00482-3.
22. Liu, J., Lu, X. F., Wan, L., et al. (2004). Suppression of human peripheral blood lymphocyte proliferation by immortalized mesenchymal stem cells derived from bone marrow of Banna Minipig inbredline. Transplantation Proceedings, 36, 3272-5. doi:10.1016/j. transproceed.2004. 11. 090.
23. Glennie, S., Soeiro, I., Dyson, P. J., Lam, E. W., & Dazzi, F. (2005). Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood, 105, 2821-7. doi:10.1182/blood-2004-09-3696.
24. Corcione, A., Benvenuto, F., Ferretti, E., et al. (2006). Human mesenchymal stem cells modulate B-cell functions. Blood, 107, 367-72. doi:10.1182/blood-2005-07-2657.
25. Krampera, M., Cosmi, L., Angeli, R., et al. (2006). Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells, 24, 386-98. doi:10.1634/stemcells.2005-0008.
26. Spaggiari, G. M., Capobianco, A., Becchetti, S., Mingari, M. C., & Moretta, L. (2006). Mesenchymal stem cellnatural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood, 107, 1484-90. doi:10.1182/blood-2005-07-2775.
27. Sotiropoulou, P. A., Perez, S. A., Gritzapis, A. D., Baxevanis, C. N., & Papamichail, M. (2006). Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells, 24, 74-85. doi:10.1634/stemcells.2004-0359.
28. Jiang, X. X., Zhang, Y., Liu, B., et al. (2005). Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood, 105, 4120-6. doi:10.1182/blood-2004-02-0586.
29. Zhang, W., Ge, W., Li, C., et al. (2004). Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte- derived dendritic cells. Stem Cells and Development, 13, 263-71. doi:10.1089/154732804323099190.
30. Nauta, A. J., Kruisselbrink, A. B., Lurvink, E., Willemzm, R., & Fibbe, W. E. (2006). Mesenchymal stem cells inhibit generation and function of both CD34-derived and monocyte-derived dendritic cells. Journal of Immunology, 177, 2080-7.
31. Rasmusson, I., Ringden, O., Sundberg, B., & Le Blanc, K. (2005). Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Experimental Cell Research, 305, 33-41. doi:10.1016/j. yexcr.2004. 12. 013.
32. Le Blanc, K., Rassmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., et al. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet, 363, 1439-41. doi:10.1016/S0140-6736(04)16104-7.
33. Ringden, O., Uzunel, M., Rasmusson, I., et al. (2006). Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation, 81, 1390-7. doi:10.1097/01. tp. 0000214462. 63943. 14.
34. Le Blanc, K., Samuelsson, H., Gustafsson, B., et al. (2007). Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia, 21, 1733-8. doi:10.1038/sj. leu.2404777.
35. Ball, L. M., Bernardo, M. E., Roelofs, H., Lankester, A., Cometa, A., & Maarten, R. (2007). Cotransplantation of ex vivo expanded mesenchymal stem cells failure accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood, 110, 2764-7. doi:10.1182/blood-2007-04-087056.
36. Le Blanc, K., Frassoni, F., Ball, L., et al. (2008). Mesenchymal stem cells for treatment of steroid-resistant severe, acute graft-versus-host disease: a phase II study. Lancet, 371, 1553-4. doi:10.1016/S0140-6736(08)60666-2.
37. Leal, A., Ichim, T. E., Marleau, A. M., Lara, F., kaushal, S., & Riordan, N. H. (2008). Immune effects of mesenchymal stem cells: implications for Charcot-Marie-Tooth disease. Cellular Immunology, 253, 11-5. doi:10.1016/j. cellimm.2008. 06. 003.
38. Karlsson, H., Samarasinqhe, S., Ball, L. M., et al. (2008). Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses. Blood, 112, 532-41. doi:10.1182/blood-2007-10-119370.
39. Sbano, P., Cuccia, A., Mazzanti, B., et al. (2008). Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model. Archives of Dermatological Research, 300, 115-24. doi:10.1007/s00403-007-0827-9.
40. Aksu, A. E., Horibe, E., Sacks, J., et al. (2008). Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats. Clinical Immunology, 127, 348-58. doi:10.1016/j. clim.2008. 02. 003.
41. Wu, G. D., Nolta, J. A., Jin, Y. S., et al. (2003). Migration of mesenchymal stem cells to heart allografts during chronic rejection. Transplantation, 75, 679-85. doi:10.1097/01. TP. 0000048488. 35010. 95.
42. Inoue, S., Popp, F. C., Koehl, G. E., et al. (2006). Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation, 81, 1589-95. doi:10.1097/01. tp. 0000209919. 90630. 7b.
43. Popp, F. C., Eggenhofer, E., Renner, P., et al. (2008). Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate. Transplant Immunology, 20, 55-60. doi:10.1016/j. trim.2008. 08. 004.
44. Casiraghi, F., Azzollini, N., Cassis, P., et al. (2008). Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. Journal of Immunology, 181, 3933-46.
45. Zhou, H. P., Yi, D. H., Yu, S. Q., et al. (2006). Administration of Donor-Derived Mesenchymal Stem Cells Can Prolong the Survival of Rat Cardiac Allograft. Transplantation Proceedings, 38, 3046-51. doi:10.1016/j. transproceed.2006. 10. 002.
46. Itakura, S., Asari, S., Rawson, J., et al. (2007). Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. American Journal of Transplantation, 7, 336-46. doi:10.1111/j. 1600-6143.2006. 01643. x.
47. Solari, M. G., Srinivasan, S., Boumaza, I., et al. (2009). Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia. Journal of Autoimmunity, 32, 116-24. doi:10.1016/j. jaut.2009. 01. 003.
48. Wan, C. D., Cheng, R., Wang, H. B., & Liu, T. (2008). Immunomodulatory effects of mesenchymal stem cells derived from adipose tissues in a rat orthotopic liver transplantation model. Hepatobiliary & Pancreatic Diseases International, 7, 29-33.
49. Hong, Z. F., Huang, X. I., Yin, Z. Y., Zhao, W. X., & Wang, X. M. (2009). Immunosuppressive function of bone marrow mesenchymal stem cells on acute rejection of liver allografts in rats. Transplantation Proceedings, 41, 403-9. doi:10.1016/j. transproceed.2008. 10. 020.
50. Zhang, W., Qin, C., & Zhou, Z. M. (2007). Mesenchymal stem cells modulate immune responses combined with cyclosporine in a rat renal transplantation model. Transplantation Proceedings, 39, 3404-8. doi:10.1016/j. transproceed.2007. 06. 092.