Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat

Journal of Applied Toxicology

Volumn 30, Issue 1, 2010, Pages 84-90

  Caride, A ^a   Fernandez Perez B ^a   Cabaleiro, T ^a   Bernardez G ^a   Lafuente, A ^a  

^a UNIVERSITY OF VIGO   (Spain)

Author keywords

Aspartate; Cadmium; Daily pattern; GABA; Glutamate; Glutamine; Mediobasal hypothalamus; Taurine

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; ASPARTIC ACID; CADMIUM CHLORIDE; GLUTAMIC ACID; GLUTAMINE; TAURINE;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DRUG EXPOSURE; ENVIRONMENTAL EXPOSURE; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACIDS; ANIMALS; ASPARTIC ACID; CADMIUM CHLORIDE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; HUMANS; HYPOTHALAMUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TAURINE;

ANIMALIA; RATTUS;

EID: 74549206118     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1472     Document Type: Article

References (84)

1. Abbud R, Smith MS. 1991. Differences in the luteinizing hormone and prolactin responses to multiple injections of kainate, as compared to N-methyl-D,L-aspartate, in cycling rats. Endocrinology 129: 3254-3258.
2. Aguilar E, Tena-Sempere M, Gonzalez D, Pinilla L. 1996. Control of gonadotropin secretion in prepubertal male rats by excitatory amino acids. Andrologia 28: 163-169.
3. Arias P, Goroll D, Convertini V, Jarry H, Wuttke W. 1994. Effects of taurine on basal and stimulated luteinizing hormone (LH) and LH-releasing hormone secretion in ovariectomized rats: in vitro studies. Brain Res. 634: 325-327; doi: 10.1016/0006-8993(94)91937-2.
4. Arias P, Feleder C, Rodríguez M, Ginzburg M, Refojo D, Szwarcfarb B, Moguilevsky JA. 1995. Repeated intracerebroventricular administration of taurine lowers LH levels and postpones vaginal opening in peripubertal female rats. Brain Res. Dev. Brain Res. 85: 137-139; doi: 10.1016/0165-3806(94)00188-6.
5. Arslan M, Pohl CR, Smith MS, Plant TM. 1992. Studies of the role of the N-methyl-d-aspartate (NMDA) receptor in the hypothalamic control of prolactin secretion. Life Sci. 50: 295-300.
6. Bar-Sela S, Reingold S, Richter ED. 2001. Amyotrophic lateral sclerosis in a battery-factory worker exposed to cadmium. Int. J. Occup. Environ. Health 7: 109-112.
7. Bjurstöm H, Wang J, Ericsson I, Bengtsson M, Liu Y, Kumar-Mendu S, Issazadeh-Navikas S, Birnir B. 2008. GABA, a natural immunomodulator of T lymphocytes. J. Neuroimmunol. 205: 44-50; doi: 10.1016/j.jneuroim.2008.08.017
8. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
9. Brann DW, Mahesh VB. 1992. Excitatory amino acid neurotransmission. Endogenous excitatory amino acids. Trends Endocrinol. Metab. 3: 122-126; doi: 10.1006/frne.1994.1002.
10. Cal JC, Desmoulière A, Cambar J. 1984. Comparative study of circadian changes in the mortality induced by mercuric chloride and cadmium sulphate in mice. Ann. Pharm. Fr. 42: 487-494.
11. Cambar J, Cal JC, Desmouliere A, Guillemain J. 1983. Circadian variations of the mortality of mice due to cadmium sulphate. C. R. Seances Acad. Sci. III 296: 949-952.
12. Cano P, Poliandri AH, Jiménez V, Cardinali DP, Esquifino AI. 2007. Cadmium induced changes in Per 1 and Per 2 gene expression in rat hypothalamus and anterior pituitary: effect of melatonin. Toxicol. Lett. 172: 131-136; doi: 10.1016/j.toxlet.2007.05.011.
13. Canteras NS. 2002. The medial hypothalamic defensive system: hodological organization and functional implications. Pharmacol. Biochem. Behav. 71: 481-91. Review; doi: 10.1016/S0091-3057(01)00685-2
14. 2+-ATPase activities: protection by L-cysteine. Basic Clin. Pharmacol. Toxicol. 94: 112-118; doi: 10.1111/j.1742-7843.2004.pto940303.x.
15. Caride A, Fernández-Pérez B, Cabaleiro T, Esquifino AI, Lafuente A. 2009. Cadmium exposure disrupts GABA and taurine regulation of prolactin secretion in adult male rats. Toxicol. Lett. 185: 175-179; doi: 10.1016/j.toxlet.2008.12.016
16. Casanueva F, Apud JA, Masotto C, Cocchi D, Locatelli V, Racagni G, Muller E. 1984. Daily fluctuations in the activity of the tuberoinfundibular GABAergic system and plasma prolactin levels. Neuroendocrinology 39: 367-370.
17. Coogan AN, Wyse CA. 2008. Neuroimmunology of the circadian clock. Brain Research 1232: 104-112; doi: 10.1016/j.brainres.2008.07.087
18. Cory-Slechta DA, Weiss B. 1981. Aversiveness of cadmium in solution. Trends Neurosci. 19: 417-422.
19. Cuadrado C, Kumpulainen J, Moreiras O. 1995. Lead, cadmium and mercury contents in average Spanish market basket diets from Galicia, Valencia, Andalucía and Madrid. Food Addit. Contam. 12: 107-118.
20. Czyrak A, Czepiel K, Ma?kowiak M, Chocyk A, Wedzony K. 2003. Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Brain Res. 989: 42-51; doi: 10.1016/S0006-8993(03)03352-3.
21. Das KP, Das PC, Dasgupta S, Dey CD. 1993. Serotonergic-cholinergic neurotransmitters' function in brain during cadmium exposure in protein restricted rat. Biol. Trace Elem. Res. 36: 119-127; doi: 10.1007/BF02783170.
22. Devoino L, Idova G, Beletskaya I. 1992. Participation of a GABA-ergic system in the processes of neuroimmunomodulation. Int. J. Neurosci. 67: 215-27.
23. Dhandapani KM, Brann DW. 2000. The role of glutamate and nitric oxide in the reproductive neuroendocrine system. Biochem. Cell Biol. 78: 165-179.
24. Duvilanski BH, Selgas L, García-Bonacho M, Esquifino AI. 1998. Daily variations of amino acid concentration in mediobasal hypothalamus, in rats injected with Freund's adjuvant. Effect of cyclosporine. J. Neuroimmunol. 87: 189-196; doi: 10.1016/S0165-5728(98)00108-8
25. Duvilanski BH, Alvarez MP, Castrillón PO, Cano P, Esquifino AI. 2003. Daily changes of GABA and taurine concentrations in various hypothalamic areas are affected by chronic hyperprolactinemia. Chronobiol. Int. 20: 271-284; doi: 10.1081/CBI-120018577.
26. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. 2000. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 52: 595-638; doi: 0031-6997/00/5204- 0595$03.00/0.
27. Esquifino AI, García-Bonacho M, Castrillón PO, Duvilanski BH. 2000. Effect of chronic hyperprolactinemia on daily changes of glutamate and aspartate concentrations in the median eminence and different hypothalamic areas of male rats. Chronobiol. Int. 17: 631-643.
28. Esquifino AI, Seara R, Fernández-Rey E, Lafuente A. 2001. Alternate cadmium exposure differentially affects the content of gamma-aminobutyric acid (GABA) and taurine within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats. Arch. Toxicol. 75: 127-133; doi: 10.1007/s002040100224.
29. Feleder C, Jarry H, Leonhardt S, Moguilevsky JA, Wuttke W. 1996. Evidence to suggest that gonadotropin-releasing hormone inhibits its own secretion by affecting hypothalamic amino acid neurotransmitter release. Neuroendocrinology 64: 298-304.
30. Fernández-Pérez B. 2008. Efectos tóxicos del cadmio en la regulación aminoacidérgica de la secreción hipofisaria. Doctoral thesis, University of Vigo.
31. Freeman ME, Kanyicska B, Lerant A, Nagy G. 2000. Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80: 1523-1631.
32. Fox MR. 1983. Cadmium bioavailability. Fed. Proc. 42: 1726-179.
33. Hinkle PM, Kinsella PA, Osterhoudt KC. 1987. Cadmium uptake and toxicity via voltage-sensitive calcium channels. J. Biol. Chem. 262: 16333-16337.
34. Holloway WR Jr, Thor DH. 1988. Social memory deficits in adult male rats exposed to cadmium in infancy. Neurotoxicol. Teratol. 10: 193-197.
35. IARC. 1993. Monographs on the Evaluation of the Carcinogenic Risks to Humans, Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry. IARC Scientific Publications. International Agency for Research on Cancer: Lyon; 119-238.
36. Ikeda M. 2004. Calcium dynamics and circadian rhythms in suprachi asmatic nucleus neurons. Neuroscientist 10: 315-24; doi: 10.1177/10738584031262149
37. Jihen el H, Imed M, Fatima H, Abdelhamid K. 2008. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem. Toxicol. 46: 3522-3527; doi: 10.1016/j.fct.2008.08.037.
38. Karabulut-Bulan O, Bolkent S, Yanardag R, Bilgin-Sokmen B. 2008. The role of vitamin C, vitamin E, and selenium on cadmium-induced renal toxicity of rats. Drug Chem. Toxicol. 31: 413-426; doi: 10.1080/ 01480540802383200.
39. Krieger MS, Conrad LC, Pfaff DW. 1979. An autoradiographic study of the efferent connections of the ventromedial nucleus of the hypothalamus. J. Comp. Neurol. 183: 785-815.
40. Lafuente A, Esquifino AI. 1999. Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male. Toxicol Lett. 110: 209-218; doi: 10.1016/S0378-4274(99)00159-9.
41. Lafuente A, Esquifino AI. 2002. Possible role of glutamate, aspartate, glutamine, GABA or taurine on cadmium toxicity on the hypothalamic pituitary axis activity in adult male rats. Biometals 15: 183-187; doi: 10.1023/A:1015255406461.
42. Lafuente A, Fenández-Rey E, Seara R, Pérez-Lorenzo M, Esquifino AI. 2001a. Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats. Neurochem. Int. 39: 187-192; doi: 10.1016/S0197-0186(01)00029-8.
43. Lafuente A, Márquez N, Pérez-Lorenzo M, Pazo D, Esquifino AI. 2001b. Cadmium effects on hypothalamic-pituitary-testicular axis in male rats. Exp. Biol. Med. (Maywood) 226: 605-611; doi: 0037-9727/01/2266-0605$15.00.
44. Lafuente A, González-Carracedo A, Romero A, Esquifino AI. 2003a. Effect of cadmium on 24-h variations in hypothalamic dopamine and serotonin metabolism in adult male rats. Exp. Brain Res. 149: 200-206; doi: 10.1007/s00221-002-1356-6.
45. Lafuente A, Cano P, Esquifino AI. 2003b. Are cadmium effects on plasma gonadotropins, prolactin, ACTH, GH and TSH levels, dose-dependent? Biometals 16: 243-250; doi: 10.1023/A:1020658128413.
46. Lafuente A, González-Carracedo A, Romero A, Cano P, Esquifino AI. 2004a. Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels. Toxicol. Lett. 146: 175-182; doi: 10.1016/j.toxlet.2003. 10.004.
47. Lafuente A, González-Carracedol A, Esquifino AI. 2004b. Differential effects of cadmium on blood lymphocyte subsets. Biometals 17: 451-6; doi: 10.1023/B:BIOM.0000029441.20037.72
48. Lafuente A, González-Carracedo A, Romero A, Cabaleiro T, Esquifino AI. 2005a. Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats. Toxicol. Lett. 155: 87-96; doi: 10.1016/j.toxlet.2004.08.011.
49. Lafuente A, González-Carracedo A, Cabaleiro T, Romero A, Esquifino AI. 2005b. Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats. J. Physiol. Biochem. 61: 439-446.
50. Lafuente A, Cabaleiro T, Caride A, Gutiérrez A, Esquifino AI. 2007. Toxic effects of methoxychlor in rat striatum: modifications in several neurotransmitters. J. Physiol. Biochem. 63: 171-177.
51. Manna P, Sinha M, Sil PC. 2008. Cadmium induced testicular pathophysiology: prophylactic role of taurine. Reprod. Toxicol. 26: 282-291; doi: 10.1016/j.reprotox.2008.09.009.
52. 2+ mobilization in hepatocytes. Biochem. J. 339: 555-561.
53. Méndez JA, Bourque MJ, Dal Bo G, Bourdeau ML, Danik M, Williams S, Lacaille JC, Trudeau LE. 2008. Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons. J Neurosci. 28: 6309-6318; doi: 0270-6474/08/286309 -10$15.00/0.
54. Minami A, Takeda A., Nishibaba D, Takefuta S, Oku N. 2001. Cadmium toxicity in synaptic neurotransmission in the brain. Brain Res. 894: 336-339; doi: 10.1016/S0006-8993(01)02022-4.
55. Murphy VA. 1997. Cadmium: acute and chronic neurological disorders. In Mineral and Metal: Neurotoxicology, Yasui M, Strong MJ, Ota K (eds). CRC Press, Boca Raton, FL; 229-240.
56. Nahm SS, Farnell YZ, Griffith W, Earnest DJ. 2005. Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus. J. Neurosci. 25: 9304-9308; doi: 10.1523/JNEUROSCI.2733- 05.2005
57. Nampoothiri LP, Gupta S. 2006. Simultaneous effect of lead and cadmium on granulosa cells: a cellular model for ovarian toxicity. Reprod. Toxicol. 21: 179-185; doi: 10.1016/j.reprotox.2005.07.010.
58. Okamura H. 2007. Suprachiasmatic nucleus clock time in the mammalian circadian system. Cold Spring Harb. Symp. Quant. Biol. 72: 551-556.
59. Okuda B, Iwamoto Y, Tachibana H, Sugita M. 1997. Parkinsonism after acute cadmium poisoning. Clin. Neurol. Neurosurg. 99: 263-265.
60. Pampillo M, Scimonelli T, Bottino MC, Duvilanski BH, Rettori V, Seilicovich A, Lasaga M. 2002. The effect of d-aspartate on luteinizing hormonereleasing hormone, alpha-melanocyte-stimulating hormone, GABA and dopamine release. Neuroreport 13: 2341-2344.
61. Pillai A, Priya L, Gupta S. 2003. Effects of combined exposure to lead and cadmium on the hypothalamic-pituitary axis function in proestrous rats. Food Chem. Toxicol. 41: 379-384; doi: 10.1016/S0278-6915(02)00247- 8.
62. Ping L, Mahesh VB, Brann DW. 1995. Effect of NMDA and non-NMDA receptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat. Neuroendocrinology 61: 226-234.
63. Real Ordinance 1201/2005. 10 October 2005. Sobre protección de los animales utilizados para experimentación y otros fines científicos. BOE 252, 21 October 2005; 34367-34391.
64. Repetto M, López-Artíguez M. 1995. Estado actual de la Toxicología del cadmio. In Toxicología Avanzada, de Santos D (ed.). Madrid; 393-418.
65. Rose CS, Heywood PG, Costanzo RM. 1992. Olfactory impairment after chronic occupational cadmium exposure. J. Occup. Med. 34: 600-605.
66. Shimada H, Funakoshi T, Waalkes MP. 2000. Acute, nontoxic cadmium exposure inhibits pancreatic protease activities in the mouse. Toxicol. Sci. 53: 474-480.
67. Shukla A, Shukla GS, Srimal RC. 1996. Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat. Hum. Exp. Toxicol. 15: 400-405.
68. Stapleton PP, Mahon TM, Nowlan P, Bloomfield FJ. 1994. Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats. J. Pharm. Pharmacol. 46: 745-750.
69. Sumová A, Jác M, Sládek M, Sauman I, Illnerová H. 2003. Clock gene daily profiles and their phase relationship in the rat suprachiasmatic nucleus are affected by photoperiod. J Biol. Rhythms 18: 134-144; doi: 10.1177/0748730403251801.
70. 109Cd transport in rat brain. Brain Res. Bull. 49: 453-457; doi: 10.1016/S0361-9230 (99)00080-5.
71. Tal J, Price MT, Olney JW. 1983. Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in rodents or primates. Brain Res. 273: 179-182.
72. The Commission of the European Communities. 1986. Council Directive (1986/609/EC) of 24 November 1986 on the approximation of laws, regulation and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. DOCE L 358, 18 December 1986; 1-28.
73. The Commission of the European Communities. 2001. European Community Regulation (2001/466/EC) of 8 March 2001 setting maximum levels for certain contaminants in foodstuffs. DOCE L 77, 16 March 2001; 1-27.
74. Tournier BB, Dardente H, Simonneaux V, Vivien-Roels B, Pévet P, Masson-Pévet M, Vuillez P. 2007. Seasonal variations of clock gene expression in the suprachiasmatic nuclei and pars tuberalis of the European hamster (Cricetus cricetus). Eur. J. Neurosci. 25: 1529-1536; doi: 10.1111/j.1460-9568.2007.05421.x
75. van den Pol AN, Wuarin JP, Dudek FE. 1990. Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science. 250: 1276-1278.
76. Viaene MK, Masschelein R, Leenders J, De Groof M, Swerts LJ, Roels HA. 2000. Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study. Occup. Environ. Med. 57: 19-27; doi: 10.1136/oem.57.1.19.
77. 2+)-ATPase activity. Biochim. Biophys. Acta 1152: 26-34.
78. Wagner EJ, Goudreau JL, Moore KE, Lookingland KJ. 1994. GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat. Brain Res. 659: 194-200; doi: 10.1016/0006-8993(94)90878-8.
79. Wang S, Hu P, Wang HL, Wang M, Chen JT, Tang JL, Ruan DY. 2008. Effects of Cd(2+) on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area. Toxicol. Lett. 176: 215-222; doi: 10.1016/j.toxlet.2007.11. 008.
80. Wang YY, Legendre P, Huang J, Wang W, Wu SX, Li YQ. 2008. The effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons. J. Chem. Neuroanat. 36: 150-159; doi: 10.1016/j.jchemneu.2008.07.001.
81. Wollnik F. 1991. Strain differences in the pattern and intensity of wheel running activity in laboratory rats. Experientia 47: 593-598.
82. Wong KL, Klaassen CD. 1982. Neurotoxic effects of cadmium in young rats. Toxicol. Appl. Pharmacol. 63: 330-337.
83. Wong PC, Lai JC, Lim L, Davison AN. 1981. Selective inhibition of Lglutamate and gammaaminobutyrate transport in nerve ending particles by aluminium, manganese, and cadmium chloride. J. Inorg. Biochem. 14: 253-260.
84. World Health Organization. 2000. Evaluation of certain food additives and contaminants. In 55th Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO: Geneva.