Antifibrotic effects of ZK14, a novel nitric oxide-donating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCl 4-induced hepatic fibrosis

Acta Pharmacologica Sinica

Volumn 31, Issue 1, 2010, Pages 27-34

  Dai, Li ^a   Ji, Hui ^a   Kong, Xiang Wen ^a   Zhang, Yi Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Biphenyldicarboxylate; CCl4; Hepatic fibrosis; HSC T6; Nitric oxide; ZK14

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIFIBROTIC AGENT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CASPASE; CASPASE 3; CASPASE 9; COLLAGEN TYPE 3; HYALURONIC ACID; NITRIC OXIDE; UNCLASSIFIED DRUG; ZK 14; 4,4' DIMETHOXY 5,6,5',6' DIMETHYLENEDIOXY 2 METHOXYCARBONYL 2' (N (ALANINE 2 (3 PHENYLSULFONYL 1,2,5 OXADIAZOLE 2 OXIDE 4 ) OXYETHOXYETHYL ESTER)) CARBAMOYL BIPHENYL; 4,4'-DIMETHOXY-5,6,5',6'-DIMETHYLENEDIOXY-2-METHOXYCARBONYL-2'-(N-(ALANINE 2-(3-PHENYLSULFONYL-1,2,5-OXADIAZOLE-2-OXIDE-4-) OXYETHOXYETHYL ESTER)) CARBAMOYL BIPHENYL; BIPHENYL DERIVATIVE; NITRIC OXIDE DONOR; OXADIAZOLE DERIVATIVE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; FIBROGENESIS; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LOW DRUG DOSE; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NICK END LABELING; NONHUMAN; RAT; STELLATE CELL; ANIMAL; CELL LINE; DOSE RESPONSE; EXPERIMENTAL LIVER CIRRHOSIS; LIVER FUNCTION TEST; METABOLISM; PATHOPHYSIOLOGY; RANDOMIZATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; APOPTOSIS; BIPHENYL COMPOUNDS; CARBON TETRACHLORIDE; CASPASE 3; CASPASE 9; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATIC STELLATE CELLS; IN SITU NICK-END LABELING; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER FUNCTION TESTS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE DONORS; OXADIAZOLES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 74549203244     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.170     Document Type: Article

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