Design principles for ligand-sensing, conformation-switching ribozymes

PLoS Computational Biology

Volumn 5, Issue 12, 2009, Pages

  Chen, Xi ^a   Ellington, Andrew D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; ECONOMIC AND SOCIAL EFFECTS; MEDICAL APPLICATIONS; NUCLEIC ACIDS; THERMODYNAMICS;

DESIGN PRINCIPLES; IN-VITRO; IN-VIVO; NUCLEIC ACID SENSORS; PERFORMANCE; RATIONAL DESIGN; RIBOSWITCHES; RIBOZYMES; SENSOR ELEMENTS; THEORETICAL FRAMEWORK;

LIGANDS;

APTAMER; APTAZYME; MESSENGER RNA; RIBOZYME; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; BIOSENSOR; CATALYSIS; CONCEPTUAL FRAMEWORK; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME CONFORMATION; GENE EXPRESSION; LIGAND BINDING; MOLECULAR RECOGNITION; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; RIBOSWITCH; THERMODYNAMICS; ALGORITHM; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; ULTRASTRUCTURE;

ALGORITHMS; APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BINDING SITES; COMPUTER SIMULATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RNA, CATALYTIC;

EID: 74549198217     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000620     Document Type: Article

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