Effect of a blind spot in a dielectrophoretic field on the separation of human breast cancer cells (MCF 7)

Journal of Mechanical Science and Technology

Volumn 23, Issue 11, 2009, Pages 3132-3139

  Kim, Youngho ^a   Lee, Jangwon ^a   An, Jaemin ^a   Lee, Sang Ho ^b   Kim, Byungkyu ^a  

^a Hankuk Aviation University   (South Korea)

^b Korea University   (South Korea)

Author keywords

Cell separation; DACS; Dielectrophoresis; MCF 7

Indexed keywords

BLIND SOURCE SEPARATION; DIELECTRIC DEVICES; DIELECTRIC MATERIALS; DISEASES; EFFICIENCY; ELECTROPHORESIS; ERRORS; CYTOLOGY; SIZE SEPARATION;

CELL SEPARATION; DACS; DIELECTROPHORETIC; FLUORESCENT MATERIALS; HUMAN BREAST CANCER CELLS; MCF 7; SEPARATION EFFICIENCY; SPECIFIC FREQUENCIES; BLIND SPOTS; CELL MIXTURES; CELL SIZE; CELL SORTING; CFD-ACE+; COMMERCIAL CODES; DIELECTROPHORESIS; IN-CELL; TARGET CELLS; WEAK FORCE;

SEPARATION; CELLS;

EID: 74549196934     PISSN: 1738494X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12206-009-0910-6     Document Type: Article

References (20)

1. M. Toner and D. Irimia, Blood-on-a-chip, Annu. Rev. Biomed. Eng. 7 (2005) 77-103.
2. P. R. C. Gascoyne and J. Vykoukal, Particle separation by dielectrophoresis, Electrophoresis 23 (2002) 1973-1983.
3. Y. Li, C. Dalton, H. J. Crabtree, G. Nilsson and K. V. I. S. Kaler, Continuous dielectrophoretic cell separation microfluidic device, Lab Chip 7 (2007) 239-248.
4. A. Rosenthal, B. M. Taff and J. Voldman, Quantitative modeling of dielectrophoretic traps, Lap Chip 6 (2006) 508-515.
5. M. A. M. Gijs, Magnetic bead handling on-chip: new opportunities for analytical applications Microfluid Nanofluid 1 (2004) 22-40.
6. K. Han and A. B. Frazier, Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations, Lap Chip 6 (2006) 265-273.
7. Y. Kim, S. Hong, S. H. Lee, K. Lee, S. Yun, Y. Kang, K. Paek, B. Ju and B. Kim, Novel platform for minimizing cell loss on separation process: Droplet-based magnetically activated cell separator, Rev. Sci. Instrum. 78 (2007) 074301-074307.
8. D. G. Grier, A revolution in optical manipulation, Nature 424 (2003) 21-27.
9. S. Choi and J. Park, Continuous hydrophoretic separation and sizing of microparticles using slanted obstacles in a microchannel, Lap Chip 7 (2007) 890-897.
10. M. Yamada and M. Seki, Microfluidic Particle Sorter Employing Flow Splitting and Recombining, Anal. Chem. 78 (2006) 1357-1362.
11. A. Neild, S. Oberti, G. Radziwill and J. Dual, Simultaneous positioning of cells into two-dimensional arrays using ultrasound, Biotechnol. Bioeng. 97 (2007) 1335-1339.
12. M. Wiklund, C. G̈nther, R. Lemor, M. Jäger, G. Fuhr and H. M. Herts, Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip, Lab Chip 6 (2006) 1537-1544.
13. K. Kwon, S. Choi, S. Lee, B. Kim, S. Lee, M. Park, P. Kim, S. Hwang and K. Suh, Label-free, microfluidic separation and enrichment of human breast cancer cells by adhesion difference, Lab Chip 7 (2007) 1461-1468.
14. R. Gambari, M. Borgatti, L. Altomare, N. Manaresi, G. Medoro, A. Romani, M. Tartagni and R. Guerrieri, Applications to cancer research of "Lab-on-a-chip" devices based on dielectrophoresis (DEP), Technol. Cancer Res. T. 2 (2003) 31-39.
15. J. Park, B. Kim, S. K. Choi, S. Hong, S. H. Lee and K. Lee, An efficient cell separation system using 3D-asymmetric microelectrodes, Lab Chip 5 (2005) 1264-1270.
16. J. An, Y. Kim, B. Kim, S. Park, J. Park, J. Lee and S. Lee, Proc IEEE Conf Sens 2006, Daegu, Korea, (2007) 162-165.
17. M. P. Hughes, Nanoelectromechanics in Engineering and Biology, CRC Press, Boca Raton, FL, USA, (42) 2003.
18. H. A. Pohl, Dielectrophoresis, Cambridge University Press, Cambridge, UK, 34 (1978).
19. M. dürr, J. Kentsch, T. Müller, T. Schnelle and M. Stelzle, Microdevices for manipulation and accumulation of micro- and nanoparticles by dielectrophoresis, Electrophoresis 24 (2003) 722-731.
20. P. R. C. Gascoyne, X. B. Wang, Y. Huang and F. Becker, Dielectrophoretic separation of cancer cells from blood, IEEE Trans. Ind. Appl. 33 (1997) 670-678.