Acute cardiac allograft rejection by directly cytotoxic CD4 T cells: Parallel requirements for fas and perforin

Transplantation

Volumn 89, Issue 1, 2010, Pages 33-39

  Grazia, Todd J ^a,b,c   Plenter, Robert J ^a,b,d   Weber, Sarah M ^a,b   Lepper, Helen M ^a,b   Victorino, Francisco ^a,b   Zamora, Martin R ^a,b   Pietra, Biagio A ^b,d   Gill, Ronald G ^b,c,e  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^d CHILDREN S HOSPITAL COLORADO   (United States)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acute rejection.; Cytotoxic CD4 T cells; Cytotoxicity; Transplantation

Indexed keywords

FAS ANTIGEN; FAS LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GRAFT RECIPIENT; HEART TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VASCULAR DISEASE; WILD TYPE;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; GRAFT REJECTION; H-2 ANTIGENS; HEART TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; T-LYMPHOCYTES, CYTOTOXIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 74549187443     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181be6bc7     Document Type: Article

References (39)

1. Valantine H. Cardiac allograft vasculopathy after heart transplantation: Risk factors and management. J Heart Lung Transplant 2004; 23 (5 suppl): S187.
2. Bennett LE, Keck BM, Hertz MI, et al. Worldwide thoracic organ transplantation: A report from the UNOS/ISHLT international registry for thoracic organ transplantation. Clin Transpl 2001: 25.
3. Hunt S, Billingham M. Long-term results of cardiac transplantation. AnnuRevMed 1991; 42: 437.
4. Yin D, Fathman CG. CD4-positive suppressor cells block allotrans-plant rejection. J Immunol 1995; 154: 6339.
5. Herbert J, Roser B. Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplantation 1988; 46 (2 suppl): 128S.
6. Shizuru JA, Seydel KB, Flavin TF, et al. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation 1990; 50: 366.
7. Pietra BA, Wiseman A, Bolwerk A, et al. CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class II. J Clin Invest 2000; 106: 1003.
8. Grazia TJ, Pietra BA, Johnson ZA, et al. A two-step model of acute CD4 T cell mediated cardiac allograft rejection. J Immunol 2004; 172: 7451.
9. Kagi D, Ledermann B, Burki K, et al. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996; 14: 207.
10. Siegel RM, Chan FK, Chun HJ, et al. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 2000; 1: 469.
11. Hanabuchi S, Koyanagi M, Kawasaki A, et al. Fas and its ligand in a general mechanism of T cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1994; 91: 4930.
12. Kagi D, Vignaux F, Ledermann B, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994; 265: 528.
13. Ju ST, Cui H, Panka DJ, et al. Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 andCD8+ cytotoxic T cells. Proc Natl Acad Sci USA 1994; 91: 4185.
14. Stalder T, Hahn S, Erb P. Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J Immunol 1994; 152: 1127.
15. Seino K, Kayagaki N, Bashuda H, et al. Contribution of Fas ligand to cardiac allograft rejection. Int Immunol 1996; 8: 1347.
16. Larsen CP, Alexander DZ, Hendrix R, et al. Fas-mediated cytotoxicity. An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses? Transplantation 1995; 60: 221.
17. Strehlau J, Pavlakis M, Lipman M, et al. Quantitative detection of immune activation transcripts as a diagnostic toll in kidney transplantation. Proc Natl Acad Sci USA 1997; 97: 695.
18. Li B, Hartono C, Ding R, et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and gran-zyme B in urine. N Engl J Med 2001; 344: 947.
19. Simon T, Opelz G, Wiesel M, et al. Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients. Am J Transplant 2003; 3: 1121.
20. Hombach A, Heuser C, Marquardt T, et al. CD4+ T cells engrafted with a recombinant immunoreceptor efficiently lyse target cells in a MHC antigen-and Fas-independent fashion. J Immunol 2001; 167:1090.
21. Adhikary D, Behrends U, Moosmann A, et al. Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins. J Exp Med 2006; 203: 995.
22. Jellison ER, Kim SK, Welsh RM. Cutting edge: MHC class II-restricted killing in vivo during viral infection. J Immunol 2005; 174: 614.
23. Watanabe-Fukunaga R, Brannan CI, Copeland NG, et al. Lymphopro-liferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314.
24. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343.
25. Sarmiento M, Glasebrook AL, Fitch FW. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 1980; 125: 2665.
26. Glimcher LH, Kim KJ, Green I, et al. Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med 1982; 155: 445.
27. Sleater M, Diamond AS, Gill RG. Islet allograft rejection by contact-dependent CD8+ T cells: Perforin and FasL play alternate but obligatory roles. Am J Transplant 2007; 7: 1927.
28. Pietra B, Rizeq M, Bolwerk A, et al. CD4 T cells acutely reject cardiac allografts via direct donor recognition. Transplant Proc 1999; 31: 92.
29. Buller RM, Holmes KL, Hugin A, et al. Induction of cytotoxic T cell responses in vivo in the absence of CD4 helper cells. Nature 1987; 328: 77.
30. Bishop DK, Chan S, Li W, et al. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 1993; 56: 892.
31. Nickerson P, Steiger J, Zheng XX, et al. Manipulation of cytokine networks in transplantation: False hope or realistic opportunity for tolerance? Transplantation 1997; 63: 489.
32. Schulz M, Schuurman HJ, Joergensen J, et al. Acute rejection of vascular heart allografts by perforin-deficient mice. Eur J Immunol 1995; 25: 474.
33. Suzuki I, Fink PJ. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J Exp Med 1998; 187:123.
34. Suzuki I, Fink PJ. The dual functions of Fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc Natl Acad Sci USA 2000; 97: 1707.
35. Kennedy NJ, Kataoka T, Tschopp J, et al. Caspase activation is required for T cell proliferation. J Exp Med 1999; 190: 1891.
36. Alam A, Cohen LY, Aouad S, et al. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in non-apoptotic cells. J Exp Med 1999; 190: 1879.
37. Zhang J, Cado D, Chen A, et al. Fas-mediated apoptosis and activation-induced T cell proliferation are defective in mice lacking FADD/Mort1. Nature 1998; 392: 296.
38. Yamada A, Laufer TM, Gerth AJ, et al. Further analysis of the T cell subsets and pathways of murine cardiac allograft rejection. Am JTransplant 2003; 3: 23.
39. Szeto WY, Krasinskas AM, Kreisel D, et al. Depletion of recipient CD4+ but not CD8+ T lymphocytes prevents the development of cardiac allograft vasculopathy. Transplantation 2002; 73: 1116.