Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp. paratuberculosis

Clinical and Vaccine Immunology

Volumn 17, Issue 1, 2010, Pages 108-117

  Gillan, Sonia ^a   O'Brien, Rory ^a   Hughes, Alan D ^a   Griffin, J Frank T ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; ATYPICAL MYCOBACTERIOSIS; B LYMPHOCYTE; BLOOD SAMPLING; CD25+ T LYMPHOCYTE; CELL POPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; EX VIVO STUDY; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSTIMULATION; MYCOBACTERIUM AVIUM; NONHUMAN; PARATUBERCULOSIS; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BACTERIAL; B-LYMPHOCYTES; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; SEVERITY OF ILLNESS INDEX; SHEEP DISEASES; T-LYMPHOCYTES;

EID: 74549179207     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00359-09     Document Type: Article

References (28)

1. Begg, D. J., R. O'Brien, C. G. Mackintosh, and J. F. Griffin. 2005. Experimental infection model for Johne's disease in sheep. Infect. Immun. 73: 5603-5611.
2. Burrells, C., C. J. Clarke, A. Colston, J. M. Kay, J. Porter, D. Little, and J. M. Sharp. 1999. Interferon-gamma and interleukin-2 release by lymphocytes derived from the blood, mesenteric lymph nodes and intestines of normal sheep and those affected with paratuberculosis (Johne's disease). Vet. Immunol. Immunopathol. 68:139-148.
3. Burrells, C., C. J. Clarke, A. Colston, J. M. Kay, J. Porter, D. Little, and J. M. Sharp. 1998. A study of immunological responses of sheep clinically-affected with paratuberculosis (Johne's disease). The relationship of blood, mesenteric lymph node and intestinal lymphocyte responses to gross and microscopic pathology. Vet. Immunol. Immunopathol. 66:343-358.
4. Bustin, S. A. 2004. A-Z of quantitative PCR, vol. 5. International University Line Press, La Jolla, CA.
5. Carrigan, M. J., and J. T. Seaman. 1990. The pathology of Johne's disease in sheep. Aust. Vet. J. 67:47-50.
6. Chiodini, R. J. 1996. Immunology: resistance to paratuberculosis. Vet. Clin. North Am. Food Anim. Pract. 12:313-343.
7. Clarke, C. J., and D. Little. 1996. The pathology of ovine paratuberculosis: gross and histological changes in the intestine and other tissues. J. Comp. Pathol. 114:419-437.
8. Corpa, J. M., J. Garrido, J. F. Garcia Marin, and V. Perez. 2000. Classification of lesions observed in natural cases of paratuberculosis in goats. J. Comp. Pathol. 122:255-265.
9. Coussens, P. M., A. Jeffers, and C. Colvin. 2004. Rapid and transient activation of gene expression in peripheral blood mononuclear cells from Johne's disease positive cows exposed to Mycobacterium paratuberculosis in vitro. Microb. Pathog. 36:93-108.
10. Coussens, P. M., C. B. Pudrith, K. Skovgaard, X. Ren, S. P. Suchyta, J. R. Stabel, and P. M. Heegaard. 2005. Johne's disease in cattle is associated with enhanced expression of genes encoding IL-5, GATA-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells. Vet. Immunol. Immunopathol. 105:221-234.
11. Coussens, P. M., N. Verman, M. A. Coussens, M. D. Elftman, and A. M. McNulty. 2004. Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern. Infect. Immun. 72:1409-1422.
12. de Almeida, D. E., C. J. Colvin, and P. M. Coussens. 2008. Antigen-specific regulatory T cells in bovine paratuberculosis. Vet. Immunol. Immunopathol. 125:234-245.
13. Griffin, J. F., J. P. Cross, D. N. Chinn, C. R. Rodgers, and G. S. Buchan. 1994. Diagnosis of tuberculosis due to Mycobacterium bovis in New Zealand red deer (Cervus elaphus) using a composite blood test and antibody assays. N. Z. Vet. J. 42:173-179.
14. Griffin, J. F., E. Spittle, C. R. Rodgers, S. Liggett, M. Cooper, D. Bakker, and J. P. Bannantine. 2005. Immunoglobulin G1 enzyme-linked immunosorbent assay for diagnosis of Johne's disease in red deer (Cervus elaphus). Clin. Diagn. Lab. Immunol. 12:1401-1409.
15. Griffin, J. F., A. D. Hughes, S. Liggett, P. A. Farquhar, C. G. Mackintosh, and D. Bakker. 2009. Efficacy of novel lipid-formulated whole bacterial cell vaccines against Mycobacterium avium subsp. paratuberculosis in sheep. Vaccine 27:911-918.
16. Hines, S. A., C. D. Buergelt, J. H. Wilson, and E. L. Bliss. 1987. Disseminated Mycobacterium paratuberculosis infection in a cow. J. Am. Vet. Med. Assoc. 190:681-683.
17. Koets, A., V. Rutten, A. Hoek, F. van Mil, K. Muller, D. Bakker, E. Gruys, and W. van Eden. 2002. Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect. Immun. 70:3856-3864.
18. Little, D., H. M. Alzuherri, and C. J. Clarke. 1996. Phenotypic characterisation of intestinal lymphocytes in ovine paratuberculosis by immunohistochemistry. Vet. Immunol. Immunopathol. 55:175-187.
19. Mackintosh, C. G., R. E. Labes, R. G. Clark, G. W. de Lisle, and J. F. Griffin. 2007. Experimental infections in young red deer (Cervus elaphus) with a bovine and an ovine strain of Mycobacterium avium subsp. paratuberculosis. N. Z. Vet. J. 55:23-29.
20. Morris, C. A., S. M. Hickey, and H. A. Henderson. 2006. The effect of Johne's disease on production traits in Romney, Merino and Merino x Romneycross ewes. N. Z. Vet. J. 54:204-209.
21. Navarro, J. A., G. Ramis, J. Seva, F. J. Pallares, and J. Sanchez. 1998. Changes in lymphocyte subsets in the intestine and mesenteric lymph nodes in caprine paratuberculosis. J. Comp. Pathol. 118:109-121.
22. O'Brien, R., C. G. Mackintosh, D. Bakker, M. Kopecna, I. Pavlik, and J. F. Griffin. 2006. Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus). Infect. Immun. 74:3530-3537.
23. Ramakers, C., J. M. Ruijter, R. H. L. Deprez, and A. F. M. Moorman. 2003. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci. Lett. 339:62-66.
24. Reddacliff, L., J. Eppleston, P. Windsor, R. Whittington, and S. Jones. 2006. Efficacy of a killed vaccine for the control of paratuberculosis in Australian sheep flocks. Vet. Microbiol. 115:77-90.
25. Reddacliff, L. A., S. J. McClure, and R. J. Whittington. 2004. Immunoperoxidase studies of cell mediated immune effector cell populations in early Mycobacterium avium subsp. paratuberculosis infection in sheep. Vet. Immunol. Immunopathol. 97:149-162.
26. Smeed, J. A., C. A. Watkins, S. M. Rhind, and J. Hopkins. 2007. Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis. BMC Vet. Res. 3:18.
27. Storset, A. K., H. J. Hasvold, M. Valheim, H. Brun-Hansen, G. Berntsen, S. K. Whist, B. Djonne, C. M. Press, G. Holstad, and H. J. Larsen. 2001. Subclinical paratuberculosis in goats following experimental infection. An immunological and microbiological study. Vet. Immunol. Immunopathol. 80:271-287.
28. Tanaka, S., M. Sato, T. Onitsuka, H. Kamata, and Y. Yokomizo. 2005. Inflammatory cytokine gene expression in different types of granulomatous lesions during asymptomatic stages of bovine paratuberculosis. Vet. Pathol. 42:579-588.